Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8V6K

Apo-state cryo-EM structure of human TRPV3 in cNW30 nanodiscs

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0007015	biological_process	actin filament organization
A	0007231	biological_process	osmosensory signaling pathway
A	0009266	biological_process	response to temperature stimulus
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042636	biological_process	negative regulation of hair cycle
A	0042802	molecular_function	identical protein binding
A	0043235	cellular_component	receptor complex
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0090280	biological_process	positive regulation of calcium ion import
A	0098703	biological_process	calcium ion import across plasma membrane
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0007015	biological_process	actin filament organization
B	0007231	biological_process	osmosensory signaling pathway
B	0009266	biological_process	response to temperature stimulus
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042636	biological_process	negative regulation of hair cycle
B	0042802	molecular_function	identical protein binding
B	0043235	cellular_component	receptor complex
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0090280	biological_process	positive regulation of calcium ion import
B	0098703	biological_process	calcium ion import across plasma membrane
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0007015	biological_process	actin filament organization
C	0007231	biological_process	osmosensory signaling pathway
C	0009266	biological_process	response to temperature stimulus
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042636	biological_process	negative regulation of hair cycle
C	0042802	molecular_function	identical protein binding
C	0043235	cellular_component	receptor complex
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0090280	biological_process	positive regulation of calcium ion import
C	0098703	biological_process	calcium ion import across plasma membrane
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005886	cellular_component	plasma membrane
D	0005929	cellular_component	cilium
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0007015	biological_process	actin filament organization
D	0007231	biological_process	osmosensory signaling pathway
D	0009266	biological_process	response to temperature stimulus
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042636	biological_process	negative regulation of hair cycle
D	0042802	molecular_function	identical protein binding
D	0043235	cellular_component	receptor complex
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0090280	biological_process	positive regulation of calcium ion import
D	0098703	biological_process	calcium ion import across plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2176
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:37648856, ECO:0000269\|PubMed:38691614, ECO:0007744\|PDB:8GKA, ECO:0007744\|PDB:8V6K, ECO:0007744\|PDB:8V6L, ECO:0007744\|PDB:8V6M, ECO:0007744\|PDB:8V6N, ECO:0007744\|PDB:8V6O

Chain	Residue	Details
A	MET1-HIS430
C	ARG509-ASP519
C	ARG567-PHE569
C	GLU687-SER790
D	MET1-HIS430
D	ARG509-ASP519
D	ARG567-PHE569
D	GLU687-SER790
A	ARG509-ASP519
A	ARG567-PHE569
A	GLU687-SER790
B	MET1-HIS430
B	ARG509-ASP519
B	ARG567-PHE569
B	GLU687-SER790
C	MET1-HIS430

site_id	SWS_FT_FI2
Number of Residues	116
Details	TRANSMEM: Helical; Name=S1 => ECO:0000269\|PubMed:37648856, ECO:0000269\|PubMed:38691614, ECO:0007744\|PDB:8GKA, ECO:0007744\|PDB:8V6K, ECO:0007744\|PDB:8V6L, ECO:0007744\|PDB:8V6M, ECO:0007744\|PDB:8V6N, ECO:0007744\|PDB:8V6O

Chain	Residue	Details
A	MET431-TYR460
B	MET431-TYR460
C	MET431-TYR460
D	MET431-TYR460

site_id	SWS_FT_FI3
Number of Residues	140
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:37648856, ECO:0000269\|PubMed:38691614, ECO:0007744\|PDB:8GKA, ECO:0007744\|PDB:8V6K, ECO:0007744\|PDB:8V6L, ECO:0007744\|PDB:8V6M, ECO:0007744\|PDB:8V6N, ECO:0007744\|PDB:8V6O

