8WFQ

The Crystal Structure of RALDH1 from Biortus.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001523	biological_process	retinoid metabolic process
A	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0005096	molecular_function	GTPase activator activity
A	0005497	molecular_function	androgen binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006081	biological_process	aldehyde metabolic process
A	0006629	biological_process	lipid metabolic process
A	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
A	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
A	0030392	biological_process	fructosamine catabolic process
A	0030424	cellular_component	axon
A	0036438	biological_process	maintenance of lens transparency
A	0042572	biological_process	retinol metabolic process
A	0045202	cellular_component	synapse
A	0051287	molecular_function	NAD binding
A	0070062	cellular_component	extracellular exosome
A	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
A	0110095	biological_process	cellular detoxification of aldehyde
A	0120163	biological_process	negative regulation of cold-induced thermogenesis
A	0140087	molecular_function	acetaldehyde dehydrogenase (NAD+) activity
B	0000166	molecular_function	nucleotide binding
B	0001523	biological_process	retinoid metabolic process
B	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0005096	molecular_function	GTPase activator activity
B	0005497	molecular_function	androgen binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006081	biological_process	aldehyde metabolic process
B	0006629	biological_process	lipid metabolic process
B	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
B	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
B	0030392	biological_process	fructosamine catabolic process
B	0030424	cellular_component	axon
B	0036438	biological_process	maintenance of lens transparency
B	0042572	biological_process	retinol metabolic process
B	0045202	cellular_component	synapse
B	0051287	molecular_function	NAD binding
B	0070062	cellular_component	extracellular exosome
B	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
B	0110095	biological_process	cellular detoxification of aldehyde
B	0120163	biological_process	negative regulation of cold-induced thermogenesis
B	0140087	molecular_function	acetaldehyde dehydrogenase (NAD+) activity
C	0000166	molecular_function	nucleotide binding
C	0001523	biological_process	retinoid metabolic process
C	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0005096	molecular_function	GTPase activator activity
C	0005497	molecular_function	androgen binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006081	biological_process	aldehyde metabolic process
C	0006629	biological_process	lipid metabolic process
C	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
C	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
C	0030392	biological_process	fructosamine catabolic process
C	0030424	cellular_component	axon
C	0036438	biological_process	maintenance of lens transparency
C	0042572	biological_process	retinol metabolic process
C	0045202	cellular_component	synapse
C	0051287	molecular_function	NAD binding
C	0070062	cellular_component	extracellular exosome
C	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
C	0110095	biological_process	cellular detoxification of aldehyde
C	0120163	biological_process	negative regulation of cold-induced thermogenesis
C	0140087	molecular_function	acetaldehyde dehydrogenase (NAD+) activity
D	0000166	molecular_function	nucleotide binding
D	0001523	biological_process	retinoid metabolic process
D	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0005096	molecular_function	GTPase activator activity
D	0005497	molecular_function	androgen binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006081	biological_process	aldehyde metabolic process
D	0006629	biological_process	lipid metabolic process
D	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
D	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
D	0030392	biological_process	fructosamine catabolic process
D	0030424	cellular_component	axon
D	0036438	biological_process	maintenance of lens transparency
D	0042572	biological_process	retinol metabolic process
D	0045202	cellular_component	synapse
D	0051287	molecular_function	NAD binding
D	0070062	cellular_component	extracellular exosome
D	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
D	0110095	biological_process	cellular detoxification of aldehyde
D	0120163	biological_process	negative regulation of cold-induced thermogenesis
D	0140087	molecular_function	acetaldehyde dehydrogenase (NAD+) activity
E	0000166	molecular_function	nucleotide binding
E	0001523	biological_process	retinoid metabolic process
E	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
E	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
E	0005096	molecular_function	GTPase activator activity
E	0005497	molecular_function	androgen binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006081	biological_process	aldehyde metabolic process
E	0006629	biological_process	lipid metabolic process
E	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
E	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
E	0030392	biological_process	fructosamine catabolic process
E	0030424	cellular_component	axon
E	0036438	biological_process	maintenance of lens transparency
E	0042572	biological_process	retinol metabolic process
E	0045202	cellular_component	synapse
E	0051287	molecular_function	NAD binding
E	0070062	cellular_component	extracellular exosome
E	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
E	0110095	biological_process	cellular detoxification of aldehyde
E	0120163	biological_process	negative regulation of cold-induced thermogenesis
E	0140087	molecular_function	acetaldehyde dehydrogenase (NAD+) activity
F	0000166	molecular_function	nucleotide binding
F	0001523	biological_process	retinoid metabolic process
F	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
F	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
F	0005096	molecular_function	GTPase activator activity
F	0005497	molecular_function	androgen binding
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006081	biological_process	aldehyde metabolic process
F	0006629	biological_process	lipid metabolic process
F	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
F	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
F	0030392	biological_process	fructosamine catabolic process
F	0030424	cellular_component	axon
F	0036438	biological_process	maintenance of lens transparency
F	0042572	biological_process	retinol metabolic process
F	0045202	cellular_component	synapse
F	0051287	molecular_function	NAD binding
F	0070062	cellular_component	extracellular exosome
F	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
F	0110095	biological_process	cellular detoxification of aldehyde
F	0120163	biological_process	negative regulation of cold-induced thermogenesis
F	0140087	molecular_function	acetaldehyde dehydrogenase (NAD+) activity
G	0000166	molecular_function	nucleotide binding
G	0001523	biological_process	retinoid metabolic process
G	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
G	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
G	0005096	molecular_function	GTPase activator activity
G	0005497	molecular_function	androgen binding
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006081	biological_process	aldehyde metabolic process
G	0006629	biological_process	lipid metabolic process
G	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
G	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
G	0030392	biological_process	fructosamine catabolic process
G	0030424	cellular_component	axon
G	0036438	biological_process	maintenance of lens transparency
G	0042572	biological_process	retinol metabolic process
G	0045202	cellular_component	synapse
G	0051287	molecular_function	NAD binding
G	0070062	cellular_component	extracellular exosome
G	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
G	0110095	biological_process	cellular detoxification of aldehyde
G	0120163	biological_process	negative regulation of cold-induced thermogenesis
G	0140087	molecular_function	acetaldehyde dehydrogenase (NAD+) activity
H	0000166	molecular_function	nucleotide binding
H	0001523	biological_process	retinoid metabolic process
H	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
H	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
H	0005096	molecular_function	GTPase activator activity
H	0005497	molecular_function	androgen binding
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006081	biological_process	aldehyde metabolic process
H	0006629	biological_process	lipid metabolic process
H	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
H	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
H	0030392	biological_process	fructosamine catabolic process
H	0030424	cellular_component	axon
H	0036438	biological_process	maintenance of lens transparency
H	0042572	biological_process	retinol metabolic process
H	0045202	cellular_component	synapse
H	0051287	molecular_function	NAD binding
H	0070062	cellular_component	extracellular exosome
H	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
H	0110095	biological_process	cellular detoxification of aldehyde
H	0120163	biological_process	negative regulation of cold-induced thermogenesis
H	0140087	molecular_function	acetaldehyde dehydrogenase (NAD+) activity

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FyHQGQCCIAAS

Chain	Residue	Details
A	PHE296-SER307

---

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP

Chain	Residue	Details
A	LEU268-PRO275

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1320
Details	Region: {"description":"Mediates interaction with PRMT3","evidences":[{"source":"PubMed","id":"33495566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10008","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3676276","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10008","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3676276","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	128
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25450233","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25634381","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WB9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P20000","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	72
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---