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8UKN

APO and AMP-PNP bound cAMP-dependent protein kinase A catalytic domain

Functional Information from GO Data
ChainGOidnamespacecontents
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0001669cellular_componentacrosomal vesicle
C0001707biological_processmesoderm formation
C0001843biological_processneural tube closure
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004691molecular_functioncAMP-dependent protein kinase activity
C0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0005930cellular_componentaxoneme
C0005952cellular_componentcAMP-dependent protein kinase complex
C0006397biological_processmRNA processing
C0006468biological_processprotein phosphorylation
C0006611biological_processprotein export from nucleus
C0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
C0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C0016020cellular_componentmembrane
C0016301molecular_functionkinase activity
C0016607cellular_componentnuclear speck
C0016740molecular_functiontransferase activity
C0018105biological_processpeptidyl-serine phosphorylation
C0019901molecular_functionprotein kinase binding
C0019904molecular_functionprotein domain specific binding
C0021904biological_processdorsal/ventral neural tube patterning
C0030007biological_processintracellular potassium ion homeostasis
C0030145molecular_functionmanganese ion binding
C0031410cellular_componentcytoplasmic vesicle
C0031514cellular_componentmotile cilium
C0031594cellular_componentneuromuscular junction
C0031625molecular_functionubiquitin protein ligase binding
C0032024biological_processpositive regulation of insulin secretion
C0034237molecular_functionprotein kinase A regulatory subunit binding
C0034605biological_processcellular response to heat
C0036126cellular_componentsperm flagellum
C0042995cellular_componentcell projection
C0044853cellular_componentplasma membrane raft
C0045542biological_processpositive regulation of cholesterol biosynthetic process
C0045667biological_processregulation of osteoblast differentiation
C0045722biological_processpositive regulation of gluconeogenesis
C0045879biological_processnegative regulation of smoothened signaling pathway
C0046827biological_processpositive regulation of protein export from nucleus
C0048240biological_processsperm capacitation
C0048471cellular_componentperinuclear region of cytoplasm
C0050766biological_processpositive regulation of phagocytosis
C0050804biological_processmodulation of chemical synaptic transmission
C0051726biological_processregulation of cell cycle
C0061136biological_processregulation of proteasomal protein catabolic process
C0070417biological_processcellular response to cold
C0070613biological_processregulation of protein processing
C0071333biological_processcellular response to glucose stimulus
C0071374biological_processcellular response to parathyroid hormone stimulus
C0071377biological_processcellular response to glucagon stimulus
C0097546cellular_componentciliary base
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099170biological_processpostsynaptic modulation of chemical synaptic transmission
C0106310molecular_functionprotein serine kinase activity
C0141156biological_processcAMP/PKA signal transduction
C1904262biological_processnegative regulation of TORC1 signaling
C1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
C1990044biological_processprotein localization to lipid droplet
C2000810biological_processregulation of bicellular tight junction assembly
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000166molecular_functionnucleotide binding
D0000287molecular_functionmagnesium ion binding
D0001669cellular_componentacrosomal vesicle
D0001707biological_processmesoderm formation
D0001843biological_processneural tube closure
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004691molecular_functioncAMP-dependent protein kinase activity
D0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005929cellular_componentcilium
D0005930cellular_componentaxoneme
D0005952cellular_componentcAMP-dependent protein kinase complex
D0006397biological_processmRNA processing
D0006468biological_processprotein phosphorylation
D0006611biological_processprotein export from nucleus
D0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
D0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
D0016020cellular_componentmembrane
D0016301molecular_functionkinase activity
D0016607cellular_componentnuclear speck
D0016740molecular_functiontransferase activity
D0018105biological_processpeptidyl-serine phosphorylation
D0019901molecular_functionprotein kinase binding
D0019904molecular_functionprotein domain specific binding
D0021904biological_processdorsal/ventral neural tube patterning
D0030007biological_processintracellular potassium ion homeostasis
D0030145molecular_functionmanganese ion binding
D0031410cellular_componentcytoplasmic vesicle
D0031514cellular_componentmotile cilium
D0031594cellular_componentneuromuscular junction
D0031625molecular_functionubiquitin protein ligase binding
D0032024biological_processpositive regulation of insulin secretion
D0034237molecular_functionprotein kinase A regulatory subunit binding
