8VLV
Cryo-EM structure of human HGSNAT in inactive state
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005764 | cellular_component | lysosome |
A | 0005765 | cellular_component | lysosomal membrane |
A | 0005886 | cellular_component | plasma membrane |
A | 0007041 | biological_process | lysosomal transport |
A | 0015019 | molecular_function | heparan-alpha-glucosaminide N-acetyltransferase activity |
A | 0016020 | cellular_component | membrane |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0030200 | biological_process | heparan sulfate proteoglycan catabolic process |
A | 0035579 | cellular_component | specific granule membrane |
A | 0043202 | cellular_component | lysosomal lumen |
A | 0051259 | biological_process | protein complex oligomerization |
A | 0070821 | cellular_component | tertiary granule membrane |
B | 0005764 | cellular_component | lysosome |
B | 0005765 | cellular_component | lysosomal membrane |
B | 0005886 | cellular_component | plasma membrane |
B | 0007041 | biological_process | lysosomal transport |
B | 0015019 | molecular_function | heparan-alpha-glucosaminide N-acetyltransferase activity |
B | 0016020 | cellular_component | membrane |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0030200 | biological_process | heparan sulfate proteoglycan catabolic process |
B | 0035579 | cellular_component | specific granule membrane |
B | 0043202 | cellular_component | lysosomal lumen |
B | 0051259 | biological_process | protein complex oligomerization |
B | 0070821 | cellular_component | tertiary granule membrane |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 584 |
Details | TOPO_DOM: Lumenal, vesicle => ECO:0000255 |
Chain | Residue | Details |
A | MET1-SER190 | |
B | GLY442-GLY500 | |
B | LYS551-ASN564 | |
B | HIS614-LYS634 | |
A | HIS297-GLY302 | |
A | SER367-PRO374 | |
A | GLY442-GLY500 | |
A | LYS551-ASN564 | |
A | HIS614-LYS634 | |
B | MET1-SER190 | |
B | HIS297-GLY302 | |
B | SER367-PRO374 |
site_id | SWS_FT_FI2 |
Number of Residues | 440 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
A | ASN191-LEU211 | |
A | GLY593-GLY613 | |
A | GLU635-TYR655 | |
B | ASN191-LEU211 | |
B | GLY276-LYS296 | |
B | LEU303-LEU323 | |
B | SER346-LEU366 | |
B | GLY375-ALA395 | |
B | TRP421-PRO441 | |
B | ILE501-LEU521 | |
B | ASP530-THR550 | |
A | GLY276-LYS296 | |
B | LEU565-LEU585 | |
B | GLY593-GLY613 | |
B | GLU635-TYR655 | |
A | LEU303-LEU323 | |
A | SER346-LEU366 | |
A | GLY375-ALA395 | |
A | TRP421-PRO441 | |
A | ILE501-LEU521 | |
A | ASP530-THR550 | |
A | LEU565-LEU585 |
site_id | SWS_FT_FI3 |
Number of Residues | 256 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | ARG212-ARG275 | |
B | LEU522-LYS529 | |
B | TYR586-LYS592 | |
B | ARG656-ILE663 | |
A | SER324-ARG345 | |
A | LYS396-GLN420 | |
A | LEU522-LYS529 | |
A | TYR586-LYS592 | |
A | ARG656-ILE663 | |
B | ARG212-ARG275 | |
B | SER324-ARG345 | |
B | LYS396-GLN420 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:20650889 |
Chain | Residue | Details |
A | HIS297 | |
B | HIS297 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER243 | |
B | SER243 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER245 | |
B | SER245 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN94 | |
A | ASN162 | |
B | ASN94 | |
B | ASN162 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
Chain | Residue | Details |
A | ASN142 | |
B | ASN142 |