8V2N

Human SIRT3 co-crystallized with ligands, including p53-AMC peptide and Carba-NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017136	molecular_function	NAD-dependent histone deacetylase activity
A	0051287	molecular_function	NAD binding
A	0070403	molecular_function	NAD+ binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18794531

Chain	Residue	Details
A	HIS248

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:23897466

Chain	Residue	Details
A	GLY145
A	GLN228
A	GLY319
A	ASN344

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:23897466

Chain	Residue	Details
A	CYS256
A	CYS259
A	CYS280
A	CYS283

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8R104

Chain	Residue	Details
A	LYS122

---