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8VS6

L-TGF-b3/avb8

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001568biological_processblood vessel development
A0001570biological_processvasculogenesis
A0001618molecular_functionvirus receptor activity
A0001846molecular_functionopsonin binding
A0001968molecular_functionfibronectin binding
A0002020molecular_functionprotease binding
A0005080molecular_functionprotein kinase C binding
A0005102molecular_functionsignaling receptor binding
A0005178molecular_functionintegrin binding
A0005245molecular_functionvoltage-gated calcium channel activity
A0005515molecular_functionprotein binding
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007229biological_processintegrin-mediated signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0008305cellular_componentintegrin complex
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010745biological_processnegative regulation of macrophage derived foam cell differentiation
A0010888biological_processnegative regulation of lipid storage
A0015026molecular_functioncoreceptor activity
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0017134molecular_functionfibroblast growth factor binding
A0019960molecular_functionC-X3-C chemokine binding
A0030335biological_processpositive regulation of cell migration
A0031258cellular_componentlamellipodium membrane
A0031527cellular_componentfilopodium membrane
A0031528cellular_componentmicrovillus membrane
A0031589biological_processcell-substrate adhesion
A0031994molecular_functioninsulin-like growth factor I binding
A0032369biological_processnegative regulation of lipid transport
A0032587cellular_componentruffle membrane
A0033627biological_processcell adhesion mediated by integrin
A0033690biological_processpositive regulation of osteoblast proliferation
A0034113biological_processheterotypic cell-cell adhesion
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0034682cellular_componentintegrin alphav-beta1 complex
A0034683cellular_componentintegrin alphav-beta3 complex
A0034684cellular_componentintegrin alphav-beta5 complex
A0034685cellular_componentintegrin alphav-beta6 complex
A0034686cellular_componentintegrin alphav-beta8 complex
A0035313biological_processwound healing, spreading of epidermal cells
A0035579cellular_componentspecific granule membrane
A0035866cellular_componentalphav-beta3 integrin-PKCalpha complex
A0035867cellular_componentalphav-beta3 integrin-IGF-1-IGF1R complex
A0035868cellular_componentalphav-beta3 integrin-HMGB1 complex
A0035987biological_processendodermal cell differentiation
A0038027biological_processapolipoprotein A-I-mediated signaling pathway
A0038132molecular_functionneuregulin binding
A0043277biological_processapoptotic cell clearance
A0045335cellular_componentphagocytic vesicle
A0045785biological_processpositive regulation of cell adhesion
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0050431molecular_functiontransforming growth factor beta binding
A0050748biological_processnegative regulation of lipoprotein metabolic process
A0050764biological_processregulation of phagocytosis
A0050840molecular_functionextracellular matrix binding
A0050919biological_processnegative chemotaxis
A0051057biological_processpositive regulation of small GTPase mediated signal transduction
A0070062cellular_componentextracellular exosome
A0070161cellular_componentanchoring junction
A0070371biological_processERK1 and ERK2 cascade
A0070588biological_processcalcium ion transmembrane transport
A0071604biological_processtransforming growth factor beta production
A0085017biological_processentry into host cell by a symbiont-containing vacuole
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0098609biological_processcell-cell adhesion
A1901388biological_processobsolete regulation of transforming growth factor beta activation
A1902533biological_processpositive regulation of intracellular signal transduction
A1905598biological_processnegative regulation of low-density lipoprotein receptor activity
A1990430molecular_functionextracellular matrix protein binding
A2000536biological_processnegative regulation of entry of bacterium into host cell
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
E0001666biological_processresponse to hypoxia
E0001701biological_processin utero embryonic development
E0005114molecular_functiontype II transforming growth factor beta receptor binding
E0005125molecular_functioncytokine activity
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005886cellular_componentplasma membrane
E0007179biological_processtransforming growth factor beta receptor signaling pathway
E0007435biological_processsalivary gland morphogenesis
E0007565biological_processfemale pregnancy
E0008083molecular_functiongrowth factor activity
E0008284biological_processpositive regulation of cell population proliferation
E0008285biological_processnegative regulation of cell population proliferation
E0009986cellular_componentcell surface
E0010718biological_processpositive regulation of epithelial to mesenchymal transition
E0010936biological_processnegative regulation of macrophage cytokine production
E0030141cellular_componentsecretory granule
E0030315cellular_componentT-tubule
E0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
E0030879biological_processmammary gland development
E0031093cellular_componentplatelet alpha granule lumen
E0032570biological_processresponse to progesterone
E0032967biological_processpositive regulation of collagen biosynthetic process
E0034616biological_processresponse to laminar fluid shear stress
E0034713molecular_functiontype I transforming growth factor beta receptor binding
E0034714molecular_functiontype III transforming growth factor beta receptor binding
E0042127biological_processregulation of cell population proliferation
E0042476biological_processodontogenesis
E0042704biological_processuterine wall breakdown
E0042802molecular_functionidentical protein binding
E0043025cellular_componentneuronal cell body
E0043065biological_processpositive regulation of apoptotic process
E0043231cellular_componentintracellular membrane-bounded organelle
E0043410biological_processpositive regulation of MAPK cascade
E0043524biological_processnegative regulation of neuron apoptotic process
E0043627biological_processresponse to estrogen
E0044877molecular_functionprotein-containing complex binding
E0045216biological_processcell-cell junction organization
E0045893biological_processpositive regulation of DNA-templated transcription
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0048286biological_processlung alveolus development
E0048565biological_processdigestive tract development
E0048702biological_processembryonic neurocranium morphogenesis
E0048839biological_processinner ear development
E0050431molecular_functiontransforming growth factor beta binding
E0050714biological_processpositive regulation of protein secretion
E0051491biological_processpositive regulation of filopodium assembly
E0051496biological_processpositive regulation of stress fiber assembly
E0051781biological_processpositive regulation of cell division
E0060325biological_processface morphogenesis
E0060364biological_processfrontal suture morphogenesis
E0060391biological_processpositive regulation of SMAD protein signal transduction
E0062009biological_processsecondary palate development
E0062023cellular_componentcollagen-containing extracellular matrix
E0070483biological_processdetection of hypoxia
E1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
E1905005biological_processregulation of epithelial to mesenchymal transition involved in endocardial cushion formation
E1905075biological_processpositive regulation of tight junction disassembly
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CqCfsGweGDrC
ChainResidueDetails
BCYS530-CYS541

