Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8WB0

De novo transcribing complex 17 (TC17), the early elongation complex with Pol II positioned 17nt downstream of TSS

Functional Information from GO Data

Chain	GOid	namespace	contents
o	0000428	cellular_component	DNA-directed RNA polymerase complex
o	0001055	molecular_function	RNA polymerase II activity
o	0003677	molecular_function	DNA binding
o	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
o	0005634	cellular_component	nucleus
o	0005665	cellular_component	RNA polymerase II, core complex
o	0006351	biological_process	DNA-templated transcription
o	0006366	biological_process	transcription by RNA polymerase II
o	0016779	molecular_function	nucleotidyltransferase activity
o	0031981	cellular_component	nuclear lumen
o	0032991	cellular_component	protein-containing complex
o	0046872	molecular_function	metal ion binding
p	0000428	cellular_component	DNA-directed RNA polymerase complex
p	0000781	cellular_component	chromosome, telomeric region
p	0001055	molecular_function	RNA polymerase II activity
p	0001172	biological_process	RNA-templated transcription
p	0003677	molecular_function	DNA binding
p	0003682	molecular_function	chromatin binding
p	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
p	0003968	molecular_function	RNA-dependent RNA polymerase activity
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005665	cellular_component	RNA polymerase II, core complex
p	0006351	biological_process	DNA-templated transcription
p	0006366	biological_process	transcription by RNA polymerase II
p	0016779	molecular_function	nucleotidyltransferase activity
p	0032549	molecular_function	ribonucleoside binding
p	0034062	molecular_function	5'-3' RNA polymerase activity
p	0046872	molecular_function	metal ion binding
q	0000428	cellular_component	DNA-directed RNA polymerase complex
q	0003677	molecular_function	DNA binding
q	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005665	cellular_component	RNA polymerase II, core complex
q	0005829	cellular_component	cytosol
q	0006351	biological_process	DNA-templated transcription
q	0006366	biological_process	transcription by RNA polymerase II
q	0046983	molecular_function	protein dimerization activity
r	0000166	molecular_function	nucleotide binding
r	0005634	cellular_component	nucleus
r	0005665	cellular_component	RNA polymerase II, core complex
r	0006352	biological_process	DNA-templated transcription initiation
r	0006367	biological_process	transcription initiation at RNA polymerase II promoter
r	0030880	cellular_component	RNA polymerase complex
r	0031369	molecular_function	translation initiation factor binding
r	0044237	biological_process	cellular metabolic process
s	0001054	molecular_function	RNA polymerase I activity
s	0001055	molecular_function	RNA polymerase II activity
s	0001056	molecular_function	RNA polymerase III activity
s	0003677	molecular_function	DNA binding
s	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
s	0005634	cellular_component	nucleus
s	0005665	cellular_component	RNA polymerase II, core complex
s	0005666	cellular_component	RNA polymerase III complex
s	0005736	cellular_component	RNA polymerase I complex
s	0006351	biological_process	DNA-templated transcription
s	0006362	biological_process	transcription elongation by RNA polymerase I
s	0006366	biological_process	transcription by RNA polymerase II
s	0016591	cellular_component	RNA polymerase II, holoenzyme
s	0042797	biological_process	tRNA transcription by RNA polymerase III
S	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
S	0001096	molecular_function	TFIIF-class transcription factor complex binding
S	0003677	molecular_function	DNA binding
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005669	cellular_component	transcription factor TFIID complex
S	0005674	cellular_component	transcription factor TFIIF complex
S	0006366	biological_process	transcription by RNA polymerase II
S	0006367	biological_process	transcription initiation at RNA polymerase II promoter
S	0006368	biological_process	transcription elongation by RNA polymerase II
S	0009615	biological_process	response to virus
S	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
S	0019211	molecular_function	phosphatase activator activity
S	0019903	molecular_function	protein phosphatase binding
S	0019904	molecular_function	protein domain specific binding
S	0030054	cellular_component	cell junction
S	0032091	biological_process	negative regulation of protein binding
S	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
S	0032991	cellular_component	protein-containing complex
S	0043231	cellular_component	intracellular membrane-bounded organelle
S	0045944	biological_process	positive regulation of transcription by RNA polymerase II
S	1990841	molecular_function	promoter-specific chromatin binding
t	0000428	cellular_component	DNA-directed RNA polymerase complex
t	0001650	cellular_component	fibrillar center
t	0003677	molecular_function	DNA binding
t	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005665	cellular_component	RNA polymerase II, core complex
t	0005666	cellular_component	RNA polymerase III complex
t	0005736	cellular_component	RNA polymerase I complex
t	0006351	biological_process	DNA-templated transcription
t	0006366	biological_process	transcription by RNA polymerase II
T	0003677	molecular_function	DNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005674	cellular_component	transcription factor TFIIF complex
T	0006366	biological_process	transcription by RNA polymerase II
T	0006367	biological_process	transcription initiation at RNA polymerase II promoter
T	0006368	biological_process	transcription elongation by RNA polymerase II
T	0015630	cellular_component	microtubule cytoskeleton
T	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
T	0045944	biological_process	positive regulation of transcription by RNA polymerase II
u	0000428	cellular_component	DNA-directed RNA polymerase complex
u	0000932	cellular_component	P-body
u	0003676	molecular_function	nucleic acid binding
u	0003697	molecular_function	single-stranded DNA binding
u	0003727	molecular_function	single-stranded RNA binding
u	0005634	cellular_component	nucleus
u	0005665	cellular_component	RNA polymerase II, core complex
u	0006351	biological_process	DNA-templated transcription
u	0006352	biological_process	DNA-templated transcription initiation
u	0006367	biological_process	transcription initiation at RNA polymerase II promoter
u	0031369	molecular_function	translation initiation factor binding
u	0045948	biological_process	positive regulation of translational initiation
u	0060213	biological_process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
v	0000428	cellular_component	DNA-directed RNA polymerase complex
v	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
v	0005634	cellular_component	nucleus
v	0005665	cellular_component	RNA polymerase II, core complex
v	0006351	biological_process	DNA-templated transcription
w	0000428	cellular_component	DNA-directed RNA polymerase complex
w	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
w	0003676	molecular_function	nucleic acid binding
w	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
w	0005634	cellular_component	nucleus
w	0005654	cellular_component	nucleoplasm
w	0005665	cellular_component	RNA polymerase II, core complex
w	0005730	cellular_component	nucleolus
w	0006283	biological_process	transcription-coupled nucleotide-excision repair
w	0006351	biological_process	DNA-templated transcription
w	0006366	biological_process	transcription by RNA polymerase II
w	0006367	biological_process	transcription initiation at RNA polymerase II promoter
w	0008270	molecular_function	zinc ion binding
w	0016591	cellular_component	RNA polymerase II, holoenzyme
w	0046872	molecular_function	metal ion binding
x	0000428	cellular_component	DNA-directed RNA polymerase complex
x	0003677	molecular_function	DNA binding
x	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
x	0006351	biological_process	DNA-templated transcription
x	0008270	molecular_function	zinc ion binding
x	0046872	molecular_function	metal ion binding
y	0000428	cellular_component	DNA-directed RNA polymerase complex
y	0001055	molecular_function	RNA polymerase II activity
y	0003677	molecular_function	DNA binding
y	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
y	0005634	cellular_component	nucleus
y	0005665	cellular_component	RNA polymerase II, core complex
y	0006351	biological_process	DNA-templated transcription
y	0006366	biological_process	transcription by RNA polymerase II
y	0016591	cellular_component	RNA polymerase II, holoenzyme
y	0046983	molecular_function	protein dimerization activity
z	0001054	molecular_function	RNA polymerase I activity
z	0001055	molecular_function	RNA polymerase II activity
z	0001056	molecular_function	RNA polymerase III activity
z	0003677	molecular_function	DNA binding
z	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
z	0005665	cellular_component	RNA polymerase II, core complex
z	0005666	cellular_component	RNA polymerase III complex
z	0005736	cellular_component	RNA polymerase I complex
z	0006351	biological_process	DNA-templated transcription
z	0006360	biological_process	transcription by RNA polymerase I
z	0006366	biological_process	transcription by RNA polymerase II
z	0006383	biological_process	transcription by RNA polymerase III
z	0008270	molecular_function	zinc ion binding
z	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI

