8VMJ
H3K4me3 nucleosome bound to PRC2_AJ119-450
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| I | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| I | 0000785 | cellular_component | chromatin |
| I | 0000786 | cellular_component | nucleosome |
| I | 0003677 | molecular_function | DNA binding |
| I | 0003682 | molecular_function | chromatin binding |
| I | 0005515 | molecular_function | protein binding |
| I | 0005576 | cellular_component | extracellular region |
| I | 0005634 | cellular_component | nucleus |
| I | 0005654 | cellular_component | nucleoplasm |
| I | 0005694 | cellular_component | chromosome |
| I | 0006325 | biological_process | chromatin organization |
| I | 0006334 | biological_process | nucleosome assembly |
| I | 0010467 | biological_process | gene expression |
| I | 0030527 | molecular_function | structural constituent of chromatin |
| I | 0046982 | molecular_function | protein heterodimerization activity |
| I | 0070062 | cellular_component | extracellular exosome |
| J | 0000781 | cellular_component | chromosome, telomeric region |
| J | 0000786 | cellular_component | nucleosome |
| J | 0003677 | molecular_function | DNA binding |
| J | 0003723 | molecular_function | RNA binding |
| J | 0005515 | molecular_function | protein binding |
| J | 0005576 | cellular_component | extracellular region |
| J | 0005634 | cellular_component | nucleus |
| J | 0005654 | cellular_component | nucleoplasm |
| J | 0005694 | cellular_component | chromosome |
| J | 0006325 | biological_process | chromatin organization |
| J | 0006334 | biological_process | nucleosome assembly |
| J | 0016020 | cellular_component | membrane |
| J | 0030527 | molecular_function | structural constituent of chromatin |
| J | 0032200 | biological_process | telomere organization |
| J | 0032991 | cellular_component | protein-containing complex |
| J | 0043505 | cellular_component | CENP-A containing nucleosome |
| J | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
| J | 0046982 | molecular_function | protein heterodimerization activity |
| J | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
| J | 0070062 | cellular_component | extracellular exosome |
| K | 0000786 | cellular_component | nucleosome |
| K | 0003677 | molecular_function | DNA binding |
| K | 0030527 | molecular_function | structural constituent of chromatin |
| K | 0046982 | molecular_function | protein heterodimerization activity |
| M | 0000786 | cellular_component | nucleosome |
| M | 0003677 | molecular_function | DNA binding |
| M | 0030527 | molecular_function | structural constituent of chromatin |
| M | 0046982 | molecular_function | protein heterodimerization activity |
| O | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| O | 0000785 | cellular_component | chromatin |
| O | 0000786 | cellular_component | nucleosome |
| O | 0003677 | molecular_function | DNA binding |
| O | 0003682 | molecular_function | chromatin binding |
| O | 0005515 | molecular_function | protein binding |
| O | 0005576 | cellular_component | extracellular region |
| O | 0005634 | cellular_component | nucleus |
| O | 0005654 | cellular_component | nucleoplasm |
| O | 0005694 | cellular_component | chromosome |
| O | 0006325 | biological_process | chromatin organization |
| O | 0006334 | biological_process | nucleosome assembly |
| O | 0010467 | biological_process | gene expression |
| O | 0030527 | molecular_function | structural constituent of chromatin |
| O | 0046982 | molecular_function | protein heterodimerization activity |
| O | 0070062 | cellular_component | extracellular exosome |
| Q | 0000781 | cellular_component | chromosome, telomeric region |
| Q | 0000786 | cellular_component | nucleosome |
| Q | 0003677 | molecular_function | DNA binding |
| Q | 0003723 | molecular_function | RNA binding |
| Q | 0005515 | molecular_function | protein binding |
| Q | 0005576 | cellular_component | extracellular region |
| Q | 0005634 | cellular_component | nucleus |
| Q | 0005654 | cellular_component | nucleoplasm |
| Q | 0005694 | cellular_component | chromosome |
| Q | 0006325 | biological_process | chromatin organization |
| Q | 0006334 | biological_process | nucleosome assembly |
| Q | 0016020 | cellular_component | membrane |
| Q | 0030527 | molecular_function | structural constituent of chromatin |
| Q | 0032200 | biological_process | telomere organization |
| Q | 0032991 | cellular_component | protein-containing complex |
| Q | 0043505 | cellular_component | CENP-A containing nucleosome |
| Q | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
| Q | 0046982 | molecular_function | protein heterodimerization activity |
| Q | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
| Q | 0070062 | cellular_component | extracellular exosome |
| R | 0000786 | cellular_component | nucleosome |