site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. VnSKGQVCSGRG
ChainResidueDetails
BVAL552-GLY563

site_idPS00243
Number of Residues14
DetailsINTEGRIN_BETA Integrins beta chain cysteine-rich domain signature. CsGr..GvCvCgkCsC
ChainResidueDetails
BCYS478-CYS491
BCYS559-CYS572

site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. VhePkgYyanfCsGpC
ChainResidueDetails
EVAL313-CYS328

site_idPS01186
Number of Residues14
DetailsEGF_2 EGF-like domain signature 2. CqCfsGWegdrcq..C
ChainResidueDetails
BCYS530-CYS543

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues641
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BGLU1-ARG642

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: in MIDAS binding site => ECO:0000269|PubMed:31792290, ECO:0007744|PDB:6OM1, ECO:0007744|PDB:6OM2
ChainResidueDetails
BASP112
AASP292
AASP349
AASP351
AASP353
APHE355
AASP357
AASP413
AASP415
AASN417
ATYR419
BGLU212
AASP421
AASP234
AILE236
AASP238
AASP284
AASN286
AASP288
ATYR290

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: in MIDAS binding site => ECO:0000269|PubMed:31792290, ECO:0007744|PDB:6OM2
ChainResidueDetails
BSER114

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: in LIMBS binding site => ECO:0000269|PubMed:31792290, ECO:0007744|PDB:6OM1, ECO:0007744|PDB:6OM2
ChainResidueDetails
BASP151
BASN207
BASP209
BPRO211

site_idSWS_FT_FI5
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN191
BASN414
BASN424
BASN606

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31792290, ECO:0007744|PDB:6OM1
ChainResidueDetails
BASN360
BASN379

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31792290, ECO:0007744|PDB:6OM1, ECO:0007744|PDB:6OM2
ChainResidueDetails
BASN389
AASN982
AASN989

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN860
AASN954

site_idSWS_FT_FI9
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
ChainResidueDetails
AASN883

227344

PDB entries from 2024-11-13

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