8VLY
Cryo-EM structure of human HGSNAT in transition state
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 584 |
| Details | TOPO_DOM: Lumenal, vesicle => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-SER190 | |
| B | GLY442-GLY500 | |
| B | LYS551-ASN564 | |
| B | HIS614-LYS634 | |
| A | HIS297-GLY302 | |
| A | SER367-PRO374 | |
| A | GLY442-GLY500 | |
| A | LYS551-ASN564 | |
| A | HIS614-LYS634 | |
| B | MET1-SER190 | |
| B | HIS297-GLY302 | |
| B | SER367-PRO374 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 440 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN191-LEU211 | |
| A | GLY593-GLY613 | |
| A | GLU635-TYR655 | |
| B | ASN191-LEU211 | |
| B | GLY276-LYS296 | |
| B | LEU303-LEU323 | |
| B | SER346-LEU366 | |
| B | GLY375-ALA395 | |
| B | TRP421-PRO441 | |
| B | ILE501-LEU521 | |
| B | ASP530-THR550 | |
| A | GLY276-LYS296 | |
| B | LEU565-LEU585 | |
| B | GLY593-GLY613 | |
| B | GLU635-TYR655 | |
| A | LEU303-LEU323 | |
| A | SER346-LEU366 | |
| A | GLY375-ALA395 | |
| A | TRP421-PRO441 | |
| A | ILE501-LEU521 | |
| A | ASP530-THR550 | |
| A | LEU565-LEU585 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 256 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG212-ARG275 | |
| B | LEU522-LYS529 | |
| B | TYR586-LYS592 | |
| B | ARG656-ILE663 | |
| A | SER324-ARG345 | |
| A | LYS396-GLN420 | |
| A | LEU522-LYS529 | |
| A | TYR586-LYS592 | |
| A | ARG656-ILE663 | |
| B | ARG212-ARG275 | |
| B | SER324-ARG345 | |
| B | LYS396-GLN420 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:20650889 |
| Chain | Residue | Details |
| A | HIS297 | |
| B | HIS297 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER243 | |
| B | SER243 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER245 | |
| B | SER245 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN94 | |
| A | ASN162 | |
| B | ASN94 | |
| B | ASN162 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN142 | |
| B | ASN142 |