Chain	Residue	Details
q	ASP136-ILE148

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
o	TYR1593-ALA1599
o	TYR1671-SER1677
o	TYR1678-SER1684
o	TYR1685-SER1691
o	TYR1692-SER1698
o	TYR1699-SER1705
o	TYR1706-SER1712
o	TYR1713-SER1719
o	TYR1720-SER1726
o	TYR1727-SER1733
o	TYR1734-SER1740
o	TYR1615-SER1621
o	TYR1741-ASN1747
o	TYR1748-ASN1754
o	TYR1755-SER1761
o	TYR1762-SER1768
o	TYR1769-ASN1775
o	TYR1776-ASN1782
o	TYR1783-SER1789
o	TYR1790-SER1796
o	TYR1797-SER1803
o	TYR1818-SER1824
o	TYR1622-SER1628
o	TYR1825-SER1831
o	TYR1832-LYS1838
o	TYR1839-SER1845
o	TYR1853-LYS1859
o	TYR1860-LYS1866
o	TYR1867-LYS1873
o	TYR1874-THR1880
o	TYR1888-THR1894
o	TYR1902-LYS1908
o	TYR1909-THR1915
o	TYR1629-ASN1635
o	TYR1916-LYS1922
o	TYR1923-THR1929
o	TYR1930-LYS1936
o	TYR1947-THR1953
o	TYR1636-SER1642
o	TYR1643-SER1649
o	TYR1650-SER1656
o	TYR1657-SER1663
o	TYR1664-SER1670

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
w	TYR112-HIS118

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
q	ASN32-PRO72

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW

Chain	Residue	Details
w	CYS86-TRP123

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCqECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
w	PHE16-CYS42

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
s	HIS142-GLU155

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
t	THR58-GLN72

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
x	ILE2-GLY11

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
y	ILE35-PRO66

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
p	GLY932-THR944

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	ZN_FING: C4-type => ECO:0000255

Chain	Residue	Details
w	CYS17-CYS42
T	HIS229
S	GLU517

site_id	SWS_FT_FI2
Number of Residues	42
Details	ZN_FING: TFIIS-type => ECO:0000255\|PROSITE-ProRule:PRU00472

Chain	Residue	Details
w	GLU82-THR124

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P27999

Chain	Residue	Details
w	CYS17
w	CYS20
w	CYS39
w	CYS42

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00472

Chain	Residue	Details
w	CYS86
w	CYS89
w	CYS114
w	CYS119

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0000250\|UniProtKB:P36954

Chain	Residue	Details
w	MET1
S	SER224

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:20068231

Chain	Residue	Details
S	SER221

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:21406692

Chain	Residue	Details
S	THR331

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
S	SER377
S	SER431

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
S	SER380
S	SER381
S	SER436
S	SER449

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:10428810, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
S	SER385

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269\|PubMed:10428810, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
S	THR389

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:21406692

Chain	Residue	Details
S	SER391

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
S	LYS407

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:16964243, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
S	SER433

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
S	THR446

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)