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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8VIC

AP-6 bound human TMEM175

This is a non-PDB format compatible entry.

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	132
Details	TOPO_DOM: Cytoplasmic => ECO:0000305\|PubMed:26317472

Chain	Residue	Details
A	MET1-SER33
A	LEU470-CYS504
B	MET1-SER33
B	LEU470-CYS504

site_id	SWS_FT_FI2
Number of Residues	44
Details	TRANSMEM: Helical; Name=TM1-1 => ECO:0000305\|PubMed:32228865, ECO:0007744\|PDB:6WC9, ECO:0007744\|PDB:6WCA, ECO:0007744\|PDB:6WCB, ECO:0007744\|PDB:6WCC

Chain	Residue	Details
A	GLN34-THR56
B	GLN34-THR56

site_id	SWS_FT_FI3
Number of Residues	148
Details	TOPO_DOM: Lumenal => ECO:0000305

Chain	Residue	Details
A	HIS57-ARG77
B	ASP283-ARG309
B	GLN361-ARG375
B	SER441-ARG442
A	LEU129-LEU138
A	PHE206-SER210
A	ASP283-ARG309
A	GLN361-ARG375
A	SER441-ARG442
B	HIS57-ARG77
B	LEU129-LEU138
B	PHE206-SER210

site_id	SWS_FT_FI4
Number of Residues	44
Details	TRANSMEM: Helical; Name=TM2-1 => ECO:0000305\|PubMed:32228865, ECO:0007744\|PDB:6WC9, ECO:0007744\|PDB:6WCA, ECO:0007744\|PDB:6WCB, ECO:0007744\|PDB:6WCC

Chain	Residue	Details
A	ILE78-GLN100
B	ILE78-GLN100

site_id	SWS_FT_FI5
Number of Residues	156
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	VAL101-ASP106
B	ALA397-HIS416
A	ALA161-HIS184
A	ARG231-SER257
A	HIS333-THR338
A	ALA397-HIS416
B	VAL101-ASP106
B	ALA161-HIS184
B	ARG231-SER257
B	HIS333-THR338

site_id	SWS_FT_FI6
Number of Residues	42
Details	TRANSMEM: Helical; Name=TM3-1 => ECO:0000305\|PubMed:32228865, ECO:0007744\|PDB:6WC9, ECO:0007744\|PDB:6WCA, ECO:0007744\|PDB:6WCB, ECO:0007744\|PDB:6WCC

Chain	Residue	Details
A	ASP107-SER128
B	ASP107-SER128

site_id	SWS_FT_FI7
Number of Residues	42
Details	TRANSMEM: Helical; Name=TM4-1 => ECO:0000305\|PubMed:32228865, ECO:0007744\|PDB:6WC9, ECO:0007744\|PDB:6WCA, ECO:0007744\|PDB:6WCB, ECO:0007744\|PDB:6WCC

Chain	Residue	Details
A	GLY139-TYR160
B	GLY139-TYR160

site_id	SWS_FT_FI8
Number of Residues	40
Details	TRANSMEM: Helical; Name=TM5-1 => ECO:0000255

Chain	Residue	Details
A	VAL185-PHE205
B	VAL185-PHE205

site_id	SWS_FT_FI9
Number of Residues	38
Details	TRANSMEM: Helical; Name=TM6-1 => ECO:0000255

Chain	Residue	Details
A	TYR211-CYS230
B	TYR211-CYS230

site_id	SWS_FT_FI10
Number of Residues	48
Details	TRANSMEM: Helical; Name=TM1-2 => ECO:0000305\|PubMed:32228865, ECO:0007744\|PDB:6WC9, ECO:0007744\|PDB:6WCA, ECO:0007744\|PDB:6WCB, ECO:0007744\|PDB:6WCC

Chain	Residue	Details
A	LYS258-GLU282
B	LYS258-GLU282

site_id	SWS_FT_FI11
Number of Residues	44
Details	TRANSMEM: Helical; Name=TM2-2 => ECO:0000305\|PubMed:32228865, ECO:0007744\|PDB:6WC9, ECO:0007744\|PDB:6WCA, ECO:0007744\|PDB:6WCB, ECO:0007744\|PDB:6WCC

Chain	Residue	Details
A	PHE310-LEU332
B	PHE310-LEU332

site_id	SWS_FT_FI12
Number of Residues	42
Details	TRANSMEM: Helical; Name=TM3-2 => ECO:0000305\|PubMed:32228865, ECO:0007744\|PDB:6WC9, ECO:0007744\|PDB:6WCA, ECO:0007744\|PDB:6WCB, ECO:0007744\|PDB:6WCC

Chain	Residue	Details
A	ARG339-GLN360
B	ARG339-GLN360

site_id	SWS_FT_FI13
Number of Residues	40
Details	TRANSMEM: Helical; Name=TM4-2 => ECO:0000305\|PubMed:32228865, ECO:0007744\|PDB:6WC9, ECO:0007744\|PDB:6WCA, ECO:0007744\|PDB:6WCB, ECO:0007744\|PDB:6WCC

Chain	Residue	Details
A	VAL376-THR396
B	VAL376-THR396

site_id	SWS_FT_FI14
Number of Residues	46
Details	TRANSMEM: Helical; Name=TM5-2 => ECO:0000305\|PubMed:32228865, ECO:0007744\|PDB:6WC9, ECO:0007744\|PDB:6WCA, ECO:0007744\|PDB:6WCB, ECO:0007744\|PDB:6WCC

Chain	Residue	Details
A	VAL417-LEU440
B	VAL417-LEU440

site_id	SWS_FT_FI15
Number of Residues	52
Details	TRANSMEM: Helical; Name=TM6-2 => ECO:0000305\|PubMed:32228865, ECO:0007744\|PDB:6WC9, ECO:0007744\|PDB:6WCA, ECO:0007744\|PDB:6WCB, ECO:0007744\|PDB:6WCC

Chain	Residue	Details
A	PHE443-ALA469
B	PHE443-ALA469

site_id	SWS_FT_FI16
Number of Residues	2
Details	SITE: Hydrophobic filter residue 1-1 => ECO:0000269\|PubMed:28723891

Chain	Residue	Details
A	ILE46
B	ILE46

site_id	SWS_FT_FI17
Number of Residues	2
Details	SITE: Hydrophobic filter residue 2-1 => ECO:0000250\|UniProtKB:K9UJK2

Chain	Residue	Details
A	VAL50
B	VAL50

site_id	SWS_FT_FI18
Number of Residues	2
Details	SITE: Hydrophobic filter residue 3-1 => ECO:0000250\|UniProtKB:K9UJK2

Chain	Residue	Details
A	LEU53
B	LEU53

site_id	SWS_FT_FI19
Number of Residues	2
Details	SITE: Hydrophobic filter residue 1-2 => ECO:0000269\|PubMed:28723891

Chain	Residue	Details
A	ILE271
B	ILE271

site_id	SWS_FT_FI20
Number of Residues	2
Details	SITE: Hydrophobic filter residue 2-2 => ECO:0000250\|UniProtKB:K9UJK2

Chain	Residue	Details
A	LEU275
B	LEU275

site_id	SWS_FT_FI21
Number of Residues	2
Details	SITE: Hydrophobic filter residue 3-2 => ECO:0000250\|UniProtKB:K9UJK2

Chain	Residue	Details
A	LEU278
B	LEU278

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18691976

Chain	Residue	Details
A	THR6
B	THR6

223790

PDB entries from 2024-08-14

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