8UVE

Structure of NaDC3-Succinate complex in Coo-Ci conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005310	molecular_function	dicarboxylic acid transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0006835	biological_process	dicarboxylic acid transport
A	0006869	biological_process	lipid transport
A	0015137	molecular_function	citrate transmembrane transporter activity
A	0015139	molecular_function	alpha-ketoglutarate transmembrane transporter activity
A	0015141	molecular_function	succinate transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015362	molecular_function	high-affinity sodium:dicarboxylate symporter activity
A	0015370	molecular_function	solute:sodium symporter activity
A	0015711	biological_process	organic anion transport
A	0015742	biological_process	alpha-ketoglutarate transport
A	0015746	biological_process	citrate transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0017153	molecular_function	sodium:dicarboxylate symporter activity
A	0022857	molecular_function	transmembrane transporter activity
A	0034634	molecular_function	glutathione transmembrane transporter activity
A	0034775	biological_process	glutathione transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0055085	biological_process	transmembrane transport
A	0070062	cellular_component	extracellular exosome
A	0071422	biological_process	succinate transmembrane transport
A	0150104	biological_process	transport across blood-brain barrier
B	0005310	molecular_function	dicarboxylic acid transmembrane transporter activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0006835	biological_process	dicarboxylic acid transport
B	0006869	biological_process	lipid transport
B	0015137	molecular_function	citrate transmembrane transporter activity
B	0015139	molecular_function	alpha-ketoglutarate transmembrane transporter activity
B	0015141	molecular_function	succinate transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015362	molecular_function	high-affinity sodium:dicarboxylate symporter activity
B	0015370	molecular_function	solute:sodium symporter activity
B	0015711	biological_process	organic anion transport
B	0015742	biological_process	alpha-ketoglutarate transport
B	0015746	biological_process	citrate transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0017153	molecular_function	sodium:dicarboxylate symporter activity
B	0022857	molecular_function	transmembrane transporter activity
B	0034634	molecular_function	glutathione transmembrane transporter activity
B	0034775	biological_process	glutathione transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0055085	biological_process	transmembrane transport
B	0070062	cellular_component	extracellular exosome
B	0071422	biological_process	succinate transmembrane transport
B	0150104	biological_process	transport across blood-brain barrier

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	74
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	89
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	84
Details	Transmembrane: {"description":"Discontinuously helical; Name=4","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	150
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	82
Details	Transmembrane: {"description":"Discontinuously helical; Name=9","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	60
Details	Transmembrane: {"description":"Discontinuously helical; Name=10","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Motif: {"description":"SNT motif 1","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Motif: {"description":"TXP motif","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Motif: {"description":"SNT motif 2","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	47
Details	Transmembrane: {"description":"Discontinuously helical; Name=5","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---