8VT4
Cryo-EM structure of human ABC transporter ABCC1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006691 | biological_process | leukotriene metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0008559 | molecular_function | ABC-type xenobiotic transporter activity |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0015420 | molecular_function | ABC-type vitamin B12 transporter activity |
| A | 0015431 | molecular_function | ABC-type glutathione S-conjugate transporter activity |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0015889 | biological_process | cobalamin transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016328 | cellular_component | lateral plasma membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030054 | cellular_component | cell junction |
| A | 0030148 | biological_process | sphingolipid biosynthetic process |
| A | 0034040 | molecular_function | ATPase-coupled lipid transmembrane transporter activity |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0034634 | molecular_function | glutathione transmembrane transporter activity |
| A | 0034775 | biological_process | glutathione transmembrane transport |
| A | 0042167 | biological_process | heme catabolic process |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0045332 | biological_process | phospholipid translocation |
| A | 0046942 | biological_process | carboxylic acid transport |
| A | 0046943 | molecular_function | carboxylic acid transmembrane transporter activity |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070633 | biological_process | transepithelial transport |
| A | 0070729 | biological_process | cyclic nucleotide transport |
| A | 0071716 | biological_process | leukotriene transport |
| A | 0099039 | biological_process | sphingolipid translocation |
| A | 0140115 | biological_process | export across plasma membrane |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1904646 | biological_process | cellular response to amyloid-beta |
| A | 1905039 | biological_process | carboxylic acid transmembrane transport |
| A | 1990962 | biological_process | xenobiotic transport across blood-brain barrier |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006691 | biological_process | leukotriene metabolic process |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0008559 | molecular_function | ABC-type xenobiotic transporter activity |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009925 | cellular_component | basal plasma membrane |
| B | 0015420 | molecular_function | ABC-type vitamin B12 transporter activity |
| B | 0015431 | molecular_function | ABC-type glutathione S-conjugate transporter activity |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0015889 | biological_process | cobalamin transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0016328 | cellular_component | lateral plasma membrane |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0030054 | cellular_component | cell junction |
| B | 0030148 | biological_process | sphingolipid biosynthetic process |
| B | 0034040 | molecular_function | ATPase-coupled lipid transmembrane transporter activity |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0034634 | molecular_function | glutathione transmembrane transporter activity |
| B | 0034775 | biological_process | glutathione transmembrane transport |
| B | 0042167 | biological_process | heme catabolic process |
| B | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0045332 | biological_process | phospholipid translocation |
| B | 0046942 | biological_process | carboxylic acid transport |
| B | 0046943 | molecular_function | carboxylic acid transmembrane transporter activity |
| B | 0050729 | biological_process | positive regulation of inflammatory response |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0060326 | biological_process | cell chemotaxis |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070633 | biological_process | transepithelial transport |
| B | 0070729 | biological_process | cyclic nucleotide transport |
| B | 0071716 | biological_process | leukotriene transport |
| B | 0099039 | biological_process | sphingolipid translocation |
| B | 0140115 | biological_process | export across plasma membrane |
| B | 0140359 | molecular_function | ABC-type transporter activity |
| B | 0150104 | biological_process | transport across blood-brain barrier |
| B | 1904646 | biological_process | cellular response to amyloid-beta |
| B | 1905039 | biological_process | carboxylic acid transmembrane transport |
| B | 1990962 | biological_process | xenobiotic transport across blood-brain barrier |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 364 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 344 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 30 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 30 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 30 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 30 |
| Details | Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical; Name=14","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=15","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=16","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=17","evidences":[{"source":"PubMed","id":"39765229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT4","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 448 |
| Details | Domain: {"description":"ABC transporter 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8HXQ5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"9295302","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
