8VZI

Crystal Structure of 2-Hydroxyacyl-CoA Lyase/Synthase CcHACS from Conidiobolus coronatus in the Complex with THDP and ADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001561	biological_process	fatty acid alpha-oxidation
A	0003824	molecular_function	catalytic activity
A	0005777	cellular_component	peroxisome
A	0016829	molecular_function	lyase activity
A	0030976	molecular_function	thiamine pyrophosphate binding
A	0046872	molecular_function	metal ion binding
A	0106359	molecular_function	2-hydroxyacyl-CoA lyase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0001561	biological_process	fatty acid alpha-oxidation
B	0003824	molecular_function	catalytic activity
B	0005777	cellular_component	peroxisome
B	0016829	molecular_function	lyase activity
B	0030976	molecular_function	thiamine pyrophosphate binding
B	0046872	molecular_function	metal ion binding
B	0106359	molecular_function	2-hydroxyacyl-CoA lyase activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0001561	biological_process	fatty acid alpha-oxidation
C	0003824	molecular_function	catalytic activity
C	0005777	cellular_component	peroxisome
C	0016829	molecular_function	lyase activity
C	0030976	molecular_function	thiamine pyrophosphate binding
C	0046872	molecular_function	metal ion binding
C	0106359	molecular_function	2-hydroxyacyl-CoA lyase activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0001561	biological_process	fatty acid alpha-oxidation
D	0003824	molecular_function	catalytic activity
D	0005777	cellular_component	peroxisome
D	0016829	molecular_function	lyase activity
D	0030976	molecular_function	thiamine pyrophosphate binding
D	0046872	molecular_function	metal ion binding
D	0106359	molecular_function	2-hydroxyacyl-CoA lyase activity

Functional Information from PROSITE/UniProt

site_id	PS00187
Number of Residues	20
Details	TPP_ENZYMES Thiamine pyrophosphate enzymes signature. LAgqlthPdkkvVaImGDSA

Chain	Residue	Details
A	LEU426-ALA445

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