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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8V4S

Cryo-EM structure of the rat P2X7 receptor in the apo closed state purified in the absence of sodium

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001614molecular_functionpurinergic nucleotide receptor activity
A0001934biological_processpositive regulation of protein phosphorylation
A0002028biological_processregulation of sodium ion transport
A0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
A0005102molecular_functionsignaling receptor binding
A0005216molecular_functionmonoatomic ion channel activity
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005635cellular_componentnuclear envelope
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0007166biological_processcell surface receptor signaling pathway
A0008270molecular_functionzinc ion binding
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0019228biological_processneuronal action potential
A0032059cellular_componentbleb
A0032060biological_processbleb assembly
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032991cellular_componentprotein-containing complex
A0033198biological_processresponse to ATP
A0035725biological_processsodium ion transmembrane transport
A0038023molecular_functionsignaling receptor activity
A0042802molecular_functionidentical protein binding
A0043195cellular_componentterminal bouton
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0045202cellular_componentsynapse
A0046931biological_processpore complex assembly
A0051130biological_processpositive regulation of cellular component organization
A0051495biological_processpositive regulation of cytoskeleton organization
A0051503biological_processadenine nucleotide transport
A0051899biological_processmembrane depolarization
A0060079biological_processexcitatory postsynaptic potential
A0070588biological_processcalcium ion transmembrane transport
A0071805biological_processpotassium ion transmembrane transport
A0097110molecular_functionscaffold protein binding
A0097190biological_processapoptotic signaling pathway
A0097191biological_processextrinsic apoptotic signaling pathway
A0098655biological_processmonoatomic cation transmembrane transport
A0098794cellular_componentpostsynapse
A0099161biological_processregulation of presynaptic dense core granule exocytosis
A1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
A1903530biological_processregulation of secretion by cell
A1904669biological_processATP export
B0000287molecular_functionmagnesium ion binding
B0001614molecular_functionpurinergic nucleotide receptor activity
B0001934biological_processpositive regulation of protein phosphorylation
B0002028biological_processregulation of sodium ion transport
B0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
B0005102molecular_functionsignaling receptor binding
B0005216molecular_functionmonoatomic ion channel activity
B0005507molecular_functioncopper ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005635cellular_componentnuclear envelope
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0007166biological_processcell surface receptor signaling pathway
B0008270molecular_functionzinc ion binding
B0015267molecular_functionchannel activity
B0016020cellular_componentmembrane
B0019228biological_processneuronal action potential
B0032059cellular_componentbleb
B0032060biological_processbleb assembly
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032991cellular_componentprotein-containing complex
B0033198biological_processresponse to ATP
B0035725biological_processsodium ion transmembrane transport
B0038023molecular_functionsignaling receptor activity
B0042802molecular_functionidentical protein binding
B0043195cellular_componentterminal bouton
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0045202cellular_componentsynapse
B0046931biological_processpore complex assembly
B0051130biological_processpositive regulation of cellular component organization
B0051495biological_processpositive regulation of cytoskeleton organization
B0051503biological_processadenine nucleotide transport
B0051899biological_processmembrane depolarization
B0060079biological_processexcitatory postsynaptic potential
B0070588biological_processcalcium ion transmembrane transport
B0071805biological_processpotassium ion transmembrane transport
B0097110molecular_functionscaffold protein binding
B0097190biological_processapoptotic signaling pathway
B0097191biological_processextrinsic apoptotic signaling pathway
B0098655biological_processmonoatomic cation transmembrane transport
B0098794cellular_componentpostsynapse
B0099161biological_processregulation of presynaptic dense core granule exocytosis
B1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
B1903530biological_processregulation of secretion by cell
B1904669biological_processATP export
C0000287molecular_functionmagnesium ion binding
C0001614molecular_functionpurinergic nucleotide receptor activity
C0001934biological_processpositive regulation of protein phosphorylation
C0002028biological_processregulation of sodium ion transport
C0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
C0005102molecular_functionsignaling receptor binding
C0005216molecular_functionmonoatomic ion channel activity
C0005507molecular_functioncopper ion binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005635cellular_componentnuclear envelope
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0007166biological_processcell surface receptor signaling pathway
C0008270molecular_functionzinc ion binding
C0015267molecular_functionchannel activity
C0016020cellular_componentmembrane
C0019228biological_processneuronal action potential
C0032059cellular_componentbleb
C0032060biological_processbleb assembly
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032991cellular_componentprotein-containing complex
C0033198biological_processresponse to ATP
C0035725biological_processsodium ion transmembrane transport
C0038023molecular_functionsignaling receptor activity
C0042802molecular_functionidentical protein binding
C0043195cellular_componentterminal bouton
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0045202cellular_componentsynapse
C0046931biological_processpore complex assembly
C0051130biological_processpositive regulation of cellular component organization
C0051495biological_processpositive regulation of cytoskeleton organization
C0051503biological_processadenine nucleotide transport
C0051899biological_processmembrane depolarization
C0060079biological_processexcitatory postsynaptic potential
C0070588biological_processcalcium ion transmembrane transport
C0071805biological_processpotassium ion transmembrane transport
C0097110molecular_functionscaffold protein binding
C0097190biological_processapoptotic signaling pathway
C0097191biological_processextrinsic apoptotic signaling pathway
C0098655biological_processmonoatomic cation transmembrane transport
C0098794cellular_componentpostsynapse
C0099161biological_processregulation of presynaptic dense core granule exocytosis
C1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
C1903530biological_processregulation of secretion by cell
C1904669biological_processATP export
Functional Information from PROSITE/UniProt
site_idPS01212
Number of Residues27
DetailsP2X_RECEPTOR ATP P2X receptors signature. GGiMGIeIyWdCNLDswshrCqPkYsF
ChainResidueDetails
AGLY249-PHE275
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues69
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"31587896","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9V","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"31587896","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9V","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues51
DetailsRegion: {"description":"C-cys anchor","evidences":[{"source":"PubMed","id":"31587896","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31587896","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9W","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"39107314","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39365862","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TR7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31587896","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39107314","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39365862","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TR5","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6U9V","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues21
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"39107314","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TR5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues3
DetailsSite: {"description":"Selectivity filter 1","evidences":[{"source":"UniProtKB","id":"Q99572","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues3
DetailsModified residue: {"description":"ADP-ribosylarginine","evidences":[{"source":"UniProtKB","id":"Q9Z1M0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues12
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"31587896","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39107314","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9V","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8TR5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"39107314","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TR5","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24090084","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31587896","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39107314","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TR5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31587896","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9V","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24090084","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31587896","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9V","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2026-03-25

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