8WBZ
Cryo-EM structure of ACE2-B0AT1 complex with JX225
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ |
Chain | Residue | Details |
B | THR371-GLN380 |
site_id | PS00610 |
Number of Residues | 15 |
Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcqsHGGGaF |
Chain | Residue | Details |
A | TRP56-PHE70 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1444 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
B | GLN18-SER740 | |
C | GLN18-SER740 |
site_id | SWS_FT_FI2 |
Number of Residues | 40 |
Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU01354 |
Chain | Residue | Details |
B | ILE741-ILE761 | |
D | GLY326-SER413 | |
D | GLY478-GLY490 | |
D | GLU553-TRP581 | |
C | ILE741-ILE761 | |
A | THR243-TRP268 | |
A | GLY326-SER413 | |
A | GLY478-GLY490 | |
A | GLU553-TRP581 | |
D | GLN63-GLY67 | |
D | ASN142-SER192 | |
D | THR243-TRP268 |
site_id | SWS_FT_FI3 |
Number of Residues | 86 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
B | PHE762-PHE805 | |
C | PHE762-PHE805 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895, ECO:0000305|PubMed:27217402 |
Chain | Residue | Details |
B | GLU375 | |
D | ASN435-GLU456 | |
D | ASP512-GLN531 | |
D | TYR603-TYR634 | |
C | GLU375 | |
A | SER290-VAL304 | |
A | ASN435-GLU456 | |
A | ASP512-GLN531 | |
A | TYR603-TYR634 | |
D | GLU89-LEU120 | |
D | ARG214-LYS221 | |
D | SER290-VAL304 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895 |
Chain | Residue | Details |
B | HIS505 | |
C | HIS505 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774 |
Chain | Residue | Details |
B | ARG169 | |
B | TRP477 | |
B | LYS481 | |
C | ARG169 | |
C | TRP477 | |
C | LYS481 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000305|PubMed:14754895 |
Chain | Residue | Details |
B | ARG273 | |
B | HIS345 | |
B | TYR515 | |
C | ARG273 | |
C | HIS345 | |
C | TYR515 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895 |
Chain | Residue | Details |
B | HIS374 | |
B | HIS378 | |
B | GLU402 | |
C | HIS374 | |
C | HIS378 | |
C | GLU402 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498 |
Chain | Residue | Details |
B | TYR781 | |
C | TYR781 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498 |
Chain | Residue | Details |
B | SER783 | |
C | SER783 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895 |
Chain | Residue | Details |
B | ASN53 | |
B | ASN322 | |
C | ASN53 | |
C | ASN322 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337 |
Chain | Residue | Details |
B | ASN90 | |
C | ASN90 |
site_id | SWS_FT_FI13 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895 |
Chain | Residue | Details |
B | ASN103 | |
B | ASN432 | |
C | ASN103 | |
C | ASN432 |
site_id | SWS_FT_FI14 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337 |
Chain | Residue | Details |
B | ASN546 | |
C | ASN546 |
site_id | SWS_FT_FI15 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
B | ASN690 | |
C | ASN690 | |
D | SER17 | |
D | SER627 |
site_id | SWS_FT_FI16 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36876523 |
Chain | Residue | Details |
B | LYS788 | |
D | ASN368 | |
A | ASN182 | |
C | LYS788 | |
A | ASN354 | |
A | ASN368 | |
D | ASN158 | |
D | ASN182 | |
D | ASN258 | |
D | ASN354 |