8VC4
Voltage gated potassium ion channel Kv1.2 in Sodium
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 732 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
Chain | Residue | Details |
A | MET1-GLY160 | |
D | MET1-GLY160 | |
D | CYS244-ILE254 | |
D | SER311-MET325 | |
A | CYS244-ILE254 | |
A | SER311-MET325 | |
B | MET1-GLY160 | |
B | CYS244-ILE254 | |
B | SER311-MET325 | |
C | MET1-GLY160 | |
C | CYS244-ILE254 | |
C | SER311-MET325 |
site_id | SWS_FT_FI2 |
Number of Residues | 84 |
Details | TRANSMEM: Helical; Name=Segment S1 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
Chain | Residue | Details |
A | PRO161-LEU182 | |
B | PRO161-LEU182 | |
C | PRO161-LEU182 | |
D | PRO161-LEU182 |
site_id | SWS_FT_FI3 |
Number of Residues | 152 |
Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000305|PubMed:12151401 |
Chain | Residue | Details |
A | GLU183-PRO221 | |
B | GLU183-PRO221 | |
C | GLU183-PRO221 | |
D | GLU183-PRO221 |
site_id | SWS_FT_FI4 |
Number of Residues | 84 |
Details | TRANSMEM: Helical; Name=Segment S2 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
Chain | Residue | Details |
A | PHE222-ALA243 | |
B | PHE222-ALA243 | |
C | PHE222-ALA243 | |
D | PHE222-ALA243 |
site_id | SWS_FT_FI5 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20534430 |
Chain | Residue | Details |
A | MET255-ALA275 | |
B | MET255-ALA275 | |
C | MET255-ALA275 | |
D | MET255-ALA275 |
site_id | SWS_FT_FI6 |
Number of Residues | 128 |
Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
Chain | Residue | Details |
A | GLU276-SER289 | |
D | GLU276-SER289 | |
D | PHE348-ILE361 | |
D | PRO382-LYS388 | |
A | PHE348-ILE361 | |
A | PRO382-LYS388 | |
B | GLU276-SER289 | |
B | PHE348-ILE361 | |
B | PRO382-LYS388 | |
C | GLU276-SER289 | |
C | PHE348-ILE361 | |
C | PRO382-LYS388 |
site_id | SWS_FT_FI7 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20534430 |
Chain | Residue | Details |
A | LEU290-HIS310 | |
B | LEU290-HIS310 | |
C | LEU290-HIS310 | |
D | LEU290-HIS310 |
site_id | SWS_FT_FI8 |
Number of Residues | 84 |
Details | TRANSMEM: Helical; Name=Segment S5 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
Chain | Residue | Details |
A | ARG326-TYR347 | |
B | ARG326-TYR347 | |
C | ARG326-TYR347 | |
D | ARG326-TYR347 |
site_id | SWS_FT_FI9 |
Number of Residues | 44 |
Details | INTRAMEM: Helical; Name=Pore helix => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
Chain | Residue | Details |
A | PRO362-THR373 | |
B | PRO362-THR373 | |
C | PRO362-THR373 | |
D | PRO362-THR373 |
site_id | SWS_FT_FI10 |
Number of Residues | 28 |
Details | INTRAMEM: INTRAMEM => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
Chain | Residue | Details |
A | THR374-VAL381 | |
B | THR374-VAL381 | |
C | THR374-VAL381 | |
D | THR374-VAL381 |
site_id | SWS_FT_FI11 |
Number of Residues | 112 |
Details | TRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
Chain | Residue | Details |
A | ILE389-TYR417 | |
B | ILE389-TYR417 | |
C | ILE389-TYR417 | |
D | ILE389-TYR417 |
site_id | SWS_FT_FI12 |
Number of Residues | 324 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:12151401, ECO:0000305 |
Chain | Residue | Details |
A | HIS418-VAL499 | |
B | HIS418-VAL499 | |
C | HIS418-VAL499 | |
D | HIS418-VAL499 |
site_id | SWS_FT_FI13 |
Number of Residues | 4 |
Details | SITE: Important for normal, slow channel gating => ECO:0000269|PubMed:17766348 |
Chain | Residue | Details |
A | THR252 | |
B | THR252 | |
C | THR252 | |
D | THR252 |
site_id | SWS_FT_FI14 |
Number of Residues | 4 |
Details | SITE: Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin => ECO:0000305|PubMed:25514171 |
Chain | Residue | Details |
A | VAL381 | |
B | VAL381 | |
C | VAL381 | |
D | VAL381 |
site_id | SWS_FT_FI15 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P63141 |
Chain | Residue | Details |
A | TYR429 | |
B | TYR429 | |
C | TYR429 | |
D | TYR429 |
site_id | SWS_FT_FI16 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P63141 |
Chain | Residue | Details |
A | SER434 | |
B | SER434 | |
C | SER434 | |
D | SER434 |
site_id | SWS_FT_FI17 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:18003609, ECO:0007744|PubMed:22673903 |
Chain | Residue | Details |
A | SER440 | |
B | SER440 | |
C | SER440 | |
D | SER440 |
site_id | SWS_FT_FI18 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
Chain | Residue | Details |
A | SER441 | |
A | SER468 | |
B | SER441 | |
B | SER468 | |
C | SER441 | |
C | SER468 | |
D | SER441 | |
D | SER468 |
site_id | SWS_FT_FI19 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:18003609, ECO:0000269|PubMed:21602278 |
Chain | Residue | Details |
A | SER449 | |
B | SER449 | |
C | SER449 | |
D | SER449 |
site_id | SWS_FT_FI20 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0000305|PubMed:21602278 |
Chain | Residue | Details |
A | TYR458 | |
B | TYR458 | |
C | TYR458 | |
D | TYR458 |
site_id | SWS_FT_FI21 |
Number of Residues | 4 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
Chain | Residue | Details |
A | CYS244 | |
B | CYS244 | |
C | CYS244 | |
D | CYS244 |
site_id | SWS_FT_FI22 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:16770729 |
Chain | Residue | Details |
A | GLN207 | |
B | GLN207 | |
C | GLN207 | |
D | GLN207 |