Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8UPP

Campylobacter jejuni ketol-acid reductoisomerase in complex with NADPH and Hoe704

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004455	molecular_function	ketol-acid reductoisomerase activity
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0009082	biological_process	branched-chain amino acid biosynthetic process
A	0009097	biological_process	isoleucine biosynthetic process
A	0009099	biological_process	L-valine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
A	0050661	molecular_function	NADP binding
B	0000287	molecular_function	magnesium ion binding
B	0004455	molecular_function	ketol-acid reductoisomerase activity
B	0005829	cellular_component	cytosol
B	0008652	biological_process	amino acid biosynthetic process
B	0009082	biological_process	branched-chain amino acid biosynthetic process
B	0009097	biological_process	isoleucine biosynthetic process
B	0009099	biological_process	L-valine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0046872	molecular_function	metal ion binding
B	0050661	molecular_function	NADP binding
C	0000287	molecular_function	magnesium ion binding
C	0004455	molecular_function	ketol-acid reductoisomerase activity
C	0005829	cellular_component	cytosol
C	0008652	biological_process	amino acid biosynthetic process
C	0009082	biological_process	branched-chain amino acid biosynthetic process
C	0009097	biological_process	isoleucine biosynthetic process
C	0009099	biological_process	L-valine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0046872	molecular_function	metal ion binding
C	0050661	molecular_function	NADP binding
D	0000287	molecular_function	magnesium ion binding
D	0004455	molecular_function	ketol-acid reductoisomerase activity
D	0005829	cellular_component	cytosol
D	0008652	biological_process	amino acid biosynthetic process
D	0009082	biological_process	branched-chain amino acid biosynthetic process
D	0009097	biological_process	isoleucine biosynthetic process
D	0009099	biological_process	L-valine biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0046872	molecular_function	metal ion binding
D	0050661	molecular_function	NADP binding
E	0000287	molecular_function	magnesium ion binding
E	0004455	molecular_function	ketol-acid reductoisomerase activity
E	0005829	cellular_component	cytosol
E	0008652	biological_process	amino acid biosynthetic process
E	0009082	biological_process	branched-chain amino acid biosynthetic process
E	0009097	biological_process	isoleucine biosynthetic process
E	0009099	biological_process	L-valine biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0046872	molecular_function	metal ion binding
E	0050661	molecular_function	NADP binding
F	0000287	molecular_function	magnesium ion binding
F	0004455	molecular_function	ketol-acid reductoisomerase activity
F	0005829	cellular_component	cytosol
F	0008652	biological_process	amino acid biosynthetic process
F	0009082	biological_process	branched-chain amino acid biosynthetic process
F	0009097	biological_process	isoleucine biosynthetic process
F	0009099	biological_process	L-valine biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0046872	molecular_function	metal ion binding
F	0050661	molecular_function	NADP binding
G	0000287	molecular_function	magnesium ion binding
G	0004455	molecular_function	ketol-acid reductoisomerase activity
G	0005829	cellular_component	cytosol
G	0008652	biological_process	amino acid biosynthetic process
G	0009082	biological_process	branched-chain amino acid biosynthetic process
G	0009097	biological_process	isoleucine biosynthetic process
G	0009099	biological_process	L-valine biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0046872	molecular_function	metal ion binding
G	0050661	molecular_function	NADP binding
H	0000287	molecular_function	magnesium ion binding
H	0004455	molecular_function	ketol-acid reductoisomerase activity
H	0005829	cellular_component	cytosol
H	0008652	biological_process	amino acid biosynthetic process
H	0009082	biological_process	branched-chain amino acid biosynthetic process
H	0009097	biological_process	isoleucine biosynthetic process
H	0009099	biological_process	L-valine biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0046872	molecular_function	metal ion binding
H	0050661	molecular_function	NADP binding
I	0000287	molecular_function	magnesium ion binding
I	0004455	molecular_function	ketol-acid reductoisomerase activity
I	0005829	cellular_component	cytosol
I	0008652	biological_process	amino acid biosynthetic process
I	0009082	biological_process	branched-chain amino acid biosynthetic process
I	0009097	biological_process	isoleucine biosynthetic process
I	0009099	biological_process	L-valine biosynthetic process
I	0016491	molecular_function	oxidoreductase activity
I	0046872	molecular_function	metal ion binding
I	0050661	molecular_function	NADP binding
J	0000287	molecular_function	magnesium ion binding
J	0004455	molecular_function	ketol-acid reductoisomerase activity
J	0005829	cellular_component	cytosol
J	0008652	biological_process	amino acid biosynthetic process
J	0009082	biological_process	branched-chain amino acid biosynthetic process
J	0009097	biological_process	isoleucine biosynthetic process
J	0009099	biological_process	L-valine biosynthetic process
J	0016491	molecular_function	oxidoreductase activity
J	0046872	molecular_function	metal ion binding
J	0050661	molecular_function	NADP binding
K	0000287	molecular_function	magnesium ion binding
K	0004455	molecular_function	ketol-acid reductoisomerase activity
K	0005829	cellular_component	cytosol
K	0008652	biological_process	amino acid biosynthetic process
K	0009082	biological_process	branched-chain amino acid biosynthetic process
K	0009097	biological_process	isoleucine biosynthetic process
K	0009099	biological_process	L-valine biosynthetic process
K	0016491	molecular_function	oxidoreductase activity
K	0046872	molecular_function	metal ion binding
K	0050661	molecular_function	NADP binding
L	0000287	molecular_function	magnesium ion binding
L	0004455	molecular_function	ketol-acid reductoisomerase activity
L	0005829	cellular_component	cytosol
L	0008652	biological_process	amino acid biosynthetic process
L	0009082	biological_process	branched-chain amino acid biosynthetic process
L	0009097	biological_process	isoleucine biosynthetic process
L	0009099	biological_process	L-valine biosynthetic process
L	0016491	molecular_function	oxidoreductase activity
L	0046872	molecular_function	metal ion binding
L	0050661	molecular_function	NADP binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00435