Chain	Residue	Details
A	TYR461-MET479
C	LEU541-LYS545
C	ILE609-SER620
C	ASN647-LYS649
D	TYR461-MET479
D	LEU541-LYS545
D	ILE609-SER620
D	ASN647-LYS649
A	LEU541-LYS545
A	ILE609-SER620
A	ASN647-LYS649
B	TYR461-MET479
B	LEU541-LYS545
B	ILE609-SER620
B	ASN647-LYS649
C	TYR461-MET479

site_id	SWS_FT_FI4
Number of Residues	112
Details	TRANSMEM: Helical; Name=S2 => ECO:0000269\|PubMed:37648856, ECO:0000269\|PubMed:38691614, ECO:0007744\|PDB:8GKA, ECO:0007744\|PDB:8V6K, ECO:0007744\|PDB:8V6L, ECO:0007744\|PDB:8V6M, ECO:0007744\|PDB:8V6N, ECO:0007744\|PDB:8V6O

Chain	Residue	Details
A	GLY480-LEU508
B	GLY480-LEU508
C	GLY480-LEU508
D	GLY480-LEU508

site_id	SWS_FT_FI5
Number of Residues	80
Details	TRANSMEM: Helical; Name=S3 => ECO:0000269\|PubMed:37648856, ECO:0000269\|PubMed:38691614, ECO:0007744\|PDB:8GKA, ECO:0007744\|PDB:8V6K, ECO:0007744\|PDB:8V6L, ECO:0007744\|PDB:8V6M, ECO:0007744\|PDB:8V6N, ECO:0007744\|PDB:8V6O

Chain	Residue	Details
A	ALA520-TYR540
B	ALA520-TYR540
C	ALA520-TYR540
D	ALA520-TYR540

site_id	SWS_FT_FI6
Number of Residues	80
Details	TRANSMEM: Helical; Name=S4 => ECO:0000269\|PubMed:37648856, ECO:0000269\|PubMed:38691614, ECO:0007744\|PDB:8GKA, ECO:0007744\|PDB:8V6K, ECO:0007744\|PDB:8V6L, ECO:0007744\|PDB:8V6M, ECO:0007744\|PDB:8V6N, ECO:0007744\|PDB:8V6O

Chain	Residue	Details
A	GLU546-THR566
B	GLU546-THR566
C	GLU546-THR566
D	GLU546-THR566

site_id	SWS_FT_FI7
Number of Residues	152
Details	TRANSMEM: Helical; Name=S5 => ECO:0000269\|PubMed:37648856, ECO:0000269\|PubMed:38691614, ECO:0007744\|PDB:8GKA, ECO:0007744\|PDB:8V6K, ECO:0007744\|PDB:8V6L, ECO:0007744\|PDB:8V6M, ECO:0007744\|PDB:8V6N, ECO:0007744\|PDB:8V6O

Chain	Residue	Details
A	GLN570-LEU608
B	GLN570-LEU608
C	GLN570-LEU608
D	GLN570-LEU608

site_id	SWS_FT_FI8
Number of Residues	100
Details	INTRAMEM: Pore-forming => ECO:0000269\|PubMed:37648856, ECO:0000269\|PubMed:38691614, ECO:0007744\|PDB:8GKA, ECO:0007744\|PDB:8V6K, ECO:0007744\|PDB:8V6L, ECO:0007744\|PDB:8V6M, ECO:0007744\|PDB:8V6N, ECO:0007744\|PDB:8V6O

Chain	Residue	Details
A	SER621-GLN646
B	SER621-GLN646
C	SER621-GLN646
D	SER621-GLN646

site_id	SWS_FT_FI9
Number of Residues	144
Details	TRANSMEM: Helical; Name=S6 => ECO:0000269\|PubMed:37648856, ECO:0000269\|PubMed:38691614, ECO:0007744\|PDB:8GKA, ECO:0007744\|PDB:8V6K, ECO:0007744\|PDB:8V6L, ECO:0007744\|PDB:8V6M, ECO:0007744\|PDB:8V6N, ECO:0007744\|PDB:8V6O

Chain	Residue	Details
A	TYR650-LYS686
B	TYR650-LYS686
C	TYR650-LYS686
D	TYR650-LYS686

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:37648856, ECO:0000269\|PubMed:38691614, ECO:0007744\|PDB:8GKA, ECO:0007744\|PDB:8V6K, ECO:0007744\|PDB:8V6M

Chain	Residue	Details
A	GLY638
B	GLY638
C	GLY638
D	GLY638

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)