8WBZ
Cryo-EM structure of ACE2-B0AT1 complex with JX225
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003333 | biological_process | amino acid transmembrane transport |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006865 | biological_process | amino acid transport |
| A | 0007584 | biological_process | response to nutrient |
| A | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| A | 0015175 | molecular_function | neutral L-amino acid transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015804 | biological_process | neutral amino acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0019058 | biological_process | viral life cycle |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0031526 | cellular_component | brush border membrane |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008241 | molecular_function | peptidyl-dipeptidase activity |
| B | 0016020 | cellular_component | membrane |
| C | 0006508 | biological_process | proteolysis |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0008241 | molecular_function | peptidyl-dipeptidase activity |
| C | 0016020 | cellular_component | membrane |
| D | 0003333 | biological_process | amino acid transmembrane transport |
| D | 0005515 | molecular_function | protein binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006865 | biological_process | amino acid transport |
| D | 0007584 | biological_process | response to nutrient |
| D | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| D | 0015175 | molecular_function | neutral L-amino acid transmembrane transporter activity |
| D | 0015293 | molecular_function | symporter activity |
| D | 0015804 | biological_process | neutral amino acid transport |
| D | 0016020 | cellular_component | membrane |
| D | 0016324 | cellular_component | apical plasma membrane |
| D | 0019058 | biological_process | viral life cycle |
| D | 0022857 | molecular_function | transmembrane transporter activity |
| D | 0031526 | cellular_component | brush border membrane |
| D | 0035725 | biological_process | sodium ion transmembrane transport |
| D | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ |
| Chain | Residue | Details |
| B | THR371-GLN380 |
| site_id | PS00610 |
| Number of Residues | 15 |
| Details | NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcqsHGGGaF |
| Chain | Residue | Details |
| A | TRP56-PHE70 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1444 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | GLN18-SER740 | |
| C | GLN18-SER740 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU01354 |
| Chain | Residue | Details |
| B | ILE741-ILE761 | |
| D | GLY326-SER413 | |
| D | GLY478-GLY490 | |
| D | GLU553-TRP581 | |
| C | ILE741-ILE761 | |
| A | THR243-TRP268 | |
| A | GLY326-SER413 | |
| A | GLY478-GLY490 | |
| A | GLU553-TRP581 | |
| D | GLN63-GLY67 | |
| D | ASN142-SER192 | |
| D | THR243-TRP268 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 86 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE762-PHE805 | |
| C | PHE762-PHE805 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895, ECO:0000305|PubMed:27217402 |
| Chain | Residue | Details |
| B | GLU375 | |
| D | ASN435-GLU456 | |
| D | ASP512-GLN531 | |
| D | TYR603-TYR634 | |
| C | GLU375 | |
| A | SER290-VAL304 | |
| A | ASN435-GLU456 | |
| A | ASP512-GLN531 | |
| A | TYR603-TYR634 | |
| D | GLU89-LEU120 | |
| D | ARG214-LYS221 | |
| D | SER290-VAL304 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| B | HIS505 | |
| C | HIS505 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774 |
| Chain | Residue | Details |
| B | ARG169 | |
| B | TRP477 | |
| B | LYS481 | |
| C | ARG169 | |
| C | TRP477 | |
| C | LYS481 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| B | ARG273 | |
| B | HIS345 | |
| B | TYR515 | |
| C | ARG273 | |
| C | HIS345 | |
| C | TYR515 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895 |
| Chain | Residue | Details |
| B | HIS374 | |
| B | HIS378 | |
| B | GLU402 | |
| C | HIS374 | |
| C | HIS378 | |
| C | GLU402 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498 |
| Chain | Residue | Details |
| B | TYR781 | |
| C | TYR781 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498 |
| Chain | Residue | Details |
| B | SER783 | |
| C | SER783 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| B | ASN53 | |
| B | ASN322 | |
| C | ASN53 | |
| C | ASN322 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337 |
| Chain | Residue | Details |
| B | ASN90 | |
| C | ASN90 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895 |
| Chain | Residue | Details |
| B | ASN103 | |
| B | ASN432 | |
| C | ASN103 | |
| C | ASN432 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337 |
| Chain | Residue | Details |
| B | ASN546 | |
| C | ASN546 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN690 | |
| C | ASN690 | |
| D | SER17 | |
| D | SER627 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36876523 |
| Chain | Residue | Details |
| B | LYS788 | |
| D | ASN368 | |
| A | ASN182 | |
| C | LYS788 | |
| A | ASN354 | |
| A | ASN368 | |
| D | ASN158 | |
| D | ASN182 | |
| D | ASN258 | |
| D | ASN354 |
