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8VML

PRC2_AJ1-450 bound to H3K4me3

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0001222molecular_functiontranscription corepressor binding
A0001739cellular_componentsex chromatin
A0003682molecular_functionchromatin binding
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005677cellular_componentchromatin silencing complex
A0005730cellular_componentnucleolus
A0006325biological_processchromatin organization
A0008047molecular_functionenzyme activator activity
A0008270molecular_functionzinc ion binding
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0016586cellular_componentRSC-type complex
A0016604cellular_componentnuclear body
A0031490molecular_functionchromatin DNA binding
A0032993cellular_componentprotein-DNA complex
A0035098cellular_componentESC/E(Z) complex
A0043565molecular_functionsequence-specific DNA binding
A0045596biological_processnegative regulation of cell differentiation
A0046872molecular_functionmetal ion binding
A0048709biological_processoligodendrocyte differentiation
A0060816biological_processrandom inactivation of X chromosome
A0062072molecular_functionhistone H3K9me2/3 reader activity
A0106222molecular_functionlncRNA binding
A0140718biological_processfacultative heterochromatin formation
A1990841molecular_functionpromoter-specific chromatin binding
A1990904cellular_componentribonucleoprotein complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000785cellular_componentchromatin
B0001889biological_processliver development
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005739cellular_componentmitochondrion
B0006325biological_processchromatin organization
B0006338biological_processchromatin remodeling
B0007417biological_processcentral nervous system development
B0008283biological_processcell population proliferation
B0010468biological_processregulation of gene expression
B0030154biological_processcell differentiation
B0032452molecular_functionhistone demethylase activity
B0035097cellular_componenthistone methyltransferase complex
B0035098cellular_componentESC/E(Z) complex
B0042127biological_processregulation of cell population proliferation
B0043130molecular_functionubiquitin binding
B0045892biological_processnegative regulation of DNA-templated transcription
B0046976molecular_functionhistone H3K27 methyltransferase activity
B0048536biological_processspleen development
B0048538biological_processthymus development
B0048731biological_processsystem development
B0048863biological_processstem cell differentiation
B0060038biological_processcardiac muscle cell proliferation
B0060044biological_processnegative regulation of cardiac muscle cell proliferation
B0060816biological_processrandom inactivation of X chromosome
B0061649molecular_functionubiquitin-modified histone reader activity
B0140718biological_processfacultative heterochromatin formation
B1902682biological_processprotein localization to pericentric heterochromatin
B1990830biological_processcellular response to leukemia inhibitory factor
C0000082biological_processG1/S transition of mitotic cell cycle
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000781cellular_componentchromosome, telomeric region
C0000785cellular_componentchromatin
C0000976molecular_functiontranscription cis-regulatory region binding
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
C0001222molecular_functiontranscription corepressor binding
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003714molecular_functiontranscription corepressor activity
C0003723molecular_functionRNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005677cellular_componentchromatin silencing complex
C0005694cellular_componentchromosome
C0005721cellular_componentpericentric heterochromatin
C0006325biological_processchromatin organization
C0006338biological_processchromatin remodeling
C0006346biological_processDNA methylation-dependent constitutive heterochromatin formation
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0008168molecular_functionmethyltransferase activity
C0008284biological_processpositive regulation of cell population proliferation
C0009913biological_processepidermal cell differentiation
C0010468biological_processregulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010718biological_processpositive regulation of epithelial to mesenchymal transition
C0014013biological_processregulation of gliogenesis
C0014834biological_processskeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
C0014898biological_processcardiac muscle hypertrophy in response to stress
C0016279molecular_functionprotein-lysine N-methyltransferase activity
C0016740molecular_functiontransferase activity
C0021695biological_processcerebellar cortex development
C0021766biological_processhippocampus development
C0030097biological_processhemopoiesis
C0030183biological_processB cell differentiation
C0030216biological_processkeratinocyte differentiation
C0030335biological_processpositive regulation of cell migration
C0031048biological_processregulatory ncRNA-mediated heterochromatin formation
C0031490molecular_functionchromatin DNA binding
C0031491molecular_functionnucleosome binding
C0031507biological_processheterochromatin formation
C0031509biological_processsubtelomeric heterochromatin formation
C0032259biological_processmethylation
C0032355biological_processresponse to estradiol
C0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
C0035098cellular_componentESC/E(Z) complex
C0035984biological_processcellular response to trichostatin A
C0036211biological_processprotein modification process
C0036333biological_processhepatocyte homeostasis
C0042054molecular_functionhistone methyltransferase activity
C0042127biological_processregulation of cell population proliferation
C0042393molecular_functionhistone binding
C0042752biological_processregulation of circadian rhythm
C0043021molecular_functionribonucleoprotein complex binding
C0043406biological_processpositive regulation of MAP kinase activity
C0043547biological_processpositive regulation of GTPase activity
C0043565molecular_functionsequence-specific DNA binding
C0045120cellular_componentpronucleus
C0045202cellular_componentsynapse
C0045605biological_processnegative regulation of epidermal cell differentiation
C0045617biological_processnegative regulation of keratinocyte differentiation
