8W2G
Human liver phosphofructokinase-1 in the R-state conformation
Functional Information from PROSITE/UniProt
| site_id | PS00433 |
| Number of Residues | 19 |
| Details | PHOSPHOFRUCTOKINASE Phosphofructokinase signature. RvtvlGHvQRGGtpsafDR |
| Chain | Residue | Details |
| A | ARG292-ARG310 | |
| A | ARG654-ARG672 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03184 |
| Chain | Residue | Details |
| A | ASP166 | |
| D | ASP166 | |
| B | ASP166 | |
| C | ASP166 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03184 |
| Chain | Residue | Details |
| A | GLY25 | |
| D | ARG88 | |
| D | GLY118 | |
| D | ASP119 | |
| D | ARG201 | |
| D | ARG292 | |
| D | ARG565 | |
| D | ARG654 | |
| B | GLY25 | |
| B | ARG88 | |
| B | GLY118 | |
| A | ARG88 | |
| B | ASP119 | |
| B | ARG201 | |
| B | ARG292 | |
| B | ARG565 | |
| B | ARG654 | |
| C | GLY25 | |
| C | ARG88 | |
| C | GLY118 | |
| C | ASP119 | |
| C | ARG201 | |
| A | GLY118 | |
| C | ARG292 | |
| C | ARG565 | |
| C | ARG654 | |
| A | ASP119 | |
| A | ARG201 | |
| A | ARG292 | |
| A | ARG565 | |
| A | ARG654 | |
| D | GLY25 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_03184 |
| Chain | Residue | Details |
| A | SER164 | |
| A | ARG734 | |
| D | SER164 | |
| D | MET208 | |
| D | GLU264 | |
| D | HIS298 | |
| D | ARG470 | |
| D | THR527 | |
| D | MET572 | |
| D | GLU628 | |
| D | HIS660 | |
| A | MET208 | |
| D | ARG734 | |
| B | SER164 | |
| B | MET208 | |
| B | GLU264 | |
| B | HIS298 | |
| B | ARG470 | |
| B | THR527 | |
| B | MET572 | |
| B | GLU628 | |
| B | HIS660 | |
| A | GLU264 | |
| B | ARG734 | |
| C | SER164 | |
| C | MET208 | |
| C | GLU264 | |
| C | HIS298 | |
| C | ARG470 | |
| C | THR527 | |
| C | MET572 | |
| C | GLU628 | |
| C | HIS660 | |
| A | HIS298 | |
| C | ARG734 | |
| A | ARG470 | |
| A | THR527 | |
| A | MET572 | |
| A | GLU628 | |
| A | HIS660 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.6, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | ALA2 | |
| D | ALA2 | |
| B | ALA2 | |
| C | ALA2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P47857 |
| Chain | Residue | Details |
| A | SER377 | |
| D | SER377 | |
| B | SER377 | |
| C | SER377 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P12382 |
| Chain | Residue | Details |
| A | TYR640 | |
| D | TYR640 | |
| B | TYR640 | |
| C | TYR640 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER775 | |
| D | SER775 | |
| B | SER775 | |
| C | SER775 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:22923583 |
| Chain | Residue | Details |
| A | SER529 | |
| D | SER529 | |
| B | SER529 | |
| C | SER529 |
