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8VM6

Composite structure of human FASN with NADPH in State 8

Functional Information from GO Data
ChainGOidnamespacecontents
A0001649biological_processosteoblast differentiation
A0002064biological_processepithelial cell development
A0003723molecular_functionRNA binding
A0003824molecular_functioncatalytic activity
A0004312molecular_functionfatty acid synthase activity
A0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
A0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
A0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
A0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006084biological_processacetyl-CoA metabolic process
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0006954biological_processinflammatory response
A0007584biological_processresponse to nutrient
A0008610biological_processlipid biosynthetic process
A0008611biological_processether lipid biosynthetic process
A0009888biological_processtissue development
A0016020cellular_componentmembrane
A0016297molecular_functionfatty acyl-[ACP] hydrolase activity
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0016787molecular_functionhydrolase activity
A0016829molecular_functionlyase activity
A0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
A0030223biological_processneutrophil differentiation
A0030224biological_processmonocyte differentiation
A0030879biological_processmammary gland development
A0031667biological_processresponse to nutrient levels
A0042470cellular_componentmelanosome
A0042587cellular_componentglycogen granule
A0042802molecular_functionidentical protein binding
A0044788biological_processmodulation by host of viral process
A0045296molecular_functioncadherin binding
A0046949biological_processfatty-acyl-CoA biosynthetic process
A0061771biological_processresponse to caloric restriction
A0070062cellular_componentextracellular exosome
A0071353biological_processcellular response to interleukin-4
A0090557biological_processestablishment of endothelial intestinal barrier
A0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
B0001649biological_processosteoblast differentiation
B0002064biological_processepithelial cell development
B0003723molecular_functionRNA binding
B0003824molecular_functioncatalytic activity
B0004312molecular_functionfatty acid synthase activity
B0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
B0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
B0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
B0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006084biological_processacetyl-CoA metabolic process
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0006954biological_processinflammatory response
B0007584biological_processresponse to nutrient
B0008610biological_processlipid biosynthetic process
B0008611biological_processether lipid biosynthetic process
B0009888biological_processtissue development
B0016020cellular_componentmembrane
B0016297molecular_functionfatty acyl-[ACP] hydrolase activity
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0016787molecular_functionhydrolase activity
B0016829molecular_functionlyase activity
B0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B0030223biological_processneutrophil differentiation
B0030224biological_processmonocyte differentiation
B0030879biological_processmammary gland development
B0031667biological_processresponse to nutrient levels
B0042470cellular_componentmelanosome
B0042587cellular_componentglycogen granule
B0042802molecular_functionidentical protein binding
B0044788biological_processmodulation by host of viral process
B0045296molecular_functioncadherin binding
B0046949biological_processfatty-acyl-CoA biosynthetic process
B0061771biological_processresponse to caloric restriction
B0070062cellular_componentextracellular exosome
B0071353biological_processcellular response to interleukin-4
B0090557biological_processestablishment of endothelial intestinal barrier
B0141148molecular_functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLMSVEVRQTL
ChainResidueDetails
AASP2151-LEU2166

site_idPS00606
Number of Residues17
DetailsKS3_1 Ketosynthase family 3 (KS3) active site signature. GPSiaLDtACSSSlmAL
ChainResidueDetails
AGLY152-LEU168

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348
ChainResidueDetails
ACYS161
AHIS293
AHIS331
BCYS161
BHIS293
BHIS331

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: For malonyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU10022
ChainResidueDetails
ASER581
BSER581

site_idSWS_FT_FI3
Number of Residues2
DetailsACT_SITE: Proton acceptor; for dehydratase activity => ECO:0000255|PROSITE-ProRule:PRU01363
ChainResidueDetails
AHIS878
BHIS878

site_idSWS_FT_FI4
Number of Residues2
DetailsACT_SITE: Proton donor; for dehydratase activity => ECO:0000255|PROSITE-ProRule:PRU01363
ChainResidueDetails
AASP1031
BASP1031

site_idSWS_FT_FI5
Number of Residues2
DetailsACT_SITE: For thioesterase activity => ECO:0000255|PROSITE-ProRule:PRU10022, ECO:0000269|PubMed:17618296
ChainResidueDetails
ASER2308
BSER2308

site_idSWS_FT_FI6
Number of Residues2
DetailsACT_SITE: For thioesterase activity => ECO:0000255|PROSITE-ProRule:PRU10022
ChainResidueDetails
AHIS2481
BHIS2481

site_idSWS_FT_FI7
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P19096
ChainResidueDetails
AASP647
APHE671
AARG773
BASP647
BPHE671
BARG773

site_idSWS_FT_FI8
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ALEU1671
ASER1886
BLEU1671
BSER1886

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER63
ASER1584
BSER63
BSER1584

site_idSWS_FT_FI10
Number of Residues16
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS70
BLYS298
BLYS436
BLYS528
BLYS673
BLYS1771
BLYS1847
BLYS1995
ALYS298
ALYS436
ALYS528
ALYS673
ALYS1771
ALYS1847
ALYS1995
BLYS70

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER207
BSER207

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P19096
ChainResidueDetails
ASER725
ASER1594
BSER725
BSER1594

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P19096
ChainResidueDetails
ALYS992
ALYS2391
BLYS992
BLYS2391

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER1174
BSER1174

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER1411
BSER1411

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:26851298
ChainResidueDetails
ACYS1471
ACYS2091
BCYS1471
BCYS2091

site_idSWS_FT_FI17
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS1704
BLYS1704

site_idSWS_FT_FI18
Number of Residues2
DetailsMOD_RES: Phosphoserine; alternate => ECO:0000250|UniProtKB:P12785
ChainResidueDetails
ASER2156
BSER2156

site_idSWS_FT_FI19
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER2198
BSER2198

site_idSWS_FT_FI20
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR2204
BTHR2204

site_idSWS_FT_FI21
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR2215
BTHR2215

site_idSWS_FT_FI22
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER2236
BSER2236

site_idSWS_FT_FI23
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211
ChainResidueDetails
ALYS2449
BLYS2449

237735

PDB entries from 2025-06-18

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