8VS6
L-TGF-b3/avb8
Functional Information from PROSITE/UniProt
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. CqCfsGweGDrC |
| Chain | Residue | Details |
| B | CYS530-CYS541 |
| site_id | PS00070 |
| Number of Residues | 12 |
| Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. VnSKGQVCSGRG |
| Chain | Residue | Details |
| B | VAL552-GLY563 |
| site_id | PS00243 |
| Number of Residues | 14 |
| Details | INTEGRIN_BETA Integrins beta chain cysteine-rich domain signature. CsGr..GvCvCgkCsC |
| Chain | Residue | Details |
| B | CYS478-CYS491 | |
| B | CYS559-CYS572 |
| site_id | PS00250 |
| Number of Residues | 16 |
| Details | TGF_BETA_1 TGF-beta family signature. VhePkgYyanfCsGpC |
| Chain | Residue | Details |
| E | VAL313-CYS328 |
| site_id | PS01186 |
| Number of Residues | 14 |
| Details | EGF_2 EGF-like domain signature 2. CqCfsGWegdrcq..C |
| Chain | Residue | Details |
| B | CYS530-CYS543 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 641 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | GLU1-ARG642 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:31792290, ECO:0007744|PDB:6OM1, ECO:0007744|PDB:6OM2 |
| Chain | Residue | Details |
| B | ASP112 | |
| A | ASP292 | |
| A | ASP349 | |
| A | ASP351 | |
| A | ASP353 | |
| A | PHE355 | |
| A | ASP357 | |
| A | ASP413 | |
| A | ASP415 | |
| A | ASN417 | |
| A | TYR419 | |
| B | GLU212 | |
| A | ASP421 | |
| A | ASP234 | |
| A | ILE236 | |
| A | ASP238 | |
| A | ASP284 | |
| A | ASN286 | |
| A | ASP288 | |
| A | TYR290 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:31792290, ECO:0007744|PDB:6OM2 |
| Chain | Residue | Details |
| B | SER114 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: in LIMBS binding site => ECO:0000269|PubMed:31792290, ECO:0007744|PDB:6OM1, ECO:0007744|PDB:6OM2 |
| Chain | Residue | Details |
| B | ASP151 | |
| B | ASN207 | |
| B | ASP209 | |
| B | PRO211 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN191 | |
| B | ASN414 | |
| B | ASN424 | |
| B | ASN606 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31792290, ECO:0007744|PDB:6OM1 |
| Chain | Residue | Details |
| B | ASN360 | |
| B | ASN379 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31792290, ECO:0007744|PDB:6OM1, ECO:0007744|PDB:6OM2 |
| Chain | Residue | Details |
| B | ASN389 | |
| A | ASN982 | |
| A | ASN989 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN860 | |
| A | ASN954 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| A | ASN883 |
