8VYL
The structure of Human Hemoglobin in Complex with Nanobody BtNbE11
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | VAL1 | |
| B | HIS2 | |
| B | LYS82 | |
| B | HIS143 | |
| D | VAL1 | |
| D | HIS2 | |
| D | LYS82 | |
| D | HIS143 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: distal binding residue |
| Chain | Residue | Details |
| B | HIS63 | |
| D | HIS63 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: proximal binding residue |
| Chain | Residue | Details |
| B | HIS92 | |
| A | LEU91 | |
| A | LEU106 | |
| A | THR108 | |
| A | VAL121 | |
| A | SER133 | |
| C | THR8 | |
| C | ALA13 | |
| C | TYR24 | |
| C | LEU29 | |
| C | HIS45 | |
| D | HIS92 | |
| C | ASP47 | |
| C | SER52 | |
| C | VAL55 | |
| C | GLY59 | |
| C | LEU91 | |
| C | LEU106 | |
| C | THR108 | |
| C | VAL121 | |
| C | SER133 | |
| A | TYR24 | |
| A | LEU29 | |
| A | HIS45 | |
| A | ASP47 | |
| A | SER52 | |
| A | VAL55 | |
| A | GLY59 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | SITE: (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433 |
| Chain | Residue | Details |
| B | GLU7 | |
| B | GLY74 | |
| B | THR84 | |
| B | HIS92 | |
| B | ARG104 | |
| B | LEU110 | |
| B | GLY119 | |
| B | PHE122 | |
| B | ALA128 | |
| B | ALA140 | |
| B | LYS144 | |
| B | GLY25 | |
| D | GLU7 | |
| D | GLY25 | |
| D | GLY29 | |
| D | TYR35 | |
| D | TRP37 | |
| D | PHE45 | |
| D | ASP52 | |
| D | GLY56 | |
| D | PHE71 | |
| D | GLY74 | |
| B | GLY29 | |
| D | THR84 | |
| D | HIS92 | |
| D | ARG104 | |
| D | LEU110 | |
| D | GLY119 | |
| D | PHE122 | |
| D | ALA128 | |
| D | ALA140 | |
| D | LYS144 | |
| B | TYR35 | |
| B | TRP37 | |
| B | PHE45 | |
| B | ASP52 | |
| B | GLY56 | |
| B | PHE71 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:7358733 |
| Chain | Residue | Details |
| B | LYS59 | |
| B | LYS82 | |
| B | LYS95 | |
| D | LYS59 | |
| D | LYS82 | |
| D | LYS95 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N-pyruvate 2-iminyl-valine; in Hb A1b |
| Chain | Residue | Details |
| B | VAL1 | |
| D | VAL1 | |
| A | LYS40 | |
| C | LYS7 | |
| C | LYS16 | |
| C | LYS40 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER9 | |
| B | SER44 | |
| D | SER9 | |
| D | SER44 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | THR12 | |
| B | THR50 | |
| B | THR87 | |
| D | THR12 | |
| D | THR50 | |
| D | THR87 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:4531009 |
| Chain | Residue | Details |
| B | LYS59 | |
| B | LYS82 | |
| D | LYS59 | |
| D | LYS82 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 |
| Chain | Residue | Details |
| B | CYS93 | |
| D | CYS93 | |
| A | SER131 | |
| A | SER138 | |
| C | SER102 | |
| C | SER124 | |
| C | SER131 | |
| C | SER138 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009 |
| Chain | Residue | Details |
| B | LYS144 | |
| D | LYS144 | |
| A | THR137 | |
| C | THR108 | |
| C | THR134 | |
| C | THR137 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 |
| Chain | Residue | Details |
| B | VAL1 | |
| D | VAL1 | |
| A | LYS40 | |
| C | LYS7 | |
| C | LYS16 | |
| C | LYS40 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 |
| Chain | Residue | Details |
| B | LYS8 | |
| B | LYS17 | |
| B | LYS66 | |
| B | LYS120 | |
| D | LYS8 | |
| D | LYS17 | |
| D | LYS66 | |
| D | LYS120 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 |
| Chain | Residue | Details |
| B | LYS144 | |
| D | LYS144 |
