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8VT7

Structure of the gamma tubulin ring complex nucleated microtubule protofilament.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000226biological_processmicrotubule cytoskeleton organization
A0000278biological_processmitotic cell cycle
A0003924molecular_functionGTPase activity
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0007017biological_processmicrotubule-based process
A0007411biological_processaxon guidance
A0015630cellular_componentmicrotubule cytoskeleton
A0030027cellular_componentlamellipodium
A0030175cellular_componentfilopodium
A0030182biological_processneuron differentiation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030426cellular_componentgrowth cone
A0038007biological_processnetrin-activated signaling pathway
A0042277molecular_functionpeptide binding
A0042995cellular_componentcell projection
A0043025cellular_componentneuronal cell body
A0045171cellular_componentintercellular bridge
A0046872molecular_functionmetal ion binding
A0070062cellular_componentextracellular exosome
A0071944cellular_componentcell periphery
A0072686cellular_componentmitotic spindle
A1990791biological_processdorsal root ganglion development
A1990890molecular_functionnetrin receptor binding
B0000166molecular_functionnucleotide binding
B0000226biological_processmicrotubule cytoskeleton organization
B0000278biological_processmitotic cell cycle
B0003725molecular_functiondouble-stranded RNA binding
B0003924molecular_functionGTPase activity
B0005198molecular_functionstructural molecule activity
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0005881cellular_componentcytoplasmic microtubule
B0005929cellular_componentcilium
B0007017biological_processmicrotubule-based process
B0015630cellular_componentmicrotubule cytoskeleton
B0016787molecular_functionhydrolase activity
B0030705biological_processcytoskeleton-dependent intracellular transport
B0031625molecular_functionubiquitin protein ligase binding
B0051301biological_processcell division
B0071353biological_processcellular response to interleukin-4
F0000166molecular_functionnucleotide binding
F0000226biological_processmicrotubule cytoskeleton organization
F0000278biological_processmitotic cell cycle
F0003924molecular_functionGTPase activity
F0005200molecular_functionstructural constituent of cytoskeleton
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005856cellular_componentcytoskeleton
F0005874cellular_componentmicrotubule
F0007017biological_processmicrotubule-based process
F0007411biological_processaxon guidance
F0015630cellular_componentmicrotubule cytoskeleton
F0030027cellular_componentlamellipodium
F0030175cellular_componentfilopodium
F0030182biological_processneuron differentiation
F0030424cellular_componentaxon
F0030425cellular_componentdendrite
F0030426cellular_componentgrowth cone
F0038007biological_processnetrin-activated signaling pathway
F0042277molecular_functionpeptide binding
F0042995cellular_componentcell projection
F0043025cellular_componentneuronal cell body
F0045171cellular_componentintercellular bridge
F0046872molecular_functionmetal ion binding
F0070062cellular_componentextracellular exosome
F0071944cellular_componentcell periphery
F0072686cellular_componentmitotic spindle
F1990791biological_processdorsal root ganglion development
F1990890molecular_functionnetrin receptor binding
J0000166molecular_functionnucleotide binding
J0000226biological_processmicrotubule cytoskeleton organization
J0000278biological_processmitotic cell cycle
J0003725molecular_functiondouble-stranded RNA binding
J0003924molecular_functionGTPase activity
J0005198molecular_functionstructural molecule activity
J0005200molecular_functionstructural constituent of cytoskeleton
J0005515molecular_functionprotein binding
J0005525molecular_functionGTP binding
J0005737cellular_componentcytoplasm
J0005856cellular_componentcytoskeleton
J0005874cellular_componentmicrotubule
J0005881cellular_componentcytoplasmic microtubule
J0005929cellular_componentcilium
J0007017biological_processmicrotubule-based process
J0015630cellular_componentmicrotubule cytoskeleton
J0016787molecular_functionhydrolase activity
J0030705biological_processcytoskeleton-dependent intracellular transport
J0031625molecular_functionubiquitin protein ligase binding
J0051301biological_processcell division
J0071353biological_processcellular response to interleukin-4
Functional Information from PROSITE/UniProt
site_idPS00227
Number of Residues7
DetailsTUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG
ChainResidueDetails
FGLY140-GLY146
JGLY142-GLY148

site_idPS00228
Number of Residues4
DetailsTUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI
ChainResidueDetails
FMET1-ILE4

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:34996871
ChainResidueDetails
JASP254
AGLY144
AASN204
AASN226
BASP254
FTHR143
FGLY144
FASN204
FASN226
AGLN11
AGLY142
ATHR143

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:35482892, ECO:0007744|PDB:7SJ7, ECO:0007744|PDB:7Z6S
ChainResidueDetails
JGLN11
BGLU71
BSER140
BGLY144
BTHR145
BTHR179
BASN206
BASN228
JGLU71
JSER140
JGLY144
JTHR145
JTHR179
JASN206
JASN228
BGLN11

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Involved in polymerization
ChainResidueDetails
JTYR451
BTYR451

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:24906155
ChainResidueDetails
JLYS37
BLYS37

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|Ref.6
ChainResidueDetails
JSER48
JSER232
BSER48
BSER232

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P68373
ChainResidueDetails
JTYR282
BTYR282

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000269|Ref.6
ChainResidueDetails
JARG339
BARG339

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68373
ChainResidueDetails
JSER439
BSER439

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: 5-glutamyl polyglutamate => ECO:0000269|PubMed:32747782
ChainResidueDetails
JGLU443
BGLU443

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:P68369
ChainResidueDetails
JGLU445
BGLU445

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000269|PubMed:10339593
ChainResidueDetails
JTYR451
BTYR451

site_idSWS_FT_FI12
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
JLYS326
JLYS370
BLYS326
BLYS370

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PDB entries from 2025-06-11

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