Chain	Residue	Details
B	HIS109
C	HIS109
F	HIS109
A	HIS109
H	HIS109
K	HIS109
I	HIS109
D	HIS109
G	HIS109
J	HIS109
E	HIS109
L	HIS109

site_id	SWS_FT_FI2
Number of Residues	132
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00435

Chain	Residue	Details
B	PHE26
B	GLU232
C	PHE26
C	ARG49
C	SER52
C	SER54
C	ASP84
C	GLY135
C	ASP192
C	GLU196
C	GLU228
C	GLU232
B	SER253
C	SER253
F	PHE26
F	ARG49
F	SER52
F	SER54
F	ASP84
F	GLY135
F	ASP192
F	GLU196
F	GLU228
H	PHE26
F	GLU232
F	SER253
A	PHE26
A	ARG49
A	SER52
A	SER54
A	ASP84
A	GLY135
A	ASP192
A	GLU196
H	ARG49
A	GLU228
A	GLU232
A	SER253
H	SER52
H	SER54
H	ASP84
H	GLY135
H	ASP192
H	GLU196
B	ARG49
H	GLU228
H	GLU232
H	SER253
K	PHE26
K	ARG49
K	SER52
K	SER54
K	ASP84
K	GLY135
K	ASP192
B	SER52
K	GLU196
K	GLU228
K	GLU232
K	SER253
I	PHE26
I	ARG49
I	SER52
I	SER54
I	ASP84
I	GLY135
B	SER54
I	ASP192
I	GLU196
I	GLU228
I	GLU232
I	SER253
D	PHE26
D	ARG49
D	SER52
D	SER54
D	ASP84
B	ASP84
D	GLY135
D	ASP192
D	GLU196
D	GLU228
D	GLU232
D	SER253
G	PHE26
G	ARG49
G	SER52
G	SER54
B	GLY135
G	ASP84
G	GLY135
G	ASP192
G	GLU196
G	GLU228
G	GLU232
G	SER253
J	PHE26
J	ARG49
J	SER52
B	ASP192
J	SER54
J	ASP84
J	GLY135
J	ASP192
J	GLU196
J	GLU228
J	GLU232
J	SER253
E	PHE26
E	ARG49
B	GLU196
E	SER52
E	SER54
E	ASP84
E	GLY135
E	ASP192
E	GLU196
E	GLU228
E	GLU232
E	SER253
L	PHE26
B	GLU228
L	ARG49
L	SER52
L	SER54
L	ASP84
L	GLY135
L	ASP192
L	GLU196
L	GLU228
L	GLU232
L	SER253

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)