Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8V29

Cryo-EM structure of human type I OSM receptor complex: model for full extracellular assembly

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005147	molecular_function	oncostatin-M receptor binding
A	0005576	cellular_component	extracellular region
A	0006955	biological_process	immune response
A	0038165	biological_process	oncostatin-M-mediated signaling pathway
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00590
Number of Residues	20
Details	LIF_OSM LIF / OSM family signature. PasdaFQrKlegCrFLhgYH

Chain	Residue	Details
A	PRO180-HIS199

site_id	PS01353
Number of Residues	54
Details	HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NlvgkSdaavltipacdfqathpvmdlkafpkdnmlw....VeWtt.Presvkk...Yi.LeW

Chain	Residue	Details
B	ASN404-TRP457
C	ASN611-TRP661

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	91
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	199
Details	Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	194
Details	Domain: {"description":"Fibronectin type-III 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	182
Details	Domain: {"description":"Fibronectin type-III 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8V29","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V29","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V2A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V2A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V29","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V2A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V29","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V29","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V29","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D82","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D82","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	92
Details	Domain: {"description":"Fibronectin type-III 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18775332","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18775332","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8V29","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V2A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18775332","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D7R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8V29","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)