8VLI
Cryo-EM structure of human HGSNAT bound with CoA and product analog
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007041 | biological_process | lysosomal transport |
| A | 0015019 | molecular_function | heparan-alpha-glucosaminide N-acetyltransferase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0030200 | biological_process | heparan sulfate proteoglycan catabolic process |
| A | 0035579 | cellular_component | specific granule membrane |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0051259 | biological_process | protein complex oligomerization |
| A | 0070821 | cellular_component | tertiary granule membrane |
| B | 0005764 | cellular_component | lysosome |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007041 | biological_process | lysosomal transport |
| B | 0015019 | molecular_function | heparan-alpha-glucosaminide N-acetyltransferase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0030200 | biological_process | heparan sulfate proteoglycan catabolic process |
| B | 0035579 | cellular_component | specific granule membrane |
| B | 0043202 | cellular_component | lysosomal lumen |
| B | 0051259 | biological_process | protein complex oligomerization |
| B | 0070821 | cellular_component | tertiary granule membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 440 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 206 |
| Details | Topological domain: {"description":"Lumenal, vesicle","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 106 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Region: {"description":"Lysosomal targeting region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"20650889","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
