8VDY

Crystal Structure of Delta 114-117 D-Dopachrome Tautomerase (D-DT)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004167	molecular_function	dopachrome isomerase activity
A	0005126	molecular_function	cytokine receptor binding
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0010760	biological_process	negative regulation of macrophage chemotaxis
A	0016829	molecular_function	lyase activity
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0033981	molecular_function	D-dopachrome decarboxylase activity
A	0042438	biological_process	melanin biosynthetic process
A	0050178	molecular_function	phenylpyruvate tautomerase activity
A	0050729	biological_process	positive regulation of inflammatory response
A	0070062	cellular_component	extracellular exosome
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0004167	molecular_function	dopachrome isomerase activity
B	0005126	molecular_function	cytokine receptor binding
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0010760	biological_process	negative regulation of macrophage chemotaxis
B	0016829	molecular_function	lyase activity
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0033981	molecular_function	D-dopachrome decarboxylase activity
B	0042438	biological_process	melanin biosynthetic process
B	0050178	molecular_function	phenylpyruvate tautomerase activity
B	0050729	biological_process	positive regulation of inflammatory response
B	0070062	cellular_component	extracellular exosome
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0004167	molecular_function	dopachrome isomerase activity
C	0005126	molecular_function	cytokine receptor binding
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0010760	biological_process	negative regulation of macrophage chemotaxis
C	0016829	molecular_function	lyase activity
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0033981	molecular_function	D-dopachrome decarboxylase activity
C	0042438	biological_process	melanin biosynthetic process
C	0050178	molecular_function	phenylpyruvate tautomerase activity
C	0050729	biological_process	positive regulation of inflammatory response
C	0070062	cellular_component	extracellular exosome
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
D	0004167	molecular_function	dopachrome isomerase activity
D	0005126	molecular_function	cytokine receptor binding
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0010760	biological_process	negative regulation of macrophage chemotaxis
D	0016829	molecular_function	lyase activity
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0033981	molecular_function	D-dopachrome decarboxylase activity
D	0042438	biological_process	melanin biosynthetic process
D	0050178	molecular_function	phenylpyruvate tautomerase activity
D	0050729	biological_process	positive regulation of inflammatory response
D	0070062	cellular_component	extracellular exosome
D	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
E	0004167	molecular_function	dopachrome isomerase activity
E	0005126	molecular_function	cytokine receptor binding
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0010760	biological_process	negative regulation of macrophage chemotaxis
E	0016829	molecular_function	lyase activity
E	0032760	biological_process	positive regulation of tumor necrosis factor production
E	0033981	molecular_function	D-dopachrome decarboxylase activity
E	0042438	biological_process	melanin biosynthetic process
E	0050178	molecular_function	phenylpyruvate tautomerase activity
E	0050729	biological_process	positive regulation of inflammatory response
E	0070062	cellular_component	extracellular exosome
E	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
F	0004167	molecular_function	dopachrome isomerase activity
F	0005126	molecular_function	cytokine receptor binding
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0010760	biological_process	negative regulation of macrophage chemotaxis
F	0016829	molecular_function	lyase activity
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0033981	molecular_function	D-dopachrome decarboxylase activity
F	0042438	biological_process	melanin biosynthetic process
F	0050178	molecular_function	phenylpyruvate tautomerase activity
F	0050729	biological_process	positive regulation of inflammatory response
F	0070062	cellular_component	extracellular exosome
F	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
G	0004167	molecular_function	dopachrome isomerase activity
G	0005126	molecular_function	cytokine receptor binding
G	0005615	cellular_component	extracellular space
G	0005737	cellular_component	cytoplasm
G	0010760	biological_process	negative regulation of macrophage chemotaxis
G	0016829	molecular_function	lyase activity
G	0032760	biological_process	positive regulation of tumor necrosis factor production
