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8V8C

Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596 asymmetric state 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005506molecular_functioniron ion binding
A0006811biological_processmonoatomic ion transport
A0009055molecular_functionelectron transfer activity
A0016020cellular_componentmembrane
A0020037molecular_functionheme binding
A0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
A0022900biological_processelectron transport chain
A0034220biological_processmonoatomic ion transmembrane transport
A0042597cellular_componentperiplasmic space
A0045211cellular_componentpostsynaptic membrane
A0046872molecular_functionmetal ion binding
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005506molecular_functioniron ion binding
B0006811biological_processmonoatomic ion transport
B0009055molecular_functionelectron transfer activity
B0016020cellular_componentmembrane
B0020037molecular_functionheme binding
B0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
B0022900biological_processelectron transport chain
B0034220biological_processmonoatomic ion transmembrane transport
B0042597cellular_componentperiplasmic space
B0045211cellular_componentpostsynaptic membrane
B0046872molecular_functionmetal ion binding
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005506molecular_functioniron ion binding
C0006811biological_processmonoatomic ion transport
C0009055molecular_functionelectron transfer activity
C0016020cellular_componentmembrane
C0020037molecular_functionheme binding
C0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
C0022900biological_processelectron transport chain
C0034220biological_processmonoatomic ion transmembrane transport
C0042597cellular_componentperiplasmic space
C0045211cellular_componentpostsynaptic membrane
C0046872molecular_functionmetal ion binding
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005506molecular_functioniron ion binding
D0006811biological_processmonoatomic ion transport
D0009055molecular_functionelectron transfer activity
D0016020cellular_componentmembrane
D0020037molecular_functionheme binding
D0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
D0022900biological_processelectron transport chain
D0034220biological_processmonoatomic ion transmembrane transport
D0042597cellular_componentperiplasmic space
D0045211cellular_componentpostsynaptic membrane
D0046872molecular_functionmetal ion binding
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005506molecular_functioniron ion binding
E0006811biological_processmonoatomic ion transport
E0009055molecular_functionelectron transfer activity
E0016020cellular_componentmembrane
E0020037molecular_functionheme binding
E0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
E0022900biological_processelectron transport chain
E0034220biological_processmonoatomic ion transmembrane transport
E0042597cellular_componentperiplasmic space
E0045211cellular_componentpostsynaptic membrane
E0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CyIdVrwFPfDvqhC
ChainResidueDetails
ACYS127-CYS141

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues415
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU208-PRO232
CILE239-ALA257
CTYR273-TYR294
CLEU447-ALA467
DLEU208-PRO232
DILE239-ALA257
DTYR273-TYR294
DLEU447-ALA467
ELEU208-PRO232
EILE239-ALA257
ETYR273-TYR294
AILE239-ALA257
ELEU447-ALA467
ATYR273-TYR294
ALEU447-ALA467
BLEU208-PRO232
BILE239-ALA257
BTYR273-TYR294
BLEU447-ALA467
CLEU208-PRO232

site_idSWS_FT_FI2
Number of Residues15
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN23
DASN23
DASN67
DASN110
EASN23
EASN67
EASN110
AASN67
AASN110
BASN23
BASN67
BASN110
CASN23
CASN67
CASN110

site_idSWS_FT_FI3
Number of Residues10
DetailsBINDING: axial binding residue
ChainResidueDetails
ATRP323
EILE328
AILE327
BTRP321
BILE325
CTRP324
CILE328
DTRP324
DILE328
ETRP324

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PDB entries from 2024-07-24

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