8VZJ

Crystal Structure of 2-Hydroxyacyl-CoA Lyase/Synthase DhcHACS from Dehalococcoidia bacterium in the Complex with THDP and ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0001561	biological_process	fatty acid alpha-oxidation
A	0003824	molecular_function	catalytic activity
A	0016830	molecular_function	carbon-carbon lyase activity
A	0030976	molecular_function	thiamine pyrophosphate binding
A	0046395	biological_process	carboxylic acid catabolic process
B	0000287	molecular_function	magnesium ion binding
B	0001561	biological_process	fatty acid alpha-oxidation
B	0003824	molecular_function	catalytic activity
B	0016830	molecular_function	carbon-carbon lyase activity
B	0030976	molecular_function	thiamine pyrophosphate binding
B	0046395	biological_process	carboxylic acid catabolic process
C	0000287	molecular_function	magnesium ion binding
C	0001561	biological_process	fatty acid alpha-oxidation
C	0003824	molecular_function	catalytic activity
C	0016830	molecular_function	carbon-carbon lyase activity
C	0030976	molecular_function	thiamine pyrophosphate binding
C	0046395	biological_process	carboxylic acid catabolic process
D	0000287	molecular_function	magnesium ion binding
D	0001561	biological_process	fatty acid alpha-oxidation
D	0003824	molecular_function	catalytic activity
D	0016830	molecular_function	carbon-carbon lyase activity
D	0030976	molecular_function	thiamine pyrophosphate binding
D	0046395	biological_process	carboxylic acid catabolic process
E	0000287	molecular_function	magnesium ion binding
E	0001561	biological_process	fatty acid alpha-oxidation
E	0003824	molecular_function	catalytic activity
E	0016830	molecular_function	carbon-carbon lyase activity
E	0030976	molecular_function	thiamine pyrophosphate binding
E	0046395	biological_process	carboxylic acid catabolic process
F	0000287	molecular_function	magnesium ion binding
F	0001561	biological_process	fatty acid alpha-oxidation
F	0003824	molecular_function	catalytic activity
F	0016830	molecular_function	carbon-carbon lyase activity
F	0030976	molecular_function	thiamine pyrophosphate binding
F	0046395	biological_process	carboxylic acid catabolic process
G	0000287	molecular_function	magnesium ion binding
G	0001561	biological_process	fatty acid alpha-oxidation
G	0003824	molecular_function	catalytic activity
G	0016830	molecular_function	carbon-carbon lyase activity
G	0030976	molecular_function	thiamine pyrophosphate binding
G	0046395	biological_process	carboxylic acid catabolic process
H	0000287	molecular_function	magnesium ion binding
H	0001561	biological_process	fatty acid alpha-oxidation
H	0003824	molecular_function	catalytic activity
H	0016830	molecular_function	carbon-carbon lyase activity
H	0030976	molecular_function	thiamine pyrophosphate binding
H	0046395	biological_process	carboxylic acid catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00187
Number of Residues	20
Details	TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IAaaavhPdkhvFcIeGDSA

Chain	Residue	Details
A	ILE424-ALA443

---