8VYV
Cryo-EM Structure of the BRAF K601E monomer
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 21 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGTVYkGkwhgd.............VAVK |
| Chain | Residue | Details |
| C | ILE829-LYS849 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKsnNIFL |
| Chain | Residue | Details |
| C | ILE938-LEU950 |
| site_id | PS00479 |
| Number of Residues | 46 |
| Details | ZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFvrktfftlaf.CdfCrklLfqgfr.....CqtCgykfHqrCstevplm..C |
| Chain | Residue | Details |
| C | HIS235-CYS280 |
| site_id | PS00796 |
| Number of Residues | 11 |
| Details | 1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV |
| Chain | Residue | Details |
| A | ARG41-VAL51 |
| site_id | PS00797 |
| Number of Residues | 20 |
| Details | 1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS |
| Chain | Residue | Details |
| A | TYR211-SER230 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 46 |
| Details | ZN_FING: Phorbol-ester/DAG-type => ECO:0000255|PROSITE-ProRule:PRU00226 |
| Chain | Residue | Details |
| C | THR234-CYS280 | |
| A | ARG127 | |
| B | ARG56 | |
| B | ARG127 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| C | ASP942 | |
| B | MET1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| C | HIS235 | |
| C | CYS248 | |
| C | CYS251 | |
| C | CYS261 | |
| C | CYS264 | |
| C | HIS269 | |
| C | CYS272 | |
| C | CYS280 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| C | ILE829 | |
| C | LYS849 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Breakpoint for translocation to form KIAA1549-BRAF fusion protein |
| Chain | Residue | Details |
| C | ASP746 | |
| C | MET804 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| C | ALA2 | |
| B | SER207 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | SER151 | |
| B | SER210 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P28028 |
| Chain | Residue | Details |
| C | SER333 | |
| C | SER1158 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by SGK1 => ECO:0000269|PubMed:11410590, ECO:0000269|Ref.8, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SEP365 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:1508179 |
| Chain | Residue | Details |
| C | THR739 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| C | THR762 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| C | SER765 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|Ref.8, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | THR767 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER812 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| C | SER813 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714 |
| Chain | Residue | Details |
| C | ARG1037 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|Ref.8, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SEP1137 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by MAPK1 => ECO:0000269|PubMed:19710016 |
| Chain | Residue | Details |
| C | THR1161 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581 |
| Chain | Residue | Details |
| C | LYS944 |
