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8UVC

Structure of NaDC3-aKG complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005310molecular_functiondicarboxylic acid transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006814biological_processsodium ion transport
A0006835biological_processdicarboxylic acid transport
A0006869biological_processlipid transport
A0015137molecular_functioncitrate transmembrane transporter activity
A0015139molecular_functionalpha-ketoglutarate transmembrane transporter activity
A0015141molecular_functionsuccinate transmembrane transporter activity
A0015293molecular_functionsymporter activity
A0015362molecular_functionhigh-affinity sodium:dicarboxylate symporter activity
A0015370molecular_functionsolute:sodium symporter activity
A0015742biological_processalpha-ketoglutarate transport
A0015746biological_processcitrate transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0017153molecular_functionsodium:dicarboxylate symporter activity
A0022857molecular_functiontransmembrane transporter activity
A0034634molecular_functionglutathione transmembrane transporter activity
A0034775biological_processglutathione transmembrane transport
A0035725biological_processsodium ion transmembrane transport
A0055085biological_processtransmembrane transport
A0070062cellular_componentextracellular exosome
A0071422biological_processsuccinate transmembrane transport
A0150104biological_processtransport across blood-brain barrier
B0005310molecular_functiondicarboxylic acid transmembrane transporter activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006814biological_processsodium ion transport
B0006835biological_processdicarboxylic acid transport
B0006869biological_processlipid transport
B0015137molecular_functioncitrate transmembrane transporter activity
B0015139molecular_functionalpha-ketoglutarate transmembrane transporter activity
B0015141molecular_functionsuccinate transmembrane transporter activity
B0015293molecular_functionsymporter activity
B0015362molecular_functionhigh-affinity sodium:dicarboxylate symporter activity
B0015370molecular_functionsolute:sodium symporter activity
B0015742biological_processalpha-ketoglutarate transport
B0015746biological_processcitrate transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0017153molecular_functionsodium:dicarboxylate symporter activity
B0022857molecular_functiontransmembrane transporter activity
B0034634molecular_functionglutathione transmembrane transporter activity
B0034775biological_processglutathione transmembrane transport
B0035725biological_processsodium ion transmembrane transport
B0055085biological_processtransmembrane transport
B0070062cellular_componentextracellular exosome
B0071422biological_processsuccinate transmembrane transport
B0150104biological_processtransport across blood-brain barrier
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues380
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-ARG16
BLEU159-ASN229
BLEU300-GLY336
BSER394-GLN422
BGLU444-ASN461
BTHR527-ARG546
APRO77-CYS82
ALEU159-ASN229
ALEU300-GLY336
ASER394-GLN422
AGLU444-ASN461
ATHR527-ARG546
BMET1-ARG16
BPRO77-CYS82

site_idSWS_FT_FI2
Number of Residues440
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU17-LYS37
APRO506-SER526
ATHR547-ALA567
BLEU17-LYS37
BALA56-LEU76
BPRO83-ILE103
BLEU138-ILE158
BILE230-LEU250
BPHE279-PHE299
BPRO337-PHE357
BPRO373-PRO393
AALA56-LEU76
BVAL462-ALA482
BPRO506-SER526
BTHR547-ALA567
APRO83-ILE103
ALEU138-ILE158
AILE230-LEU250
APHE279-PHE299
APRO337-PHE357
APRO373-PRO393
AVAL462-ALA482

site_idSWS_FT_FI3
Number of Residues294
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLU38-GLU55
BTHR358-ASN372
BSER483-HIS505
BGLN568-LEU602
AGLU104-PHE137
ATHR251-TRP278
ATHR358-ASN372
ASER483-HIS505
AGLN568-LEU602
BGLU38-GLU55
BGLU104-PHE137
BTHR251-TRP278

site_idSWS_FT_FI4
Number of Residues40
DetailsINTRAMEM: Helical => ECO:0000255
ChainResidueDetails
AGLU423-CYS443
BGLU423-CYS443

site_idSWS_FT_FI5
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN586
AASN596
BASN586
BASN596

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PDB entries from 2025-06-11

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