8VJ9

CryoEM structure of human ACKR3 phosphorylated by GRK5 in complex with Arrestin3 variant with the C edge loop from Arrestin2 inserted

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007165	biological_process	signal transduction
R	0001525	biological_process	angiogenesis
R	0001570	biological_process	vasculogenesis
R	0004930	molecular_function	G protein-coupled receptor activity
R	0005044	molecular_function	scavenger receptor activity
R	0005515	molecular_function	protein binding
R	0005768	cellular_component	endosome
R	0005769	cellular_component	early endosome
R	0005886	cellular_component	plasma membrane
R	0005905	cellular_component	clathrin-coated pit
R	0006935	biological_process	chemotaxis
R	0006955	biological_process	immune response
R	0007155	biological_process	cell adhesion
R	0007165	biological_process	signal transduction
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
R	0009897	cellular_component	external side of plasma membrane
R	0009986	cellular_component	cell surface
R	0015026	molecular_function	coreceptor activity
R	0016020	cellular_component	membrane
R	0016493	molecular_function	C-C chemokine receptor activity
R	0016494	molecular_function	C-X-C chemokine receptor activity
R	0019722	biological_process	calcium-mediated signaling
R	0019956	molecular_function	chemokine binding
R	0019957	molecular_function	C-C chemokine binding
R	0019958	molecular_function	C-X-C chemokine binding
R	0021557	biological_process	oculomotor nerve development
R	0031623	biological_process	receptor internalization
R	0055037	cellular_component	recycling endosome
R	0060326	biological_process	cell chemotaxis
R	0070098	biological_process	chemokine-mediated signaling pathway
R	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
R	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
R	1905322	biological_process	positive regulation of mesenchymal stem cell migration

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. GSIfFLTCMSVDRYLsI

Chain	Residue	Details
R	GLY144-ILE160

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site_id	PS00295
Number of Residues	19
Details	ARRESTINS Arrestins signature. FRYGrEDlDVLGLsFrKDL

Chain	Residue	Details
A	PHE62-LEU80

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR213-HIS219
L	TYR193-HIS199

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q91YI4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Hydroxyproline; by PHD2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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