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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8VM4

CryoEM structure of human S-OPA1 assembled on lipid membrane containing brominated cardiolipin in membrane-adjacent state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000266biological_processmitochondrial fission
A0000287molecular_functionmagnesium ion binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005743cellular_componentmitochondrial inner membrane
A0005758cellular_componentmitochondrial intermembrane space
A0005874cellular_componentmicrotubule
A0006915biological_processapoptotic process
A0007005biological_processmitochondrion organization
A0007007biological_processinner mitochondrial membrane organization
A0007601biological_processvisual perception
A0008017molecular_functionmicrotubule binding
A0008053biological_processmitochondrial fusion
A0008289molecular_functionlipid binding
A0010821biological_processregulation of mitochondrion organization
A0016020cellular_componentmembrane
A0016559biological_processperoxisome fission
A0016787molecular_functionhydrolase activity
A0019896biological_processaxonal transport of mitochondrion
A0030061cellular_componentmitochondrial crista
A0030425cellular_componentdendrite
A0031966cellular_componentmitochondrial membrane
A0032740biological_processpositive regulation of interleukin-17 production
A0042407biological_processcristae formation
A0043066biological_processnegative regulation of apoptotic process
A0046039biological_processGTP metabolic process
A0051259biological_processprotein complex oligomerization
A0061025biological_processmembrane fusion
A0070300molecular_functionphosphatidic acid binding
A0090201biological_processnegative regulation of release of cytochrome c from mitochondria
A0090398biological_processcellular senescence
A0097749biological_processmembrane tubulation
A0140523molecular_functionGTPase-dependent fusogenic activity
A0180020molecular_functionmembrane bending activity
A1901612molecular_functioncardiolipin binding
A1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A1904115cellular_componentaxon cytoplasm
A1990627biological_processmitochondrial inner membrane fusion
A2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
A2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
B0000166molecular_functionnucleotide binding
B0000266biological_processmitochondrial fission
B0000287molecular_functionmagnesium ion binding
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005743cellular_componentmitochondrial inner membrane
B0005758cellular_componentmitochondrial intermembrane space
B0005874cellular_componentmicrotubule
B0006915biological_processapoptotic process
B0007005biological_processmitochondrion organization
B0007007biological_processinner mitochondrial membrane organization
B0007601biological_processvisual perception
B0008017molecular_functionmicrotubule binding
B0008053biological_processmitochondrial fusion
B0008289molecular_functionlipid binding
B0010821biological_processregulation of mitochondrion organization
B0016020cellular_componentmembrane
B0016559biological_processperoxisome fission
B0016787molecular_functionhydrolase activity
B0019896biological_processaxonal transport of mitochondrion
B0030061cellular_componentmitochondrial crista
B0030425cellular_componentdendrite
B0031966cellular_componentmitochondrial membrane
B0032740biological_processpositive regulation of interleukin-17 production
B0042407biological_processcristae formation
B0043066biological_processnegative regulation of apoptotic process
B0046039biological_processGTP metabolic process
B0051259biological_processprotein complex oligomerization
B0061025biological_processmembrane fusion
B0070300molecular_functionphosphatidic acid binding
B0090201biological_processnegative regulation of release of cytochrome c from mitochondria
B0090398biological_processcellular senescence
B0097749biological_processmembrane tubulation
B0140523molecular_functionGTPase-dependent fusogenic activity
B0180020molecular_functionmembrane bending activity
B1901612molecular_functioncardiolipin binding
B1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
B1904115cellular_componentaxon cytoplasm
B1990627biological_processmitochondrial inner membrane fusion
B2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
B2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
C0000166molecular_functionnucleotide binding
C0000266biological_processmitochondrial fission
C0000287molecular_functionmagnesium ion binding
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005741cellular_componentmitochondrial outer membrane
C0005743cellular_componentmitochondrial inner membrane
C0005758cellular_componentmitochondrial intermembrane space
C0005874cellular_componentmicrotubule
C0006915biological_processapoptotic process
C0007005biological_processmitochondrion organization
C0007007biological_processinner mitochondrial membrane organization
C0007601biological_processvisual perception
C0008017molecular_functionmicrotubule binding
C0008053biological_processmitochondrial fusion
C0008289molecular_functionlipid binding
C0010821biological_processregulation of mitochondrion organization
C0016020cellular_componentmembrane
