8V6P

Proteus vulgaris tryptophan indole-lyase complexed with 7-aza-L-tryptophan

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006520	biological_process	amino acid metabolic process
A	0006568	biological_process	tryptophan metabolic process
A	0006569	biological_process	tryptophan catabolic process
A	0009034	molecular_function	tryptophanase activity
A	0009072	biological_process	aromatic amino acid metabolic process
A	0016829	molecular_function	lyase activity
A	0016830	molecular_function	carbon-carbon lyase activity
B	0006520	biological_process	amino acid metabolic process
B	0006568	biological_process	tryptophan metabolic process
B	0006569	biological_process	tryptophan catabolic process
B	0009034	molecular_function	tryptophanase activity
B	0009072	biological_process	aromatic amino acid metabolic process
B	0016829	molecular_function	lyase activity
B	0016830	molecular_function	carbon-carbon lyase activity
C	0006520	biological_process	amino acid metabolic process
C	0006568	biological_process	tryptophan metabolic process
C	0006569	biological_process	tryptophan catabolic process
C	0009034	molecular_function	tryptophanase activity
C	0009072	biological_process	aromatic amino acid metabolic process
C	0016829	molecular_function	lyase activity
C	0016830	molecular_function	carbon-carbon lyase activity
D	0006520	biological_process	amino acid metabolic process
D	0006568	biological_process	tryptophan metabolic process
D	0006569	biological_process	tryptophan catabolic process
D	0009034	molecular_function	tryptophanase activity
D	0009072	biological_process	aromatic amino acid metabolic process
D	0016829	molecular_function	lyase activity
D	0016830	molecular_function	carbon-carbon lyase activity

Functional Information from PROSITE/UniProt

site_id	PS00853
Number of Residues	19
Details	BETA_ELIM_LYASE Beta-eliminating lyases pyridoxal-phosphate attachment site. YaDaltMSAKKDpLLnIGG

Chain	Residue	Details
A	TYR256-GLY274

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N6-(pyridoxal phosphate)lysine

Chain	Residue	Details
A	LYS266
B	LYS266
C	LYS266
D	LYS266

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 410

Chain	Residue	Details
A	TYR72	proton shuttle (general acid/base)
A	PHE132	steric role
A	ASP133	electrostatic stabiliser, proton shuttle (general acid/base)
A	ASP223	electrostatic stabiliser
A	ALA225	steric role
A	LYS266	covalent catalysis, proton shuttle (general acid/base)
A	HIS458	activator, electrostatic stabiliser

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site_id	MCSA2
Number of Residues	7
Details	M-CSA 410

Chain	Residue	Details
B	TYR72	proton shuttle (general acid/base)
B	PHE132	steric role
B	ASP133	electrostatic stabiliser, proton shuttle (general acid/base)
B	ASP223	electrostatic stabiliser
B	ALA225	steric role
B	LYS266	covalent catalysis, proton shuttle (general acid/base)
B	HIS458	activator, electrostatic stabiliser

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site_id	MCSA3
Number of Residues	7
Details	M-CSA 410

Chain	Residue	Details
C	TYR72	proton shuttle (general acid/base)
C	PHE132	steric role
C	ASP133	electrostatic stabiliser, proton shuttle (general acid/base)
C	ASP223	electrostatic stabiliser
C	ALA225	steric role
C	LYS266	covalent catalysis, proton shuttle (general acid/base)
C	HIS458	activator, electrostatic stabiliser

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site_id	MCSA4
Number of Residues	7
Details	M-CSA 410

Chain	Residue	Details
D	TYR72	proton shuttle (general acid/base)
D	PHE132	steric role
D	ASP133	electrostatic stabiliser, proton shuttle (general acid/base)
D	ASP223	electrostatic stabiliser
D	ALA225	steric role
D	LYS266	covalent catalysis, proton shuttle (general acid/base)
D	HIS458	activator, electrostatic stabiliser

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