G	0033981	molecular_function	D-dopachrome decarboxylase activity
G	0042438	biological_process	melanin biosynthetic process
G	0050178	molecular_function	phenylpyruvate tautomerase activity
G	0050729	biological_process	positive regulation of inflammatory response
G	0070062	cellular_component	extracellular exosome
G	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
H	0004167	molecular_function	dopachrome isomerase activity
H	0005126	molecular_function	cytokine receptor binding
H	0005615	cellular_component	extracellular space
H	0005737	cellular_component	cytoplasm
H	0010760	biological_process	negative regulation of macrophage chemotaxis
H	0016829	molecular_function	lyase activity
H	0032760	biological_process	positive regulation of tumor necrosis factor production
H	0033981	molecular_function	D-dopachrome decarboxylase activity
H	0042438	biological_process	melanin biosynthetic process
H	0050178	molecular_function	phenylpyruvate tautomerase activity
H	0050729	biological_process	positive regulation of inflammatory response
H	0070062	cellular_component	extracellular exosome
H	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
I	0004167	molecular_function	dopachrome isomerase activity
I	0005126	molecular_function	cytokine receptor binding
I	0005615	cellular_component	extracellular space
I	0005737	cellular_component	cytoplasm
I	0010760	biological_process	negative regulation of macrophage chemotaxis
I	0016829	molecular_function	lyase activity
I	0032760	biological_process	positive regulation of tumor necrosis factor production
I	0033981	molecular_function	D-dopachrome decarboxylase activity
I	0042438	biological_process	melanin biosynthetic process
I	0050178	molecular_function	phenylpyruvate tautomerase activity
I	0050729	biological_process	positive regulation of inflammatory response
I	0070062	cellular_component	extracellular exosome
I	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
J	0004167	molecular_function	dopachrome isomerase activity
J	0005126	molecular_function	cytokine receptor binding
J	0005615	cellular_component	extracellular space
J	0005737	cellular_component	cytoplasm
J	0010760	biological_process	negative regulation of macrophage chemotaxis
J	0016829	molecular_function	lyase activity
J	0032760	biological_process	positive regulation of tumor necrosis factor production
J	0033981	molecular_function	D-dopachrome decarboxylase activity
J	0042438	biological_process	melanin biosynthetic process
J	0050178	molecular_function	phenylpyruvate tautomerase activity
J	0050729	biological_process	positive regulation of inflammatory response
J	0070062	cellular_component	extracellular exosome
J	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
K	0004167	molecular_function	dopachrome isomerase activity
K	0005126	molecular_function	cytokine receptor binding
K	0005615	cellular_component	extracellular space
K	0005737	cellular_component	cytoplasm
K	0010760	biological_process	negative regulation of macrophage chemotaxis
K	0016829	molecular_function	lyase activity
K	0032760	biological_process	positive regulation of tumor necrosis factor production
K	0033981	molecular_function	D-dopachrome decarboxylase activity
K	0042438	biological_process	melanin biosynthetic process
K	0050178	molecular_function	phenylpyruvate tautomerase activity
K	0050729	biological_process	positive regulation of inflammatory response
K	0070062	cellular_component	extracellular exosome
K	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
L	0004167	molecular_function	dopachrome isomerase activity
L	0005126	molecular_function	cytokine receptor binding
L	0005615	cellular_component	extracellular space
L	0005737	cellular_component	cytoplasm
L	0010760	biological_process	negative regulation of macrophage chemotaxis
L	0016829	molecular_function	lyase activity
L	0032760	biological_process	positive regulation of tumor necrosis factor production
L	0033981	molecular_function	D-dopachrome decarboxylase activity
L	0042438	biological_process	melanin biosynthetic process
L	0050178	molecular_function	phenylpyruvate tautomerase activity
L	0050729	biological_process	positive regulation of inflammatory response
L	0070062	cellular_component	extracellular exosome
L	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade

Functional Information from PROSITE/UniProt

site_id	PS01158
Number of Residues	15
Details	MIF Macrophage migration inhibitory factor family signature. EPCAqlsIsSIGvVG

Chain	Residue	Details
A	GLU54-GLY68

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Modified residue: {"description":"N-acetylproline","evidences":[{"source":"UniProtKB","id":"O35215","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O35215","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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