8VAP

Structure of the E. coli clamp loader bound to the beta clamp in a Fully-Open conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003689	molecular_function	DNA clamp loader activity
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005515	molecular_function	protein binding
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0009360	cellular_component	DNA polymerase III complex
A	0030894	cellular_component	replisome
A	0034061	molecular_function	DNA polymerase activity
A	0043846	cellular_component	DNA polymerase III, clamp loader complex
A	0071897	biological_process	DNA biosynthetic process
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0005524	molecular_function	ATP binding
B	0006260	biological_process	DNA replication
B	0009360	cellular_component	DNA polymerase III complex
B	0016887	molecular_function	ATP hydrolysis activity
C	0003677	molecular_function	DNA binding
C	0003887	molecular_function	DNA-directed DNA polymerase activity
C	0005524	molecular_function	ATP binding
C	0006260	biological_process	DNA replication
C	0009360	cellular_component	DNA polymerase III complex
C	0016887	molecular_function	ATP hydrolysis activity
D	0003677	molecular_function	DNA binding
D	0003887	molecular_function	DNA-directed DNA polymerase activity
D	0005524	molecular_function	ATP binding
D	0006260	biological_process	DNA replication
D	0009360	cellular_component	DNA polymerase III complex
D	0016887	molecular_function	ATP hydrolysis activity
E	0003677	molecular_function	DNA binding
E	0003689	molecular_function	DNA clamp loader activity
E	0003887	molecular_function	DNA-directed DNA polymerase activity
E	0005515	molecular_function	protein binding
E	0006260	biological_process	DNA replication
E	0006261	biological_process	DNA-templated DNA replication
E	0008408	molecular_function	3'-5' exonuclease activity
E	0009360	cellular_component	DNA polymerase III complex
E	0030894	cellular_component	replisome
E	0034061	molecular_function	DNA polymerase activity
E	0043846	cellular_component	DNA polymerase III, clamp loader complex
E	0071897	biological_process	DNA biosynthetic process
F	0003677	molecular_function	DNA binding
F	0003887	molecular_function	DNA-directed DNA polymerase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006260	biological_process	DNA replication
F	0006261	biological_process	DNA-templated DNA replication
F	0006271	biological_process	DNA strand elongation involved in DNA replication
F	0006974	biological_process	DNA damage response
F	0008408	molecular_function	3'-5' exonuclease activity
F	0009360	cellular_component	DNA polymerase III complex
F	0030174	biological_process	regulation of DNA-templated DNA replication initiation
F	0030894	cellular_component	replisome
F	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
F	0042276	biological_process	error-prone translesion synthesis
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0044787	biological_process	bacterial-type DNA replication
F	1990078	cellular_component	replication inhibiting complex
F	1990085	cellular_component	Hda-beta clamp complex
G	0003677	molecular_function	DNA binding
G	0003887	molecular_function	DNA-directed DNA polymerase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006260	biological_process	DNA replication
G	0006261	biological_process	DNA-templated DNA replication
G	0006271	biological_process	DNA strand elongation involved in DNA replication
G	0006974	biological_process	DNA damage response
G	0008408	molecular_function	3'-5' exonuclease activity
G	0009360	cellular_component	DNA polymerase III complex
G	0030174	biological_process	regulation of DNA-templated DNA replication initiation
G	0030894	cellular_component	replisome
G	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
G	0042276	biological_process	error-prone translesion synthesis
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0044787	biological_process	bacterial-type DNA replication
G	1990078	cellular_component	replication inhibiting complex
G	1990085	cellular_component	Hda-beta clamp complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305|PubMed:18191219

Chain	Residue	Details
F	ARG24
F	GLN149
F	TYR153
G	ARG24
G	GLN149
G	TYR153

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:18191219

Chain	Residue	Details
F	ARG73
D	CYS73
D	CYS76
D	CYS79
G	ARG73
B	CYS76
B	CYS79
C	CYS64
C	CYS73
C	CYS76
C	CYS79
D	CYS64

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