8USN

Intracellular cryo-tomography structure of EBOV nucleocapsid at 8.9 Angstrom

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0019013	cellular_component	viral nucleocapsid
A	0019028	cellular_component	viral capsid
A	0019029	cellular_component	helical viral capsid
A	0019074	biological_process	viral RNA genome packaging
A	0030430	cellular_component	host cell cytoplasm
A	0044423	cellular_component	virion component
A	1990904	cellular_component	ribonucleoprotein complex
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0019013	cellular_component	viral nucleocapsid
B	0019028	cellular_component	viral capsid
B	0019029	cellular_component	helical viral capsid
B	0019074	biological_process	viral RNA genome packaging
B	0030430	cellular_component	host cell cytoplasm
B	0044423	cellular_component	virion component
B	1990904	cellular_component	ribonucleoprotein complex
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0019013	cellular_component	viral nucleocapsid
E	0019028	cellular_component	viral capsid
E	0019029	cellular_component	helical viral capsid
E	0019074	biological_process	viral RNA genome packaging
E	0030430	cellular_component	host cell cytoplasm
E	0044423	cellular_component	virion component
E	1990904	cellular_component	ribonucleoprotein complex
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0006351	biological_process	DNA-templated transcription
F	0010629	biological_process	negative regulation of gene expression
F	0019013	cellular_component	viral nucleocapsid
F	0019079	biological_process	viral genome replication
F	0019083	biological_process	viral transcription
F	0030430	cellular_component	host cell cytoplasm
F	0033235	biological_process	positive regulation of protein sumoylation
F	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
F	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
F	0039557	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
F	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
F	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
F	0039723	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity
F	0039724	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
F	0044423	cellular_component	virion component
F	0052031	biological_process	symbiont-mediated perturbation of host defense response
F	0052170	biological_process	symbiont-mediated suppression of host innate immune response
F	0052562	biological_process	symbiont-mediated suppression of host immune response
F	0060965	biological_process	negative regulation of miRNA-mediated gene silencing
F	0140313	molecular_function	molecular sequestering activity
F	0140533	biological_process	symbiont-mediated suppression of host RNAi-mediated antiviral immune response
I	0005198	molecular_function	structural molecule activity
I	0005515	molecular_function	protein binding
I	0016020	cellular_component	membrane
I	0016032	biological_process	viral process
I	0020002	cellular_component	host cell plasma membrane
I	0033645	cellular_component	host cell endomembrane system
I	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
I	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
I	0044423	cellular_component	virion component
I	0046761	biological_process	viral budding from plasma membrane
I	0046774	biological_process	obsolete suppression by virus of host intracellular interferon activity
I	0052031	biological_process	symbiont-mediated perturbation of host defense response
I	0052170	biological_process	symbiont-mediated suppression of host innate immune response
I	0055036	cellular_component	virion membrane
J	0005198	molecular_function	structural molecule activity
J	0005515	molecular_function	protein binding
J	0016020	cellular_component	membrane
J	0016032	biological_process	viral process
J	0020002	cellular_component	host cell plasma membrane
J	0033645	cellular_component	host cell endomembrane system
J	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
J	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
J	0044423	cellular_component	virion component
J	0046761	biological_process	viral budding from plasma membrane
J	0046774	biological_process	obsolete suppression by virus of host intracellular interferon activity
J	0052031	biological_process	symbiont-mediated perturbation of host defense response
J	0052170	biological_process	symbiont-mediated suppression of host innate immune response
J	0055036	cellular_component	virion membrane
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0006351	biological_process	DNA-templated transcription
K	0010629	biological_process	negative regulation of gene expression
K	0019013	cellular_component	viral nucleocapsid
K	0019079	biological_process	viral genome replication
K	0019083	biological_process	viral transcription
K	0030430	cellular_component	host cell cytoplasm
K	0033235	biological_process	positive regulation of protein sumoylation
K	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
K	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
K	0039557	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
K	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
K	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
K	0039723	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity
K	0039724	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
K	0044423	cellular_component	virion component
K	0052031	biological_process	symbiont-mediated perturbation of host defense response
K	0052170	biological_process	symbiont-mediated suppression of host innate immune response
K	0052562	biological_process	symbiont-mediated suppression of host immune response
K	0060965	biological_process	negative regulation of miRNA-mediated gene silencing
K	0140313	molecular_function	molecular sequestering activity
K	0140533	biological_process	symbiont-mediated suppression of host RNAi-mediated antiviral immune response

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	758
Details	Region: {"description":"NP core","evidences":[{"source":"PubMed","id":"30333622","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"PubMed","id":"31562565","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"PubMed","id":"31562565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31694758","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"28679761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35533195","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	15
Details	Region: {"description":"NP binding region","evidences":[{"source":"PubMed","id":"25865894","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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