D0034605biological_processcellular response to heat
D0036126cellular_componentsperm flagellum
D0042995cellular_componentcell projection
D0044853cellular_componentplasma membrane raft
D0045542biological_processpositive regulation of cholesterol biosynthetic process
D0045667biological_processregulation of osteoblast differentiation
D0045722biological_processpositive regulation of gluconeogenesis
D0045879biological_processnegative regulation of smoothened signaling pathway
D0046827biological_processpositive regulation of protein export from nucleus
D0048240biological_processsperm capacitation
D0048471cellular_componentperinuclear region of cytoplasm
D0050766biological_processpositive regulation of phagocytosis
D0050804biological_processmodulation of chemical synaptic transmission
D0051726biological_processregulation of cell cycle
D0061136biological_processregulation of proteasomal protein catabolic process
D0070417biological_processcellular response to cold
D0070613biological_processregulation of protein processing
D0071333biological_processcellular response to glucose stimulus
D0071374biological_processcellular response to parathyroid hormone stimulus
D0071377biological_processcellular response to glucagon stimulus
D0097546cellular_componentciliary base
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099170biological_processpostsynaptic modulation of chemical synaptic transmission
D0106310molecular_functionprotein serine kinase activity
D0141156biological_processcAMP/PKA signal transduction
D1904262biological_processnegative regulation of TORC1 signaling
D1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
D1990044biological_processprotein localization to lipid droplet
D2000810biological_processregulation of bicellular tight junction assembly
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0000166molecular_functionnucleotide binding
F0000287molecular_functionmagnesium ion binding
F0001669cellular_componentacrosomal vesicle
F0001707biological_processmesoderm formation
F0001843biological_processneural tube closure
F0004672molecular_functionprotein kinase activity
F0004674molecular_functionprotein serine/threonine kinase activity
F0004691molecular_functioncAMP-dependent protein kinase activity
F0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005813cellular_componentcentrosome
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005929cellular_componentcilium
F0005930cellular_componentaxoneme
F0005952cellular_componentcAMP-dependent protein kinase complex
F0006397biological_processmRNA processing
F0006468biological_processprotein phosphorylation
F0006611biological_processprotein export from nucleus
F0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
F0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
F0016020cellular_componentmembrane
F0016301molecular_functionkinase activity
F0016607cellular_componentnuclear speck
F0016740molecular_functiontransferase activity
F0018105biological_processpeptidyl-serine phosphorylation
F0019901molecular_functionprotein kinase binding
F0019904molecular_functionprotein domain specific binding
F0021904biological_processdorsal/ventral neural tube patterning
F0030007biological_processintracellular potassium ion homeostasis
F0030145molecular_functionmanganese ion binding
F0031410cellular_componentcytoplasmic vesicle
F0031514cellular_componentmotile cilium
F0031594cellular_componentneuromuscular junction
F0031625molecular_functionubiquitin protein ligase binding
F0032024biological_processpositive regulation of insulin secretion
F0034237molecular_functionprotein kinase A regulatory subunit binding
F0034605biological_processcellular response to heat
F0036126cellular_componentsperm flagellum
F0042995cellular_componentcell projection
F0044853cellular_componentplasma membrane raft
F0045542biological_processpositive regulation of cholesterol biosynthetic process
F0045667biological_processregulation of osteoblast differentiation
F0045722biological_processpositive regulation of gluconeogenesis
F0045879biological_processnegative regulation of smoothened signaling pathway
F0046827biological_processpositive regulation of protein export from nucleus
F0048240biological_processsperm capacitation
F0048471cellular_componentperinuclear region of cytoplasm
F0050766biological_processpositive regulation of phagocytosis
F0050804biological_processmodulation of chemical synaptic transmission
F0051726biological_processregulation of cell cycle
F0061136biological_processregulation of proteasomal protein catabolic process
F0070417biological_processcellular response to cold
F0070613biological_processregulation of protein processing
F0071333biological_processcellular response to glucose stimulus
F0071374biological_processcellular response to parathyroid hormone stimulus
F0071377biological_processcellular response to glucagon stimulus
F0097546cellular_componentciliary base
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F0099170biological_processpostsynaptic modulation of chemical synaptic transmission
F0106310molecular_functionprotein serine kinase activity
F0141156biological_processcAMP/PKA signal transduction
F1904262biological_processnegative regulation of TORC1 signaling
