8UK3
The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2+ (class 6 reconstruction)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 1 | 0019028 | cellular_component | viral capsid |
| 1 | 0019058 | biological_process | viral life cycle |
| 1 | 0019062 | biological_process | virion attachment to host cell |
| 1 | 0020002 | cellular_component | host cell plasma membrane |
| 1 | 0039624 | cellular_component | viral outer capsid |
| 1 | 0039665 | biological_process | permeabilization of host organelle membrane involved in viral entry into host cell |
| 1 | 0044163 | cellular_component | host cytoskeleton |
| 1 | 0044168 | cellular_component | host cell rough endoplasmic reticulum |
| 1 | 0044172 | cellular_component | host cell endoplasmic reticulum-Golgi intermediate compartment |
| 1 | 0044423 | cellular_component | virion component |
| 1 | 0046718 | biological_process | symbiont entry into host cell |
| 1 | 0140267 | biological_process | symbiont entry into host cell via permeabilization of host membrane |
| 2 | 0019028 | cellular_component | viral capsid |
| 2 | 0019058 | biological_process | viral life cycle |
| 2 | 0019062 | biological_process | virion attachment to host cell |
| 2 | 0020002 | cellular_component | host cell plasma membrane |
| 2 | 0039624 | cellular_component | viral outer capsid |
| 2 | 0039665 | biological_process | permeabilization of host organelle membrane involved in viral entry into host cell |
| 2 | 0044163 | cellular_component | host cytoskeleton |
| 2 | 0044168 | cellular_component | host cell rough endoplasmic reticulum |
| 2 | 0044172 | cellular_component | host cell endoplasmic reticulum-Golgi intermediate compartment |
| 2 | 0044423 | cellular_component | virion component |
| 2 | 0046718 | biological_process | symbiont entry into host cell |
| 2 | 0140267 | biological_process | symbiont entry into host cell via permeabilization of host membrane |
| 3 | 0019028 | cellular_component | viral capsid |
| 3 | 0019058 | biological_process | viral life cycle |
| 3 | 0019062 | biological_process | virion attachment to host cell |
| 3 | 0020002 | cellular_component | host cell plasma membrane |
| 3 | 0039624 | cellular_component | viral outer capsid |
| 3 | 0039665 | biological_process | permeabilization of host organelle membrane involved in viral entry into host cell |
| 3 | 0044163 | cellular_component | host cytoskeleton |
| 3 | 0044168 | cellular_component | host cell rough endoplasmic reticulum |
| 3 | 0044172 | cellular_component | host cell endoplasmic reticulum-Golgi intermediate compartment |
| 3 | 0044423 | cellular_component | virion component |
| 3 | 0046718 | biological_process | symbiont entry into host cell |
| 3 | 0140267 | biological_process | symbiont entry into host cell via permeabilization of host membrane |
| a | 0019028 | cellular_component | viral capsid |
| b | 0019028 | cellular_component | viral capsid |
| c | 0019028 | cellular_component | viral capsid |
| d | 0019028 | cellular_component | viral capsid |
| e | 0019028 | cellular_component | viral capsid |
| f | 0019028 | cellular_component | viral capsid |
| g | 0019028 | cellular_component | viral capsid |
| h | 0019028 | cellular_component | viral capsid |
| i | 0019028 | cellular_component | viral capsid |
| j | 0019028 | cellular_component | viral capsid |
| k | 0019028 | cellular_component | viral capsid |
| l | 0019028 | cellular_component | viral capsid |
| m | 0019028 | cellular_component | viral capsid |
| n | 0019028 | cellular_component | viral capsid |
| o | 0019028 | cellular_component | viral capsid |
| p | 0019028 | cellular_component | viral capsid |
| q | 0019028 | cellular_component | viral capsid |
| r | 0019028 | cellular_component | viral capsid |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 693 |
| Details | Region: {"description":"Spike body and stalk (antigen domain)","evidences":[{"source":"HAMAP-Rule","id":"MF_04132","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21157433","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Region: {"description":"Hydrophobic; possible role in virus entry into host cell","evidences":[{"source":"HAMAP-Rule","id":"MF_04132","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20375171","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 81 |
| Details | Coiled coil: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04132","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21157433","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Motif: {"description":"DGE motif; interaction with ITGA2/ITGB1 heterodimer","evidences":[{"source":"HAMAP-Rule","id":"MF_04132","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11112480","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Motif: {"description":"YGL motif; interaction with ITGA4","evidences":[{"source":"HAMAP-Rule","id":"MF_04132","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16298987","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 36 |
| Details | Region: {"description":"CNP motif; interaction with ITGAV/ITGB3","evidences":[{"source":"HAMAP-Rule","id":"MF_04131","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15452204","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 36 |
| Details | Region: {"description":"LVD motif; interaction with ITGA4/ITGB1 heterodimer","evidences":[{"source":"HAMAP-Rule","id":"MF_04131","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 36 |
| Details | Region: {"description":"GPR motif; interaction with ITGAX/ITGB2","evidences":[{"source":"HAMAP-Rule","id":"MF_04131","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 108 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04131","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19520960","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 54 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04131","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19487668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19520960","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 18 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"PubMed","id":"19487668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21157433","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
