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8VSB

L-TGF-b3/GARP

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001701biological_processin utero embryonic development
A0005114molecular_functiontype II transforming growth factor beta receptor binding
A0005125molecular_functioncytokine activity
A0005160molecular_functiontransforming growth factor beta receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005886cellular_componentplasma membrane
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0007435biological_processsalivary gland morphogenesis
A0007507biological_processheart development
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010936biological_processnegative regulation of macrophage cytokine production
A0030879biological_processmammary gland development
A0031012cellular_componentextracellular matrix
A0031093cellular_componentplatelet alpha granule lumen
A0032570biological_processresponse to progesterone
A0032967biological_processpositive regulation of collagen biosynthetic process
A0034713molecular_functiontype I transforming growth factor beta receptor binding
A0034714molecular_functiontype III transforming growth factor beta receptor binding
A0042127biological_processregulation of cell population proliferation
A0042476biological_processodontogenesis
A0042704biological_processuterine wall breakdown
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0045216biological_processcell-cell junction organization
A0045597biological_processpositive regulation of cell differentiation
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048286biological_processlung alveolus development
A0050431molecular_functiontransforming growth factor beta binding
A0050714biological_processpositive regulation of protein secretion
A0051130biological_processpositive regulation of cellular component organization
A0051240biological_processpositive regulation of multicellular organismal process
A0051491biological_processpositive regulation of filopodium assembly
A0051496biological_processpositive regulation of stress fiber assembly
A0051781biological_processpositive regulation of cell division
A0060325biological_processface morphogenesis
A0060391biological_processpositive regulation of SMAD protein signal transduction
A0062009biological_processsecondary palate development
A0070483biological_processdetection of hypoxia
A0071363biological_processcellular response to growth factor stimulus
A0141091biological_processtransforming growth factor beta receptor superfamily signaling pathway
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
A1905005biological_processregulation of epithelial to mesenchymal transition involved in endocardial cushion formation
A1905075biological_processpositive regulation of tight junction disassembly
B0001666biological_processresponse to hypoxia
B0001701biological_processin utero embryonic development
B0005114molecular_functiontype II transforming growth factor beta receptor binding
B0005125molecular_functioncytokine activity
B0005160molecular_functiontransforming growth factor beta receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0007435biological_processsalivary gland morphogenesis
B0007507biological_processheart development
B0008083molecular_functiongrowth factor activity
B0008284biological_processpositive regulation of cell population proliferation
B0008285biological_processnegative regulation of cell population proliferation
B0010718biological_processpositive regulation of epithelial to mesenchymal transition
B0010936biological_processnegative regulation of macrophage cytokine production
B0030879biological_processmammary gland development
B0031012cellular_componentextracellular matrix
B0031093cellular_componentplatelet alpha granule lumen
B0032570biological_processresponse to progesterone
B0032967biological_processpositive regulation of collagen biosynthetic process
B0034713molecular_functiontype I transforming growth factor beta receptor binding
B0034714molecular_functiontype III transforming growth factor beta receptor binding
B0042127biological_processregulation of cell population proliferation
B0042476biological_processodontogenesis
B0042704biological_processuterine wall breakdown
B0042802molecular_functionidentical protein binding
B0043065biological_processpositive regulation of apoptotic process
B0043524biological_processnegative regulation of neuron apoptotic process
B0045216biological_processcell-cell junction organization
B0045597biological_processpositive regulation of cell differentiation
B0045893biological_processpositive regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048286biological_processlung alveolus development
B0050431molecular_functiontransforming growth factor beta binding
B0050714biological_processpositive regulation of protein secretion
B0051130biological_processpositive regulation of cellular component organization
B0051240biological_processpositive regulation of multicellular organismal process
B0051491biological_processpositive regulation of filopodium assembly
B0051496biological_processpositive regulation of stress fiber assembly
B0051781biological_processpositive regulation of cell division
B0060325biological_processface morphogenesis
B0060391biological_processpositive regulation of SMAD protein signal transduction
B0062009biological_processsecondary palate development
B0070483biological_processdetection of hypoxia
B0071363biological_processcellular response to growth factor stimulus
B0141091biological_processtransforming growth factor beta receptor superfamily signaling pathway
B1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
B1905005biological_processregulation of epithelial to mesenchymal transition involved in endocardial cushion formation
B1905075biological_processpositive regulation of tight junction disassembly
I0001818biological_processnegative regulation of cytokine production
I0005515molecular_functionprotein binding
I0005654cellular_componentnucleoplasm
I0005886cellular_componentplasma membrane
I0007179biological_processtransforming growth factor beta receptor signaling pathway
I0009986cellular_componentcell surface
I0010628biological_processpositive regulation of gene expression
I0016020cellular_componentmembrane
I0019838molecular_functiongrowth factor binding
I0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
I0035592biological_processestablishment of protein localization to extracellular region
I0038023molecular_functionsignaling receptor activity
I0046007biological_processnegative regulation of activated T cell proliferation
I0050431molecular_functiontransforming growth factor beta binding
I0062009biological_processsecondary palate development
I0141069molecular_functionreceptor ligand inhibitor activity
Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. VhePkgYyanfCsGpC
ChainResidueDetails
AVAL310-CYS325

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues607
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
IHIS20-ASN627
BGLN270

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
IASN203
IASN271
IASN345
IASN545
BASN112
BASN119

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
IASN308

237423

PDB entries from 2025-06-11

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