F1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
F1990044biological_processprotein localization to lipid droplet
F2000810biological_processregulation of bicellular tight junction assembly
H0000122biological_processnegative regulation of transcription by RNA polymerase II
H0000166molecular_functionnucleotide binding
H0000287molecular_functionmagnesium ion binding
H0001669cellular_componentacrosomal vesicle
H0001707biological_processmesoderm formation
H0001843biological_processneural tube closure
H0004672molecular_functionprotein kinase activity
H0004674molecular_functionprotein serine/threonine kinase activity
H0004691molecular_functioncAMP-dependent protein kinase activity
H0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005813cellular_componentcentrosome
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0005929cellular_componentcilium
H0005930cellular_componentaxoneme
H0005952cellular_componentcAMP-dependent protein kinase complex
H0006397biological_processmRNA processing
H0006468biological_processprotein phosphorylation
H0006611biological_processprotein export from nucleus
H0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
H0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
H0016020cellular_componentmembrane
H0016301molecular_functionkinase activity
H0016607cellular_componentnuclear speck
H0016740molecular_functiontransferase activity
H0018105biological_processpeptidyl-serine phosphorylation
H0019901molecular_functionprotein kinase binding
H0019904molecular_functionprotein domain specific binding
H0021904biological_processdorsal/ventral neural tube patterning
H0030007biological_processintracellular potassium ion homeostasis
H0030145molecular_functionmanganese ion binding
H0031410cellular_componentcytoplasmic vesicle
H0031514cellular_componentmotile cilium
H0031594cellular_componentneuromuscular junction
H0031625molecular_functionubiquitin protein ligase binding
H0032024biological_processpositive regulation of insulin secretion
H0034237molecular_functionprotein kinase A regulatory subunit binding
H0034605biological_processcellular response to heat
H0036126cellular_componentsperm flagellum
H0042995cellular_componentcell projection
H0044853cellular_componentplasma membrane raft
H0045542biological_processpositive regulation of cholesterol biosynthetic process
H0045667biological_processregulation of osteoblast differentiation
H0045722biological_processpositive regulation of gluconeogenesis
H0045879biological_processnegative regulation of smoothened signaling pathway
H0046827biological_processpositive regulation of protein export from nucleus
H0048240biological_processsperm capacitation
H0048471cellular_componentperinuclear region of cytoplasm
H0050766biological_processpositive regulation of phagocytosis
H0050804biological_processmodulation of chemical synaptic transmission
H0051726biological_processregulation of cell cycle
H0061136biological_processregulation of proteasomal protein catabolic process
H0070417biological_processcellular response to cold
H0070613biological_processregulation of protein processing
H0071333biological_processcellular response to glucose stimulus
H0071374biological_processcellular response to parathyroid hormone stimulus
H0071377biological_processcellular response to glucagon stimulus
H0097546cellular_componentciliary base
H0098794cellular_componentpostsynapse
H0098978cellular_componentglutamatergic synapse
H0099170biological_processpostsynaptic modulation of chemical synaptic transmission
H0106310molecular_functionprotein serine kinase activity
H0141156biological_processcAMP/PKA signal transduction
H1904262biological_processnegative regulation of TORC1 signaling
H1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
H1990044biological_processprotein localization to lipid droplet
H2000810biological_processregulation of bicellular tight junction assembly
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhkesgnh..........YAMK
ChainResidueDetails
CLEU49-LYS72

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI
ChainResidueDetails
CLEU162-ILE174

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
CASP166
DASP166
FASP166
HASP166

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING:
ChainResidueDetails
CLEU49
FLYS72
FGLU121
FLYS168
HLEU49
HLYS72
HGLU121
HLYS168
CLYS72
CGLU121
CLYS168
DLEU49
DLYS72
DGLU121
DLYS168
FLEU49

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P17612
ChainResidueDetails
CTHR48
CTHR195
DTHR48
DTHR195
FTHR48
FTHR195
HTHR48
HTHR195

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:22323819, ECO:0000305|PubMed:8395513
ChainResidueDetails
CSEP139
DSEP139
FSEP139
HSEP139

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:22323819, ECO:0000269|PubMed:8395513, ECO:0000269|PubMed:9707564
ChainResidueDetails
CTPO197
DTPO197
FTPO197
HTPO197

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21866565
ChainResidueDetails
CTYR330
DTYR330
FTYR330
HTYR330

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:8395513
ChainResidueDetails
CSEP338
DSEP338
FSEP338
HSEP338

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PDB entries from 2025-06-11

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