| R | 0003677 | molecular_function | DNA binding |
| R | 0030527 | molecular_function | structural constituent of chromatin |
| R | 0046982 | molecular_function | protein heterodimerization activity |
| S | 0000786 | cellular_component | nucleosome |
| S | 0003677 | molecular_function | DNA binding |
| S | 0030527 | molecular_function | structural constituent of chromatin |
| S | 0046982 | molecular_function | protein heterodimerization activity |
Functional Information from PROSITE/UniProt
| site_id | PS00046 |
| Number of Residues | 7 |
| Details | HISTONE_H2A Histone H2A signature. AGLqFPV |
| Chain | Residue | Details |
| K | ALA21-VAL27 |
| site_id | PS00047 |
| Number of Residues | 5 |
| Details | HISTONE_H4 Histone H4 signature. GAKRH |
| Chain | Residue | Details |
| J | GLY14-HIS18 |
| site_id | PS00322 |
| Number of Residues | 7 |
| Details | HISTONE_H3_1 Histone H3 signature 1. KAPRKQL |
| Chain | Residue | Details |
| I | LYS14-LEU20 |
| site_id | PS00357 |
| Number of Residues | 23 |
| Details | HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG |
| Chain | Residue | Details |
| M | ARG89-GLY111 |
| site_id | PS00959 |
| Number of Residues | 9 |
| Details | HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI |
| Chain | Residue | Details |
| I | PRO66-ILE74 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | DNA_BIND: |
| Chain | Residue | Details |
| J | LYS16-LYS20 | |
| Q | LYS16-LYS20 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:17967882 |
| Chain | Residue | Details |
| J | SER1 | |
| Q | SER1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate => ECO:0000250|UniProtKB:P62806 |
| Chain | Residue | Details |
| J | ARG3 | |
| Q | ARG3 | |
| I | LYS64 | |
| O | M3L4 | |
| O | LYS18 | |
| O | LYS64 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-lactoyllysine; alternate => ECO:0000269|PubMed:31645732 |
| Chain | Residue | Details |
| J | LYS5 | |
| Q | LYS5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393 |
| Chain | Residue | Details |
| J | LYS8 | |
| J | LYS16 | |
| J | LYS44 | |
| Q | LYS8 | |
| Q | LYS16 | |
| Q | LYS44 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| J | LYS12 | |
| J | LYS31 | |
| J | LYS77 | |
| J | LYS91 | |
| Q | LYS12 | |
| Q | LYS31 | |
| Q | LYS77 | |
| Q | LYS91 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:17967882, ECO:0000269|PubMed:27338793 |
| Chain | Residue | Details |
| J | LYS20 | |
| Q | LYS20 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PAK2 => ECO:0000269|PubMed:21724829, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| J | SER47 | |
| Q | SER47 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| J | TYR51 | |
| Q | TYR51 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297 |
| Chain | Residue | Details |
| J | LYS59 | |
| Q | LYS59 | |
| O | LYS14 | |
| O | LYS56 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62806 |
| Chain | Residue | Details |
| J | LYS79 | |
| Q | LYS79 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62806 |
| Chain | Residue | Details |
| J | THR80 | |
| Q | THR80 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| J | TYR88 | |
| Q | TYR88 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447 |
| Chain | Residue | Details |
| J | LYS12 | |
| Q | LYS12 | |
| O | LYS27 | |
| O | LYS36 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:19818714 |
| Chain | Residue | Details |
| I | SER28 | |
| J | LYS91 | |
| Q | LYS91 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| J | LYS20 | |
| J | LYS59 | |
| J | LYS79 | |
| Q | LYS20 | |
| Q | LYS59 | |
| Q | LYS79 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000269|PubMed:30886146 |
| Chain | Residue | Details |
| J | LYS31 | |
| Q | LYS31 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:20850016 |
| Chain | Residue | Details |
| I | SER57 | |
| O | SER57 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:29211711 |
| Chain | Residue | Details |
| I | LYS79 | |
| O | LYS79 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:20850016 |
| Chain | Residue | Details |
| I | THR80 | |
| O | THR80 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243 |
| Chain | Residue | Details |
| I | SER86 | |
| O | SER86 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| I | THR107 | |
| O | THR107 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297 |
| Chain | Residue | Details |
| I | LYS115 | |
| O | LYS115 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:27436229 |
| Chain | Residue | Details |
| I | LYS122 | |
| O | LYS122 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 2 |
| Details | LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806 |
| Chain | Residue | Details |
| I | LYS18 | |
| O | LYS18 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:21076176 |
| Chain | Residue | Details |
| I | CYS110 | |
| O | CYS110 |