C0045814biological_processnegative regulation of gene expression, epigenetic
C0045892biological_processnegative regulation of DNA-templated transcription
C0046976molecular_functionhistone H3K27 methyltransferase activity
C0048387biological_processnegative regulation of retinoic acid receptor signaling pathway
C0048511biological_processrhythmic process
C0048863biological_processstem cell differentiation
C0050767biological_processregulation of neurogenesis
C0051154biological_processnegative regulation of striated muscle cell differentiation
C0051932biological_processsynaptic transmission, GABAergic
C0070301biological_processcellular response to hydrogen peroxide
C0070314biological_processG1 to G0 transition
C0070878molecular_functionprimary miRNA binding
C0071168biological_processprotein localization to chromatin
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0090183biological_processregulation of kidney development
C0097421biological_processliver regeneration
C0106222molecular_functionlncRNA binding
C0140718biological_processfacultative heterochromatin formation
C0140938molecular_functionhistone H3 methyltransferase activity
C0140951molecular_functionhistone H3K27 trimethyltransferase activity
C1900006biological_processpositive regulation of dendrite development
C1900016biological_processnegative regulation of cytokine production involved in inflammatory response
C1902808biological_processpositive regulation of cell cycle G1/S phase transition
C1904772biological_processresponse to tetrachloromethane
C1990841molecular_functionpromoter-specific chromatin binding
C2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
C2000737biological_processnegative regulation of stem cell differentiation
L0000122biological_processnegative regulation of transcription by RNA polymerase II
L0001222molecular_functiontranscription corepressor binding
L0001739cellular_componentsex chromatin
L0003682molecular_functionchromatin binding
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005677cellular_componentchromatin silencing complex
L0005694cellular_componentchromosome
L0005829cellular_componentcytosol
L0006325biological_processchromatin organization
L0008047molecular_functionenzyme activator activity
L0021510biological_processspinal cord development
L0031491molecular_functionnucleosome binding
L0031507biological_processheterochromatin formation
L0035064molecular_functionmethylated histone binding
L0035098cellular_componentESC/E(Z) complex
L0042802molecular_functionidentical protein binding
L0045120cellular_componentpronucleus
L0045892biological_processnegative regulation of DNA-templated transcription
L0048709biological_processoligodendrocyte differentiation
L0071514biological_processgenomic imprinting
L0140718biological_processfacultative heterochromatin formation
L1990830biological_processcellular response to leukemia inhibitory factor
L2000011biological_processregulation of adaxial/abaxial pattern formation
N0000118cellular_componenthistone deacetylase complex
N0000122biological_processnegative regulation of transcription by RNA polymerase II
N0000781cellular_componentchromosome, telomeric region
N0000785cellular_componentchromatin
N0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005694cellular_componentchromosome
N0005829cellular_componentcytosol
N0006260biological_processDNA replication
N0006281biological_processDNA repair
N0006325biological_processchromatin organization
N0006334biological_processnucleosome assembly
N0006335biological_processDNA replication-dependent chromatin assembly
N0006338biological_processchromatin remodeling
N0006355biological_processregulation of DNA-templated transcription
N0006974biological_processDNA damage response
N0007420biological_processbrain development
N0008094molecular_functionATP-dependent activity, acting on DNA
N0008285biological_processnegative regulation of cell population proliferation
N0016581cellular_componentNuRD complex
N0016589cellular_componentNURF complex
N0030336biological_processnegative regulation of cell migration
N0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
N0031492molecular_functionnucleosomal DNA binding
N0032991cellular_componentprotein-containing complex
N0033186cellular_componentCAF-1 complex
N0035098cellular_componentESC/E(Z) complex
N0042393molecular_functionhistone binding
N0042659biological_processregulation of cell fate specification
N0042826molecular_functionhistone deacetylase binding
N0045892biological_processnegative regulation of DNA-templated transcription
N0045893biological_processpositive regulation of DNA-templated transcription
N0070822cellular_componentSin3-type complex
N1902455biological_processnegative regulation of stem cell population maintenance
N1902459biological_processpositive regulation of stem cell population maintenance
N1904949cellular_componentATPase complex
N2000736biological_processregulation of stem cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues22
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cpw..CtlnCrklysllkHlklc.H
ChainResidueDetails
ACYS450-HIS471
PCYS55-HIS78
PCYS122-HIS144

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI
ChainResidueDetails
LLEU206-ILE220
NLEU193-ILE207
NLEU289-LEU303
NLEU333-LEU347

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues25
DetailsZN_FING: C2H2-type 1 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
PTYR53-HIS78

site_idSWS_FT_FI2
Number of Residues22
DetailsZN_FING: C2H2-type 2; degenerate => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
PLYS92-HIS114
CSER363

site_idSWS_FT_FI3
Number of Residues24
DetailsZN_FING: C2H2-type 3 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
PPHE120-HIS144
ASER541
ASER726

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:22814378
ChainResidueDetails
PTYR10
LLYS197
LLYS268
LLYS284

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231
ChainResidueDetails
PSER26
PARG32

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
PASN149
ALYS73

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
PLEU214
NLYS160
ALYS390

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
PHIS218
PSER219

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
PSER182

236620

PDB entries from 2025-05-28

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