8V5R
Active conformation of DNA polymerase gamma bound to DNA
Functional Information from PROSITE/UniProt
| site_id | PS00447 |
| Number of Residues | 20 |
| Details | DNA_POLYMERASE_A DNA polymerase family A signature. RehAKifnYGriYgaGqpfA |
| Chain | Residue | Details |
| A | ARG943-ALA962 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER38 | |
| C | SER38 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37202477, ECO:0007744|PDB:8D37 |
| Chain | Residue | Details |
| A | SER306 | |
| A | LYS806 | |
| A | SER893 | |
| A | ARG943 | |
| A | SER1095 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:26056153, ECO:0007744|PDB:4ZTZ |
| Chain | Residue | Details |
| A | ARG579 | |
| A | ARG869 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26056153, ECO:0000269|PubMed:37202477, ECO:0007744|PDB:4ZTZ, ECO:0007744|PDB:8D37 |
| Chain | Residue | Details |
| A | SER593 | |
| A | LYS947 | |
| A | TYR951 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:37202477, ECO:0007744|PDB:8D37 |
| Chain | Residue | Details |
| A | HIS754 | |
| A | GLY763 | |
| A | LYS768 | |
| A | SER863 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26056153, ECO:0007744|PDB:4ZTZ |
| Chain | Residue | Details |
| A | THR849 | |
| A | ASP890 | |
| A | VAL891 | |
| A | GLU895 | |
| A | THR1094 | |
| A | ASP1135 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Critical for replication fidelity and mismatch recognition => ECO:0000269|PubMed:37202477 |
| Chain | Residue | Details |
| A | ARG853 | |
| A | GLN1102 |
