8V2C

Cryo-EM structure of mouse type II OSM receptor complex: model for assembly core region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005147	molecular_function	oncostatin-M receptor binding
A	0005576	cellular_component	extracellular region
A	0006955	biological_process	immune response
A	0038165	biological_process	oncostatin-M-mediated signaling pathway
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00590
Number of Residues	20
Details	LIF_OSM LIF / OSM family signature. TtpdvFNtKigsCgFLwgYH

Chain	Residue	Details
A	THR165-HIS184

---

site_id	PS01353
Number of Residues	52
Details	HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NsmgaSpeslmvlsndsgheevkektikgikdafn......IsWe..Pvsgdtmg..Yv.VdW

Chain	Residue	Details
C	ASN507-TRP558
B	ASN402-TRP455

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	713
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
C	GLU24-MET737
A	ASN44
A	ASN145

---

site_id	SWS_FT_FI2
Number of Residues	11
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN74
C	ASN491
C	ASN541
C	ASN97
C	ASN130
C	ASN162
C	ASN239
C	ASN271
C	ASN304
C	ASN323
C	ASN377

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19656770

Chain	Residue	Details
C	ASN577
C	ASN689
C	ASN722

---