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8V6K

Apo-state cryo-EM structure of human TRPV3 in cNW30 nanodiscs

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0009266biological_processresponse to temperature stimulus
A0016020cellular_componentmembrane
A0042636biological_processnegative regulation of hair cycle
A0043235cellular_componentreceptor complex
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0090280biological_processpositive regulation of calcium ion import
B0005216molecular_functionmonoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0009266biological_processresponse to temperature stimulus
B0016020cellular_componentmembrane
B0042636biological_processnegative regulation of hair cycle
B0043235cellular_componentreceptor complex
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0090280biological_processpositive regulation of calcium ion import
C0005216molecular_functionmonoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0009266biological_processresponse to temperature stimulus
C0016020cellular_componentmembrane
C0042636biological_processnegative regulation of hair cycle
C0043235cellular_componentreceptor complex
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0090280biological_processpositive regulation of calcium ion import
D0005216molecular_functionmonoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0009266biological_processresponse to temperature stimulus
D0016020cellular_componentmembrane
D0042636biological_processnegative regulation of hair cycle
D0043235cellular_componentreceptor complex
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0090280biological_processpositive regulation of calcium ion import
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2372
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-HIS439
CARG509-HIS523
CARG567-LYS589
CASN671-SER790
DMET1-HIS439
DARG509-HIS523
DARG567-LYS589
DASN671-SER790
AARG509-HIS523
AARG567-LYS589
AASN671-SER790
BMET1-HIS439
BARG509-HIS523
BARG567-LYS589
BASN671-SER790
CMET1-HIS439

site_idSWS_FT_FI2
Number of Residues480
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AMET440-TYR460
BGLU546-THR566
BPHE590-GLU610
BTYR650-LEU670
CMET440-TYR460
CMET488-LEU508
CPHE524-TYR544
CGLU546-THR566
CPHE590-GLU610
CTYR650-LEU670
DMET440-TYR460
AMET488-LEU508
DMET488-LEU508
DPHE524-TYR544
DGLU546-THR566
DPHE590-GLU610
DTYR650-LEU670
APHE524-TYR544
AGLU546-THR566
APHE590-GLU610
ATYR650-LEU670
BMET440-TYR460
BMET488-LEU508
BPHE524-TYR544

site_idSWS_FT_FI3
Number of Residues108
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ATYR461-ARG487
ALYS545
BTYR461-ARG487
BLYS545
CTYR461-ARG487
CLYS545
DTYR461-ARG487
DLYS545

site_idSWS_FT_FI4
Number of Residues64
DetailsINTRAMEM: Pore-forming => ECO:0000255
ChainResidueDetails
ASER621-ILE637
BSER621-ILE637
CSER621-ILE637
DSER621-ILE637

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PDB entries from 2024-10-30

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