Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8UY6

Aquaporin Z with ALFA tag and bound to nanobody

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006833	biological_process	water transport
A	0006970	biological_process	response to osmotic stress
A	0009992	biological_process	intracellular water homeostasis
A	0015250	molecular_function	water channel activity
A	0015267	molecular_function	channel activity
A	0016020	cellular_component	membrane
A	0042802	molecular_function	identical protein binding
A	0055085	biological_process	transmembrane transport
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006833	biological_process	water transport
C	0006970	biological_process	response to osmotic stress
C	0009992	biological_process	intracellular water homeostasis
C	0015250	molecular_function	water channel activity
C	0015267	molecular_function	channel activity
C	0016020	cellular_component	membrane
C	0042802	molecular_function	identical protein binding
C	0055085	biological_process	transmembrane transport
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0006833	biological_process	water transport
E	0006970	biological_process	response to osmotic stress
E	0009992	biological_process	intracellular water homeostasis
E	0015250	molecular_function	water channel activity
E	0015267	molecular_function	channel activity
E	0016020	cellular_component	membrane
E	0042802	molecular_function	identical protein binding
E	0055085	biological_process	transmembrane transport
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0006833	biological_process	water transport
G	0006970	biological_process	response to osmotic stress
G	0009992	biological_process	intracellular water homeostasis
G	0015250	molecular_function	water channel activity
G	0015267	molecular_function	channel activity
G	0016020	cellular_component	membrane
G	0042802	molecular_function	identical protein binding
G	0055085	biological_process	transmembrane transport
I	0005515	molecular_function	protein binding
I	0005886	cellular_component	plasma membrane
I	0006833	biological_process	water transport
I	0006970	biological_process	response to osmotic stress
I	0009992	biological_process	intracellular water homeostasis
I	0015250	molecular_function	water channel activity
I	0015267	molecular_function	channel activity
I	0016020	cellular_component	membrane
I	0042802	molecular_function	identical protein binding
I	0055085	biological_process	transmembrane transport
K	0005515	molecular_function	protein binding
K	0005886	cellular_component	plasma membrane
K	0006833	biological_process	water transport
K	0006970	biological_process	response to osmotic stress
K	0009992	biological_process	intracellular water homeostasis
K	0015250	molecular_function	water channel activity
K	0015267	molecular_function	channel activity
K	0016020	cellular_component	membrane
K	0042802	molecular_function	identical protein binding
K	0055085	biological_process	transmembrane transport
M	0005515	molecular_function	protein binding
M	0005886	cellular_component	plasma membrane
M	0006833	biological_process	water transport
M	0006970	biological_process	response to osmotic stress
M	0009992	biological_process	intracellular water homeostasis
M	0015250	molecular_function	water channel activity
M	0015267	molecular_function	channel activity
M	0016020	cellular_component	membrane
M	0042802	molecular_function	identical protein binding
M	0055085	biological_process	transmembrane transport
O	0005515	molecular_function	protein binding
O	0005886	cellular_component	plasma membrane
O	0006833	biological_process	water transport
O	0006970	biological_process	response to osmotic stress
O	0009992	biological_process	intracellular water homeostasis
O	0015250	molecular_function	water channel activity
O	0015267	molecular_function	channel activity
O	0016020	cellular_component	membrane
O	0042802	molecular_function	identical protein binding
O	0055085	biological_process	transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00221
Number of Residues	9
Details	MIP MIP family signature. HFNPAVTIG

Chain	Residue	Details
A	HIS61-GLY69

site_id	PS00501
Number of Residues	8
Details	SPASE_I_1 Signal peptidases I serine active site. GYSMLSAL

Chain	Residue	Details
A	GLY128-LEU135

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	288
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	160
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	432
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	160
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	160
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	160
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	160
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	160
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	16
Details	Motif: {"description":"NPA 1"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	16
Details	Motif: {"description":"NPA 2"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	8
Details	Site: {"description":"Involved in tetramerization or stability of the tetramer"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	32
Details	Site: {"description":"Selectivity filter"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)