8WFL
human glycine transporter 1 in complex with PF-03463275 in outward facing conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006836 | biological_process | neurotransmitter transport |
| A | 0006865 | biological_process | amino acid transport |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0015187 | molecular_function | glycine transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015375 | molecular_function | glycine:sodium symporter activity |
| A | 0015816 | biological_process | glycine transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016328 | cellular_component | lateral plasma membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030672 | cellular_component | synaptic vesicle membrane |
| A | 0031045 | cellular_component | dense core granule |
| A | 0032279 | cellular_component | asymmetric synapse |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042734 | cellular_component | presynaptic membrane |
| A | 0045211 | cellular_component | postsynaptic membrane |
| A | 0046985 | biological_process | positive regulation of hemoglobin biosynthetic process |
| A | 0060012 | biological_process | synaptic transmission, glycinergic |
| A | 0060092 | biological_process | regulation of synaptic transmission, glycinergic |
| A | 0070455 | biological_process | positive regulation of heme biosynthetic process |
| A | 0098686 | cellular_component | hippocampal mossy fiber to CA3 synapse |
| A | 0098688 | cellular_component | parallel fiber to Purkinje cell synapse |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1903804 | biological_process | glycine import across plasma membrane |
| A | 1904782 | biological_process | negative regulation of NMDA glutamate receptor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00610 |
| Number of Residues | 15 |
| Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcyrNGGGaF |
| Chain | Residue | Details |
| A | TRP70-PHE84 |
| site_id | PS00754 |
| Number of Residues | 21 |
| Details | NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YFfsSMThvLPWayCnnpwNT |
| Chain | Residue | Details |
| A | TYR152-THR172 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 107 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-GLN108 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE109-TYR129 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | THR136-SER156 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | SER188-THR208 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 76 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | SER209-GLY285 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA286-VAL306 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE315-HIS335 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE360-ASP380 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE407-VAL427 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL450-LEU470 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE506-SER526 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE530-GLN550 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE570-LEU590 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY610-HIS630 |
