8VUN
Human GluN1-2A With Fab 008-218
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH |
| Chain | Residue | Details |
| I | TYR191-HIS197 | |
| G | TYR203-HIS209 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 118 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:B7ZSK1 |
| Chain | Residue | Details |
| B | SER556-PHE576 | |
| B | THR606-TYR625 | |
| B | MET790-TRP810 | |
| D | SER556-PHE576 | |
| D | THR606-TYR625 | |
| D | MET790-TRP810 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:B7ZSK1 |
| Chain | Residue | Details |
| B | GLU577-THR580 | |
| B | ASN601-THR605 | |
| D | GLU577-THR580 | |
| D | ASN601-THR605 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 38 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:B7ZSK1 |
| Chain | Residue | Details |
| B | ILE581-GLN600 | |
| D | ILE581-GLN600 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 340 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:B7ZSK1 |
| Chain | Residue | Details |
| B | THR626-ASN789 | |
| D | THR626-ASN789 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q00959 |
| Chain | Residue | Details |
| B | HIS44 | |
| D | ASP282 | |
| D | SER669 | |
| D | TYR710 | |
| B | HIS128 | |
| B | GLU266 | |
| B | ASP282 | |
| B | SER669 | |
| B | TYR710 | |
| D | HIS44 | |
| D | HIS128 | |
| D | GLU266 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA |
| Chain | Residue | Details |
| B | SER511 | |
| A | ASN491 | |
| A | ASN655 | |
| A | ASN752 | |
| C | ASN61 | |
| C | ASN203 | |
| C | ASN239 | |
| C | ASN276 | |
| C | ASN300 | |
| C | ASN350 | |
| C | ASN368 | |
| B | ARG518 | |
| C | ASN440 | |
| C | ASN471 | |
| C | ASN491 | |
| C | ASN655 | |
| C | ASN752 | |
| D | SER511 | |
| D | ARG518 | |
| A | ASN300 | |
| A | ASN350 | |
| A | ASN368 | |
| A | ASN440 | |
| A | ASN471 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Functional determinant of NMDA receptors => ECO:0000250 |
| Chain | Residue | Details |
| B | ASN594 | |
| D | ASN594 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 14 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN75 | |
| D | ASN380 | |
| D | ASN443 | |
| D | ASN444 | |
| D | ASN541 | |
| D | ASN667 | |
| B | ASN340 | |
| B | ASN380 | |
| B | ASN443 | |
| B | ASN444 | |
| B | ASN541 | |
| B | ASN667 | |
| D | ASN75 | |
| D | ASN340 |
