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8URV

Solution NMR structure of pro-IL-18

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001819biological_processpositive regulation of cytokine production
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006954biological_processinflammatory response
A0007267biological_processcell-cell signaling
A0008283biological_processcell population proliferation
A0010628biological_processpositive regulation of gene expression
A0010744biological_processpositive regulation of macrophage derived foam cell differentiation
A0030101biological_processnatural killer cell activation
A0030155biological_processregulation of cell adhesion
A0030431biological_processsleep
A0032722biological_processpositive regulation of chemokine production
A0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
A0032729biological_processpositive regulation of type II interferon production
A0032736biological_processpositive regulation of interleukin-13 production
A0032740biological_processpositive regulation of interleukin-17 production
A0032819biological_processpositive regulation of natural killer cell proliferation
A0034105biological_processpositive regulation of tissue remodeling
A0035655biological_processinterleukin-18-mediated signaling pathway
A0042088biological_processT-helper 1 type immune response
A0042092biological_processtype 2 immune response
A0042104biological_processpositive regulation of activated T cell proliferation
A0042119biological_processneutrophil activation
A0042267biological_processnatural killer cell mediated cytotoxicity
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0042632biological_processcholesterol homeostasis
A0045515molecular_functioninterleukin-18 receptor binding
A0045630biological_processpositive regulation of T-helper 2 cell differentiation
A0045662biological_processnegative regulation of myoblast differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048018molecular_functionreceptor ligand activity
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0050729biological_processpositive regulation of inflammatory response
A0050830biological_processdefense response to Gram-positive bacterium
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0051142biological_processpositive regulation of NK T cell proliferation
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0061436biological_processestablishment of skin barrier
A0070328biological_processtriglyceride homeostasis
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0150078biological_processpositive regulation of neuroinflammatory response
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A2000556biological_processpositive regulation of T-helper 1 cell cytokine production
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by CASP1, CASP4 and CASP5 => ECO:0000269|PubMed:25261253, ECO:0000269|PubMed:37993712, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:9334240
ChainResidueDetails
AASP36

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Cleavage; by CASP3 => ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:9334240
ChainResidueDetails
AASP71

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PDB entries from 2024-10-09

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