8VVC
Cryo-EM structure of human ABC transporter (hABCC1) with nucleotide-binding domain 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006691 | biological_process | leukotriene metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0006869 | biological_process | lipid transport |
| A | 0008559 | molecular_function | ABC-type xenobiotic transporter activity |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0015420 | molecular_function | ABC-type vitamin B12 transporter activity |
| A | 0015431 | molecular_function | ABC-type glutathione S-conjugate transporter activity |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0015889 | biological_process | cobalamin transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016328 | cellular_component | lateral plasma membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030148 | biological_process | sphingolipid biosynthetic process |
| A | 0034040 | molecular_function | ATPase-coupled lipid transmembrane transporter activity |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0034634 | molecular_function | glutathione transmembrane transporter activity |
| A | 0034775 | biological_process | glutathione transmembrane transport |
| A | 0042167 | biological_process | heme catabolic process |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0043225 | molecular_function | ATPase-coupled inorganic anion transmembrane transporter activity |
| A | 0045332 | biological_process | phospholipid translocation |
| A | 0046624 | molecular_function | sphingolipid transporter activity |
| A | 0046942 | biological_process | carboxylic acid transport |
| A | 0046943 | molecular_function | carboxylic acid transmembrane transporter activity |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070633 | biological_process | transepithelial transport |
| A | 0070729 | biological_process | cyclic nucleotide transport |
| A | 0071716 | biological_process | leukotriene transport |
| A | 0098656 | biological_process | monoatomic anion transmembrane transport |
| A | 0099039 | biological_process | sphingolipid translocation |
| A | 0140115 | biological_process | export across plasma membrane |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1904646 | biological_process | cellular response to amyloid-beta |
| A | 1905039 | biological_process | carboxylic acid transmembrane transport |
| A | 1990962 | biological_process | xenobiotic transport across blood-brain barrier |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 26 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGCGKSSLLSaLlaemdkvegh........VAIK |
| Chain | Residue | Details |
| A | VAL680-LYS705 |
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRVSLARAV |
| Chain | Residue | Details |
| A | LEU768-VAL782 | |
| A | LEU1430-LEU1444 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 139 |
| Details | TOPO_DOM: Extracellular |
| Chain | Residue | Details |
| A | MET1-PHE33 | |
| A | ARG96-ILE100 | |
| A | SER155-ASP172 | |
| A | MET338-GLY363 | |
| A | LEU462-PRO464 | |
| A | VAL569-ASN590 | |
| A | ALA989-SER1025 | |
| A | ALA1111 | |
| A | LEU1225-SER1226 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 |
| Chain | Residue | Details |
| A | GLN34-PHE54 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1018 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | LEU55-LYS74 | |
| A | PHE122-GLN133 | |
| A | ARG194-VAL316 | |
| A | PHE385-TYR440 | |
| A | LYS486-ALA547 | |
| A | SER612-MET967 | |
| A | CYS1047-GLU1089 | |
| A | TYR1133-LEU1203 | |
| A | VAL1248-VAL1531 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 |
| Chain | Residue | Details |
| A | THR75-GLU95 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 |
| Chain | Residue | Details |
| A | PHE101-THR121 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 |
| Chain | Residue | Details |
| A | SER134-ARG154 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 |
| Chain | Residue | Details |
| A | ILE173-ASP193 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 |
| Chain | Residue | Details |
| A | LEU317-LEU337 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 |
| Chain | Residue | Details |
| A | TYR364-TYR384 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=8 |
| Chain | Residue | Details |
| A | ILE441-ASN461 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 |
| Chain | Residue | Details |
| A | SER465-MET485 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 |
| Chain | Residue | Details |
| A | VAL548-TYR568 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 |
| Chain | Residue | Details |
| A | ILE591-VAL611 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 |
| Chain | Residue | Details |
| A | LYS968-SER988 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=13 |
| Chain | Residue | Details |
| A | GLN1026-ARG1046 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=14 |
| Chain | Residue | Details |
| A | VAL1090-LEU1110 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=15 |
| Chain | Residue | Details |
| A | THR1112-PHE1132 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=16 |
| Chain | Residue | Details |
| A | GLU1204-SER1224 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=17 |
| Chain | Residue | Details |
| A | ALA1227-LEU1247 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 3 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | TRP653 | |
| A | GLY678 | |
| A | GLN713 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| A | GLY1327 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O35379 |
| Chain | Residue | Details |
| A | TYR277 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O35379 |
| Chain | Residue | Details |
| A | SER289 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:O35379 |
| Chain | Residue | Details |
| A | LYS503 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER905 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER915 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | SER930 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:9295302 |
| Chain | Residue | Details |
| A | ASN19 | |
| A | ASN23 | |
| A | ASN1006 |
