8VSZ

CryoEM structure of human GABAA receptor pi (GABRP) apo state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0004890	molecular_function	GABA-A receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0004890	molecular_function	GABA-A receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0004890	molecular_function	GABA-A receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0004890	molecular_function	GABA-A receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0004890	molecular_function	GABA-A receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CnMdLskYPmDtqtC

Chain	Residue	Details
A	CYS160-CYS174

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1135
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	SER24-ASN241
E	GLY291-CYS301
A	GLY291-CYS301
B	SER24-ASN241
B	GLY291-CYS301
C	SER24-ASN241
C	GLY291-CYS301
D	SER24-ASN241
D	GLY291-CYS301
E	SER24-ASN241

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site_id	SWS_FT_FI2
Number of Residues	395
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	VAL242-VAL262
C	VAL271-ILE290
C	PHE302-LEU322
C	LEU420-PHE440
D	VAL242-VAL262
D	VAL271-ILE290
D	PHE302-LEU322
D	LEU420-PHE440
E	VAL242-VAL262
E	VAL271-ILE290
E	PHE302-LEU322
A	VAL271-ILE290
E	LEU420-PHE440
A	PHE302-LEU322
A	LEU420-PHE440
B	VAL242-VAL262
B	VAL271-ILE290
B	PHE302-LEU322
B	LEU420-PHE440
C	VAL242-VAL262

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site_id	SWS_FT_FI3
Number of Residues	515
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	SER263-SER270
E	GLU323-LYS419
A	GLU323-LYS419
B	SER263-SER270
B	GLU323-LYS419
C	SER263-SER270
C	GLU323-LYS419
D	SER263-SER270
D	GLU323-LYS419
E	SER263-SER270

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site_id	SWS_FT_FI4
Number of Residues	25
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN43
B	ASN228
C	ASN43
C	ASN102
C	ASN145
C	ASN196
C	ASN228
D	ASN43
D	ASN102
D	ASN145
D	ASN196
A	ASN102
D	ASN228
E	ASN43
E	ASN102
E	ASN145
E	ASN196
E	ASN228
A	ASN145
A	ASN196
A	ASN228
B	ASN43
B	ASN102
B	ASN145
B	ASN196

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