8VVX

Human Aquaporin 2 from 2D electron diffraction data

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003091	biological_process	renal water homeostasis
A	0005372	molecular_function	water transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0006833	biological_process	water transport
A	0007015	biological_process	actin filament organization
A	0015168	molecular_function	glycerol transmembrane transporter activity
A	0015250	molecular_function	water channel activity
A	0015267	molecular_function	channel activity
A	0015793	biological_process	glycerol transmembrane transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0030658	cellular_component	transport vesicle membrane
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051289	biological_process	protein homotetramerization
A	0055037	cellular_component	recycling endosome
A	0055085	biological_process	transmembrane transport
A	0070062	cellular_component	extracellular exosome
A	0071280	biological_process	cellular response to copper ion
A	0071288	biological_process	cellular response to mercury ion
A	0072205	biological_process	metanephric collecting duct development
A	0098576	cellular_component	lumenal side of membrane
B	0003091	biological_process	renal water homeostasis
B	0005372	molecular_function	water transmembrane transporter activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0006833	biological_process	water transport
B	0007015	biological_process	actin filament organization
B	0015168	molecular_function	glycerol transmembrane transporter activity
B	0015250	molecular_function	water channel activity
B	0015267	molecular_function	channel activity
B	0015793	biological_process	glycerol transmembrane transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0016324	cellular_component	apical plasma membrane
B	0030658	cellular_component	transport vesicle membrane
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051289	biological_process	protein homotetramerization
B	0055037	cellular_component	recycling endosome
B	0055085	biological_process	transmembrane transport
B	0070062	cellular_component	extracellular exosome
B	0071280	biological_process	cellular response to copper ion
B	0071288	biological_process	cellular response to mercury ion
B	0072205	biological_process	metanephric collecting duct development
B	0098576	cellular_component	lumenal side of membrane
X	0003091	biological_process	renal water homeostasis
X	0005372	molecular_function	water transmembrane transporter activity
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005794	cellular_component	Golgi apparatus
X	0005886	cellular_component	plasma membrane
X	0006833	biological_process	water transport
X	0007015	biological_process	actin filament organization
X	0015168	molecular_function	glycerol transmembrane transporter activity
X	0015250	molecular_function	water channel activity
X	0015267	molecular_function	channel activity
X	0015793	biological_process	glycerol transmembrane transport
X	0016020	cellular_component	membrane
X	0016323	cellular_component	basolateral plasma membrane
X	0016324	cellular_component	apical plasma membrane
X	0030658	cellular_component	transport vesicle membrane
X	0030659	cellular_component	cytoplasmic vesicle membrane
X	0031410	cellular_component	cytoplasmic vesicle
X	0048471	cellular_component	perinuclear region of cytoplasm
X	0051289	biological_process	protein homotetramerization
X	0055037	cellular_component	recycling endosome
X	0055085	biological_process	transmembrane transport
X	0070062	cellular_component	extracellular exosome
X	0071280	biological_process	cellular response to copper ion
X	0071288	biological_process	cellular response to mercury ion
X	0072205	biological_process	metanephric collecting duct development
X	0098576	cellular_component	lumenal side of membrane
Y	0003091	biological_process	renal water homeostasis
Y	0005372	molecular_function	water transmembrane transporter activity
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0005794	cellular_component	Golgi apparatus
Y	0005886	cellular_component	plasma membrane
Y	0006833	biological_process	water transport
Y	0007015	biological_process	actin filament organization
Y	0015168	molecular_function	glycerol transmembrane transporter activity
Y	0015250	molecular_function	water channel activity
Y	0015267	molecular_function	channel activity
Y	0015793	biological_process	glycerol transmembrane transport
Y	0016020	cellular_component	membrane
Y	0016323	cellular_component	basolateral plasma membrane
Y	0016324	cellular_component	apical plasma membrane
Y	0030658	cellular_component	transport vesicle membrane
Y	0030659	cellular_component	cytoplasmic vesicle membrane
Y	0031410	cellular_component	cytoplasmic vesicle
Y	0048471	cellular_component	perinuclear region of cytoplasm
Y	0051289	biological_process	protein homotetramerization
Y	0055037	cellular_component	recycling endosome
Y	0055085	biological_process	transmembrane transport
Y	0070062	cellular_component	extracellular exosome
Y	0071280	biological_process	cellular response to copper ion
Y	0071288	biological_process	cellular response to mercury ion
Y	0072205	biological_process	metanephric collecting duct development
Y	0098576	cellular_component	lumenal side of membrane

Functional Information from PROSITE/UniProt

site_id	PS00221
Number of Residues	9
Details	MIP MIP family signature. HINPAVTVA

Chain	Residue	Details
X	HIS66-ALA74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	472
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"24733887","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NEF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	144
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24733887","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	84
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24733887","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	84
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"24733887","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NEF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Motif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"24733887","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Motif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"24733887","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"12194985","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---