C0016559biological_processperoxisome fission
C0016787molecular_functionhydrolase activity
C0019896biological_processaxonal transport of mitochondrion
C0030061cellular_componentmitochondrial crista
C0030425cellular_componentdendrite
C0031966cellular_componentmitochondrial membrane
C0032740biological_processpositive regulation of interleukin-17 production
C0042407biological_processcristae formation
C0043066biological_processnegative regulation of apoptotic process
C0046039biological_processGTP metabolic process
C0051259biological_processprotein complex oligomerization
C0061025biological_processmembrane fusion
C0070300molecular_functionphosphatidic acid binding
C0090201biological_processnegative regulation of release of cytochrome c from mitochondria
C0090398biological_processcellular senescence
C0097749biological_processmembrane tubulation
C0140523molecular_functionGTPase-dependent fusogenic activity
C0180020molecular_functionmembrane bending activity
C1901612molecular_functioncardiolipin binding
C1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
C1904115cellular_componentaxon cytoplasm
C1990627biological_processmitochondrial inner membrane fusion
C2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
C2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
D0000166molecular_functionnucleotide binding
D0000266biological_processmitochondrial fission
D0000287molecular_functionmagnesium ion binding
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005741cellular_componentmitochondrial outer membrane
D0005743cellular_componentmitochondrial inner membrane
D0005758cellular_componentmitochondrial intermembrane space
D0005874cellular_componentmicrotubule
D0006915biological_processapoptotic process
D0007005biological_processmitochondrion organization
D0007007biological_processinner mitochondrial membrane organization
D0007601biological_processvisual perception
D0008017molecular_functionmicrotubule binding
D0008053biological_processmitochondrial fusion
D0008289molecular_functionlipid binding
D0010821biological_processregulation of mitochondrion organization
D0016020cellular_componentmembrane
D0016559biological_processperoxisome fission
D0016787molecular_functionhydrolase activity
D0019896biological_processaxonal transport of mitochondrion
D0030061cellular_componentmitochondrial crista
D0030425cellular_componentdendrite
D0031966cellular_componentmitochondrial membrane
D0032740biological_processpositive regulation of interleukin-17 production
D0042407biological_processcristae formation
D0043066biological_processnegative regulation of apoptotic process
D0046039biological_processGTP metabolic process
D0051259biological_processprotein complex oligomerization
D0061025biological_processmembrane fusion
D0070300molecular_functionphosphatidic acid binding
D0090201biological_processnegative regulation of release of cytochrome c from mitochondria
D0090398biological_processcellular senescence
D0097749biological_processmembrane tubulation
D0140523molecular_functionGTPase-dependent fusogenic activity
D0180020molecular_functionmembrane bending activity
D1901612molecular_functioncardiolipin binding
D1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
D1904115cellular_componentaxon cytoplasm
D1990627biological_processmitochondrial inner membrane fusion
D2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
D2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsIntramembrane: {"evidences":[{"source":"PubMed","id":"37612504","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37612506","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues712
DetailsTopological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"37612504","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37612506","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1104
DetailsDomain: {"description":"Dynamin-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues28
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues12
DetailsRegion: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues12
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues12
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1204
DetailsRegion: {"description":"Stalk region","evidences":[{"source":"PubMed","id":"37612504","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37612506","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues480
DetailsRegion: {"description":"Paddle region","evidences":[{"source":"PubMed","id":"37612504","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37612506","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues260
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32379273","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6JTG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32379273","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37612506","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6JTG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8EEW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"37612506","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EEW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2025-12-10

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