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Rpn1/Nub1UBL-focused alignment of the non-substrate-engaged human 26S proteasome

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000502cellular_componentproteasome complex
A0000932cellular_componentP-body
A0001649biological_processosteoblast differentiation
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006511biological_processubiquitin-dependent protein catabolic process
A0008540cellular_componentproteasome regulatory particle, base subcomplex
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0022624cellular_componentproteasome accessory complex
A0034774cellular_componentsecretory granule lumen
A0036402molecular_functionproteasome-activating activity
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A1901800biological_processpositive regulation of proteasomal protein catabolic process
A1904813cellular_componentficolin-1-rich granule lumen
B0000166molecular_functionnucleotide binding
B0000502cellular_componentproteasome complex
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005838cellular_componentproteasome regulatory particle
B0008540cellular_componentproteasome regulatory particle, base subcomplex
B0016020cellular_componentmembrane
B0016887molecular_functionATP hydrolysis activity
B0022624cellular_componentproteasome accessory complex
B0036402molecular_functionproteasome-activating activity
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B1901800biological_processpositive regulation of proteasomal protein catabolic process
U0000502cellular_componentproteasome complex
U0005515molecular_functionprotein binding
U0005576cellular_componentextracellular region
U0005634cellular_componentnucleus
U0005654cellular_componentnucleoplasm
U0005829cellular_componentcytosol
U0005838cellular_componentproteasome regulatory particle
U0008540cellular_componentproteasome regulatory particle, base subcomplex
U0016020cellular_componentmembrane
U0022624cellular_componentproteasome accessory complex
U0030234molecular_functionenzyme regulator activity
U0031625molecular_functionubiquitin protein ligase binding
U0034515cellular_componentproteasome storage granule
U0035578cellular_componentazurophil granule lumen
U0042176biological_processregulation of protein catabolic process
U0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
f0000502cellular_componentproteasome complex
f0005515molecular_functionprotein binding
f0005576cellular_componentextracellular region
f0005634cellular_componentnucleus
f0005654cellular_componentnucleoplasm
f0005829cellular_componentcytosol
f0005838cellular_componentproteasome regulatory particle
f0008540cellular_componentproteasome regulatory particle, base subcomplex
f0016020cellular_componentmembrane
f0022624cellular_componentproteasome accessory complex
f0030234molecular_functionenzyme regulator activity
f0034515cellular_componentproteasome storage granule
f0034774cellular_componentsecretory granule lumen
f0042176biological_processregulation of protein catabolic process
f0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
f0070062cellular_componentextracellular exosome
f1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PROSITE/UniProt
site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. VkVImATNrietLDpALi.R
ChainResidueDetails
BVAL325-ARG343
AILE315-ARG333

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255
ChainResidueDetails
BGLY226

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
BSER4
ALYS422

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
BTHR53

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS258

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR434

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15144186
ChainResidueDetails
BTYR439

site_idSWS_FT_FI7
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:22223895, ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:25807930
ChainResidueDetails
BGLY2

site_idSWS_FT_FI8
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:17370265
ChainResidueDetails
BLYS237

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
USER834

237423

PDB entries from 2025-06-11

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