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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8VC6

Voltage gated potassium ion channel Kv1.2 in Potassium

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	732
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:18004376, ECO:0000269\|PubMed:20360102, ECO:0000269\|PubMed:20534430

Chain	Residue	Details
A	MET1-GLY160
C	MET1-GLY160
C	CYS244-ILE254
C	SER311-MET325
A	CYS244-ILE254
A	SER311-MET325
D	MET1-GLY160
D	CYS244-ILE254
D	SER311-MET325
B	MET1-GLY160
B	CYS244-ILE254
B	SER311-MET325

site_id	SWS_FT_FI2
Number of Residues	84
Details	TRANSMEM: Helical; Name=Segment S1 => ECO:0000269\|PubMed:18004376, ECO:0000269\|PubMed:20360102, ECO:0000269\|PubMed:20534430

Chain	Residue	Details
A	PRO161-LEU182
D	PRO161-LEU182
B	PRO161-LEU182
C	PRO161-LEU182

site_id	SWS_FT_FI3
Number of Residues	152
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:18004376, ECO:0000269\|PubMed:20360102, ECO:0000269\|PubMed:20534430, ECO:0000305\|PubMed:12151401

Chain	Residue	Details
A	GLU183-PRO221
D	GLU183-PRO221
B	GLU183-PRO221
C	GLU183-PRO221

site_id	SWS_FT_FI4
Number of Residues	84
Details	TRANSMEM: Helical; Name=Segment S2 => ECO:0000269\|PubMed:18004376, ECO:0000269\|PubMed:20360102, ECO:0000269\|PubMed:20534430

Chain	Residue	Details
A	PHE222-ALA243
D	PHE222-ALA243
B	PHE222-ALA243
C	PHE222-ALA243

site_id	SWS_FT_FI5
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S3 => ECO:0000269\|PubMed:18004376, ECO:0000269\|PubMed:20534430

Chain	Residue	Details
A	MET255-ALA275
D	MET255-ALA275
B	MET255-ALA275
C	MET255-ALA275

site_id	SWS_FT_FI6
Number of Residues	128
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:18004376, ECO:0000269\|PubMed:20360102, ECO:0000269\|PubMed:20534430

Chain	Residue	Details
A	GLU276-SER289
C	GLU276-SER289
C	PHE348-ILE361
C	PRO382-LYS388
A	PHE348-ILE361
A	PRO382-LYS388
D	GLU276-SER289
D	PHE348-ILE361
D	PRO382-LYS388
B	GLU276-SER289
B	PHE348-ILE361
B	PRO382-LYS388

site_id	SWS_FT_FI7
Number of Residues	80
Details	TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269\|PubMed:18004376, ECO:0000269\|PubMed:20534430

Chain	Residue	Details
A	LEU290-HIS310
D	LEU290-HIS310
B	LEU290-HIS310
C	LEU290-HIS310

site_id	SWS_FT_FI8
Number of Residues	84
Details	TRANSMEM: Helical; Name=Segment S5 => ECO:0000269\|PubMed:18004376, ECO:0000269\|PubMed:20360102, ECO:0000269\|PubMed:20534430

Chain	Residue	Details
A	ARG326-TYR347
D	ARG326-TYR347
B	ARG326-TYR347
C	ARG326-TYR347

site_id	SWS_FT_FI9
Number of Residues	44
Details	INTRAMEM: Helical; Name=Pore helix => ECO:0000269\|PubMed:18004376, ECO:0000269\|PubMed:20360102, ECO:0000269\|PubMed:20534430

Chain	Residue	Details
A	PRO362-THR373
D	PRO362-THR373
B	PRO362-THR373
C	PRO362-THR373

site_id	SWS_FT_FI10
Number of Residues	28
Details	INTRAMEM: INTRAMEM => ECO:0000269\|PubMed:18004376, ECO:0000269\|PubMed:20360102, ECO:0000269\|PubMed:20534430

Chain	Residue	Details
A	THR374-VAL381
D	THR374-VAL381
B	THR374-VAL381
C	THR374-VAL381

site_id	SWS_FT_FI11
Number of Residues	112
Details	TRANSMEM: Helical; Name=Segment S6 => ECO:0000269\|PubMed:18004376, ECO:0000269\|PubMed:20360102, ECO:0000269\|PubMed:20534430

Chain	Residue	Details
A	ILE389-TYR417
D	ILE389-TYR417
B	ILE389-TYR417
C	ILE389-TYR417

site_id	SWS_FT_FI12
Number of Residues	324
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:12151401, ECO:0000305

Chain	Residue	Details
A	HIS418-VAL499
D	HIS418-VAL499
B	HIS418-VAL499
C	HIS418-VAL499

site_id	SWS_FT_FI13
Number of Residues	4
Details	SITE: Important for normal, slow channel gating => ECO:0000269\|PubMed:17766348

Chain	Residue	Details
A	THR252
D	THR252
B	THR252
C	THR252

site_id	SWS_FT_FI14
Number of Residues	4
Details	SITE: Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin => ECO:0000305\|PubMed:25514171

Chain	Residue	Details
A	VAL381
D	VAL381
B	VAL381
C	VAL381

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P63141

Chain	Residue	Details
A	TYR429
D	TYR429
B	TYR429
C	TYR429

site_id	SWS_FT_FI16
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P63141

Chain	Residue	Details
A	SER434
D	SER434
B	SER434
C	SER434

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:18003609, ECO:0007744\|PubMed:22673903

Chain	Residue	Details
A	SER440
D	SER440
B	SER440
C	SER440

site_id	SWS_FT_FI18
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:22673903

Chain	Residue	Details
A	SER441
A	SER468
D	SER441
D	SER468
B	SER441
B	SER468
C	SER441
C	SER468

site_id	SWS_FT_FI19
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:18003609, ECO:0000269\|PubMed:21602278

Chain	Residue	Details
A	SER449
D	SER449
B	SER449
C	SER449

site_id	SWS_FT_FI20
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000305\|PubMed:21602278

Chain	Residue	Details
A	TYR458
D	TYR458
B	TYR458
C	TYR458

site_id	SWS_FT_FI21
Number of Residues	4
Details	LIPID: S-palmitoyl cysteine => ECO:0000255

Chain	Residue	Details
A	CYS244
D	CYS244
B	CYS244
C	CYS244

site_id	SWS_FT_FI22
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269\|PubMed:16770729

Chain	Residue	Details
A	GLN207
D	GLN207
B	GLN207
C	GLN207

222415

PDB entries from 2024-07-10

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