8W3Z

Crystal structure of a computationally designed metalloprotein containing the metal-chelating, fluorogenic, non-canonical amino acid 3-(8-hydroxyquinolin-3-yl)-L-alanine: magnesium-bound form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000162	biological_process	L-tryptophan biosynthetic process
A	0004425	molecular_function	indole-3-glycerol-phosphate synthase activity
A	0006568	biological_process	L-tryptophan metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity

Functional Information from PROSITE/UniProt

site_id	PS00614
Number of Residues	15
Details	IGPS Indole-3-glycerol phosphate synthase signature. IIaEYKRKSPSgld....V

Chain	Residue	Details
A	ILE48-VAL62

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 252

Chain	Residue	Details
A	GLU51	electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity, proton acceptor, proton donor
A	LYS53	electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor
A	HQA110	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	GLU163	activator, hydrogen bond acceptor, increase nucleophilicity
A	GLU184	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase acidity
A	SER214	electrostatic stabiliser
A	GLU215	electrostatic stabiliser, hydrogen bond donor

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