8UWU

EmrE structure in the proton-bound state (WT/L51I heterodimer)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0006970	biological_process	response to osmotic stress
A	0006974	biological_process	DNA damage response
A	0009410	biological_process	response to xenobiotic stimulus
A	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
A	0015220	molecular_function	choline transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015871	biological_process	choline transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0031460	biological_process	glycine betaine transport
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	1990207	cellular_component	EmrE multidrug transporter complex
A	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
B	0005886	cellular_component	plasma membrane
B	0006805	biological_process	xenobiotic metabolic process
B	0006970	biological_process	response to osmotic stress
B	0006974	biological_process	DNA damage response
B	0009410	biological_process	response to xenobiotic stimulus
B	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
B	0015220	molecular_function	choline transmembrane transporter activity
B	0015297	molecular_function	antiporter activity
B	0015871	biological_process	choline transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0031460	biological_process	glycine betaine transport
B	0042802	molecular_function	identical protein binding
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	1990207	cellular_component	EmrE multidrug transporter complex
B	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"17005200","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"17005200","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"17005200","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"17005200","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Required for proper coupling between the substrate transport and the proton gradient"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Essential for translocation and for substrate and proton binding","evidences":[{"source":"PubMed","id":"12590142","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29114048","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Site: {"description":"Involved in substrate binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Site: {"description":"Important for activity","evidences":[{"source":"PubMed","id":"30287687","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---