8VIY

15-Lipoxygenase-2 V427L

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0005912	cellular_component	adherens junction
A	0005925	cellular_component	focal adhesion
A	0006629	biological_process	lipid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006915	biological_process	apoptotic process
A	0008285	biological_process	negative regulation of cell population proliferation
A	0008289	molecular_function	lipid binding
A	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
A	0016020	cellular_component	membrane
A	0016165	molecular_function	linoleate 13S-lipoxygenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A	0019369	biological_process	arachidonate metabolic process
A	0019372	biological_process	lipoxygenase pathway
A	0030336	biological_process	negative regulation of cell migration
A	0030850	biological_process	prostate gland development
A	0030856	biological_process	regulation of epithelial cell differentiation
A	0032722	biological_process	positive regulation of chemokine production
A	0034440	biological_process	lipid oxidation
A	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
A	0036403	molecular_function	arachidonate 8(S)-lipoxygenase activity
A	0043651	biological_process	linoleic acid metabolic process
A	0045618	biological_process	positive regulation of keratinocyte differentiation
A	0045786	biological_process	negative regulation of cell cycle
A	0045926	biological_process	negative regulation of growth
A	0046872	molecular_function	metal ion binding
A	0050473	molecular_function	arachidonate 15-lipoxygenase activity
A	0051122	biological_process	hepoxilin biosynthetic process
A	0051213	molecular_function	dioxygenase activity
A	0070062	cellular_component	extracellular exosome
A	0071926	biological_process	endocannabinoid signaling pathway
A	1901696	biological_process	cannabinoid biosynthetic process
A	1990136	molecular_function	linoleate 9S-lipoxygenase activity
A	2001303	biological_process	lipoxin A4 biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00081
Number of Residues	11
Details	LIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. CHPLfKLLiPH

Chain	Residue	Details
A	CYS395-HIS405

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FTCSAKH

Chain	Residue	Details
A	PHE547-HIS553

---

site_id	PS00711
Number of Residues	15
Details	LIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HEaltHlLHSHLLpE

Chain	Residue	Details
A	HIS368-GLU382

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	122
Details	Domain: {"description":"PLAT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00152","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	551
Details	Domain: {"description":"Lipoxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00726","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24497644","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00726","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24497644","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---